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PMID:7936655
| Citation |
Foletta, VC, Sonobe, MH, Suzuki, T, Endo, T, Iba, H and Cohen, DR (1994) Cloning and characterisation of the mouse fra-2 gene. Oncogene 9:3305-11 |
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| Abstract |
Transcription factor AP-1 is comprised of multiple protein complexes that include members of a family of genes related to the proto-oncogene c-fos. In this report, we have extended the analysis of one member of this family, fos-related antigen-2 (fra-2), by isolating and characterising genomic and cDNA clones encoding the mouse fra-2 homolog. The overall gene structure (number and positions of introns) was similar to that of both the chicken fra-2 gene and other members of the fos family, and the relative positions of putative enhancers in the 5' regulatory region were well conserved between the mouse and chicken fra-2 genes. High levels of fra-2 mRNA were detected in ovary, stomach, small and large intestine, brain, lung and heart. The mouse Fra-2 protein showed 94% and 87.5% conservation with human and chicken Fra-2, respectively, and mouse Fra-2, like the chicken homolog, induced transformation of chicken embryo fibroblasts. The characterisation of the mouse fra-2 gene provides a basis for analysis of Fra-2 function in the whole animal. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Chick Embryo; Cloning, Molecular; DNA, Complementary; DNA-Binding Proteins/genetics; Fos-Related Antigen-2; Humans; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger/metabolism; Species Specificity; Transcription Factors/genetics; Transformation, Genetic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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