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MOUSE:FOSL2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Fosl2 (synonyms: Fra-2, Fra2)
Protein Name(s) Fos-related antigen 2

FRA-2

External Links
UniProt P47930
EMBL X83971
X83970
AK089371
AK145822
BC065131
CCDS CCDS19190.1
PIR I48351
RefSeq NP_032063.2
UniGene Mm.24684
ProteinModelPortal P47930
SMR P47930
STRING 10090.ENSMUSP00000031017
PhosphoSite P47930
MaxQB P47930
PRIDE P47930
Ensembl ENSMUST00000031017
GeneID 14284
KEGG mmu:14284
UCSC uc008wzi.2
uc008wzj.1
CTD 2355
MGI MGI:102858
eggNOG NOG301361
GeneTree ENSGT00730000110541
HOGENOM HOG000234334
HOVERGEN HBG005743
InParanoid P47930
KO K09030
OMA PYSRSHP
OrthoDB EOG761BVN
TreeFam TF326301
NextBio 285669
PRO PR:P47930
Proteomes UP000000589
Bgee P47930
CleanEx MM_FOSL2
Genevestigator P47930
GO GO:0005634
GO:0003690
GO:0000977
GO:0003700
GO:0032870
GO:0007565
GO:0048146
GO:0051591
GO:0051412
GO:0042493
GO:0009612
GO:0043278
GO:0032570
GO:0006366
InterPro IPR000837
IPR004827
IPR029814
PANTHER PTHR23351
PTHR23351:SF25
Pfam PF00170
PRINTS PR00042
SMART SM00338
PROSITE PS50217
PS00036

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045893

positive regulation of transcription, DNA-dependent

PMID:22585681[1]

ECO:0000314

P

Figure 2A, shows that over a 36 hour period, FRA-2 causes greater than a 10 fold increase in ICOS mRNA levels, within mouse splenic CD4+ T cells.

complete
CACAO 7593

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:22585681[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001297
MGI:MGI:102858
MGI:MGI:109384
MGI:MGI:1859147
MGI:MGI:1932093
MGI:MGI:95574
PANTHER:PTN001156258
RGD:1308198
RGD:2626
RGD:2627
RGD:2628
UniProtKB:P01100
UniProtKB:P18847
UniProtKB:P53539
WB:WBGene00001345

C

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109384
MGI:MGI:1859147
MGI:MGI:1932093
MGI:MGI:95574
MGI:MGI:95575
PANTHER:PTN001156258
RGD:2627
UniProtKB:P15407
UniProtKB:Q9NR55

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048146

positive regulation of fibroblast proliferation

PMID:7936655[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:25547114[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P15408

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032355

response to estradiol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006366

transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P15408

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:25547114[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000312)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:25547114[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003334

keratinocyte development

PMID:25547114[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001666

response to hypoxia

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2628

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P15408

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:19289495[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P15408

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15408
ensembl:ENSP00000264716

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15408
ensembl:ENSP00000264716

C

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15408
ensembl:ENSP00000264716

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15408
ensembl:ENSP00000264716

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000837
InterPro:IPR029814

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000837
InterPro:IPR004827

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004827

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000837
InterPro:IPR029814

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Watanabe, M et al. (2012) AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling. Eur. J. Immunol. 42 1850-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Foletta, VC et al. (1994) Cloning and characterisation of the mouse fra-2 gene. Oncogene 9 3305-11 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Wurm, S et al. (2015) Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 29 144-56 PubMed GONUTS page
  5. ↑ Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page
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