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HUMAN:NEK8
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NEK8 (synonyms: JCK, NEK12A) | |
| Protein Name(s) | Serine/threonine-protein kinase Nek8
Never in mitosis A-related kinase 8 NimA-related protein kinase 8 Nima-related protein kinase 12a | |
| External Links | ||
| UniProt | Q86SG6 | |
| EMBL | AY242354 AY267371 AC010761 CH471159 BC112240 BC113705 AL833909 | |
| CCDS | CCDS32597.1 | |
| RefSeq | NP_835464.1 | |
| UniGene | Hs.448468 | |
| ProteinModelPortal | Q86SG6 | |
| SMR | Q86SG6 | |
| BioGrid | 129755 | |
| IntAct | Q86SG6 | |
| STRING | 9606.ENSP00000268766 | |
| ChEMBL | CHEMBL2417353 | |
| GuidetoPHARMACOLOGY | 2123 | |
| PhosphoSite | Q86SG6 | |
| DMDM | 34098463 | |
| PaxDb | Q86SG6 | |
| PRIDE | Q86SG6 | |
| DNASU | 284086 | |
| Ensembl | ENST00000268766 | |
| GeneID | 284086 | |
| KEGG | hsa:284086 | |
| UCSC | uc002hcp.3 | |
| CTD | 284086 | |
| GeneCards | GC17P027085 | |
| HGNC | HGNC:13387 | |
| HPA | HPA040661 HPA040679 | |
| MIM | 609799 613824 615415 | |
| neXtProt | NX_Q86SG6 | |
| Orphanet | 93591 294415 | |
| PharmGKB | PA38361 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000118997 | |
| HOGENOM | HOG000006908 | |
| HOVERGEN | HBG098799 | |
| InParanoid | Q86SG6 | |
| KO | K08857 | |
| OrthoDB | EOG7D59P5 | |
| PhylomeDB | Q86SG6 | |
| TreeFam | TF106472 | |
| SignaLink | Q86SG6 | |
| GeneWiki | NEK8 | |
| GenomeRNAi | 284086 | |
| NextBio | 94527 | |
| PRO | PR:Q86SG6 | |
| Proteomes | UP000005640 | |
| Bgee | Q86SG6 | |
| CleanEx | HS_NEK8 | |
| ExpressionAtlas | Q86SG6 | |
| Genevestigator | Q86SG6 | |
| GO | GO:0005737 GO:0005856 GO:0072372 GO:0005524 GO:0046872 GO:0004674 GO:0009887 GO:0035330 | |
| Gene3D | 2.130.10.30 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR009091 IPR000408 IPR002290 IPR008271 | |
| Pfam | PF00069 PF00415 | |
| PRINTS | PR00633 | |
| SMART | SM00220 | |
| SUPFAM | SSF50985 SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 PS50012 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005929 |
cilium |
ECO:0000315 |
C |
Figure 3 shows that mutant forms of NEK8 have defects in cillia localization. |
complete | |||||
|
part_of |
GO:0005929 |
cilium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035330 |
regulation of hippo signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009887 |
animal organ morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001221908 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009887 |
animal organ morphogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001221908 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005929 |
cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1890646 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0029970 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097546 |
ciliary base |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q91ZR4 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097543 |
ciliary inversin compartment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q91ZR4 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007507 |
heart development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q91ZR4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007368 |
determination of left/right symmetry |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q91ZR4 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005929 |
cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q91ZR4 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Otto, EA et al. (2008) NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. J. Am. Soc. Nephrol. 19 587-92 PubMed GONUTS page
- ↑ 2.0 2.1 Frank, V et al. (2013) Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression. Hum. Mol. Genet. 22 2177-85 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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