User:Pallasbr

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	HUMAN:TWST1	2013-03-28 19:17:50 CDT	GO:2000144 positive regulation of DNA-dependent transcription, initiation (P)	PMID:17332325	ECO:0000314 direct assay evidence used in manual assertion	According to Figure 3A, the TWIST protein binds to and transactivates the AKT2 promoter, leading to doasage-dependent increase in AKT2.	challenge
updatedbyinstructor	MOUSE:FOSL2	2013-04-10 20:59:41 CDT	GO:0045893 positive regulation of transcription, DNA-dependent (P)	PMID:22585681	ECO:0000314 direct assay evidence used in manual assertion	Figure 2A, shows that over a 36 hour period, FRA-2 causes greater than a 10 fold increase in ICOS mRNA levels, within mouse splenic CD4+ T cells.	challenge
updatedbyinstructor	HUMAN:E2F1	2013-04-10 22:23:29 CDT	GO:0045893 positive regulation of transcription, DNA-dependent (P)	PMID:22476863	ECO:0000314 direct assay evidence used in manual assertion	Figure 2E, shows that following UV irradiation, E2F1 up-regulates the transcription of the p19 gene in the cell.	challenge
acceptable	HUMAN:FOSL1	2013-04-11 21:00:19 CDT	GO:2000144 positive regulation of DNA-dependent transcription, initiation (P)	PMID:23027619	ECO:0000314 direct assay evidence used in manual assertion	Measured by luciferase activity, Figure 3C, distinctly demonstrates that FRA-1 up-regulates the transcription of IL-11 over 3 fold.	challenge
acceptable	HUMAN:JUN	2013-04-11 21:11:22 CDT	GO:2000144 positive regulation of DNA-dependent transcription, initiation (P)	PMID:23027619	ECO:0000314 direct assay evidence used in manual assertion	Measured through luciferase activity, Figure 3C clearly shows that transfection of c-Jun leads to nearly a 3 fold increase in the transcription of IL-11.	challenge
requireschanges	HUMAN:AKT2	2013-04-13 09:23:58 CDT	GO:2000144 positive regulation of DNA-dependent transcription, initiation (P)	PMID:21297943	ECO:0000314 direct assay evidence used in manual assertion	Figure 2A shows that the use of AKT2 siRNA, causes a decrease in the transcriptional levels of Cdk2, while scrambled or uninhibited AKT2 allows for transcriptional up-regulation of Ckd2.	challenge

acceptable:3
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Pallasbr

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Casano11, Team Its in my Jeans	HHV11:AN	GO:0004518 - nuclease activity (F)	PMID:15994834	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4
requireschanges	Finchcha, Team We Love Nickelback	PSEAE:Q9HTL4	GO:0001071 - nucleic acid binding transcription factor activity (F)	PMID:22275523	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Finchcha, Team We Love Nickelback	EMEND:E7EDM2	GO:0072659 - protein localization to plasma membrane (P)	PMID:22489878	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3

0 annotations fixed by Pallasbr

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