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HHV8P:MIR1

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Species (Taxon ID) Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi'ssarcoma-associated herpesvirus). (868565)
Gene Name(s) K3
Protein Name(s) E3 ubiquitin-protein ligase MIR1

IE1B protein Modulator of immune recognition 1 ORF K3

External Links
UniProt P90495
EMBL U75698
AF307516
AF307517
AF307518
AF307519
U71365
U83350
U93872
AF148805
RefSeq YP_001129360.1
PDB 1VYX
PDBsum 1VYX
ProteinModelPortal P90495
SMR P90495
IntAct P90495
MINT MINT-2824800
GeneID 4961486
UniPathway UPA00143
EvolutionaryTrace P90495
Proteomes UP000000942
GO GO:0044165
GO:0020002
GO:0016021
GO:0016874
GO:0008270
GO:0075509
GO:0039648
GO:0042787
GO:0039504
GO:0039511
GO:0039502
Gene3D 3.30.40.10
InterPro IPR011016
IPR013083
Pfam PF12906
SMART SM00744
PROSITE PS51292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016567

protein ubiquitination

PMID:11756476[1]

ECO:0000314

P

Fig 4 Ubiquitination of human B7.2 molecules and MHC-I molecules

complete

GO:0039648

modulation by virus of host protein ubiquitination

PMID:23460925[2]

ECO:0000315

P

As demonstrated in Figure 7, DC-SIGN and DC-SIGNR are ubiquitylated when in the presence of K3 with an intact RING-CH domain.

complete
CACAO 6892

GO:0039504

suppression by virus of host adaptive immune response

PMID:23460925[2]

ECO:0000315

P

See Figure 2. In the presence of wild-type K3, surface levels of MHC I were reduced about 80–90%. Figure 2 shows us that the levels of MHC 1 was greatly reduced with the addition of K3 and RING-CH mutated viral protein.

complete
CACAO 7033

GO:0075509

viral entry into host cell via endocytosis

PMID:23460925[2]

ECO:0000315

P

Figure 4 demonstrates that Wild-Type K3 causes a decreased amount of endocytosis of DC-SIGNR, yet enhanced endocytosis of DC-SIGN.

complete
CACAO 7044

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:23460925[2]

ECO:0000314

direct assay evidence used in manual assertion

P

See Figure 7. DC-SIGN and DC-SIGNR are ubiquitylated and degraded in a proteasomal- and lysosomal-dependent pathway by K3. It was confirmed that DC-SIGN displayed ubiquitylation only in the presence of K3 with an intact RING-CH domain.

complete
CACAO 7051

involved_in

GO:0075509

endocytosis involved in viral entry into host cell

PMID:23460925[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:23460925[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0039648

modulation by virus of host protein ubiquitination

PMID:23460925[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0039504

suppression by virus of host adaptive immune response

PMID:23460925[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011016

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1032
UniProtKB-SubCell:SL-0375

C

Seeded From UniProt

complete

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1114

P

Seeded From UniProt

complete

part_of

GO:0033644

host cell membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0039511

suppression by virus of host interferon receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1091

P

Seeded From UniProt

complete

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0899

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0044165

host cell endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1038
UniProtKB-SubCell:SL-0388

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Coscoy, L et al. (2001) A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J. Cell Biol. 155 1265-73 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Lang, SM et al. (2013) Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR. PLoS ONE 8 e58056 PubMed GONUTS page