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Category:Team Science Dance

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableMOUSE:TRPS1Kgreene, Team Science Dance2013-02-10 17:08:57 CSTGO:0001942 hair follicle development (P)PMID:23133399ECO:0000315 mutant phenotype evidence used in manual assertion

Figures 1-3: show decreased hair follicle growth in mice with mutant TRPS1.

challenge
acceptableMOUSE:HAX1Kgreene, Team Science Dance2013-02-08 22:12:15 CSTGO:0016529 sarcoplasmic reticulum (C)PMID:19920172ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows the effects of cardiac-specific HAX-1 overexpressing in mice.

challenge
unacceptableHUMAN:TBPRgruettner, Team Science Dance2013-02-08 22:10:04 CSTGO:0008134 transcription factor binding (F)PMID:22810624ECO:0000314 direct assay evidence used in manual assertion

Figure 6B shows the interaction of TFIID with DNA molecules correlated with transcription.

challenge
acceptableRAT:HAX1Kgreene, Team Science Dance2013-02-08 22:08:25 CSTGO:0016529 sarcoplasmic reticulum (C)PMID:19920172ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows HAX-1 overexpression or downregulation effects on on rat cardiomyocyte contractile function.

challenge
acceptableHUMAN:NEK8Kgreene, Team Science Dance2013-02-08 21:46:03 CSTGO:0005929 cilium (C)PMID:18199800ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3 shows that mutant forms of NEK8 have defects in cillia localization.

challenge
unacceptableHUMAN:P53Rgruettner, Team Science Dance2013-02-08 21:07:37 CSTGO:0002347 response to tumor cell (P)PMID:23300534ECO:0000314 direct assay evidence used in manual assertion

Figure 4A and Figure 4D show accumulation of p53 in OVCAR-3 cells as it inhibits proinflammatory chemokine expression in these ovarian cancer cells.

challenge
unacceptableHUMAN:P53Rgruettner, Team Science Dance2013-02-08 20:51:56 CSTGO:0002347 response to tumor cell (P)PMID:23359208ECO:0000314 direct assay evidence used in manual assertion

Figure 4B western blot shows increased p53 expression present in LNCaP cells.

challenge
unacceptableMOUSE:SOX5Kgreene, Team Science Dance2013-02-08 20:51:20 CSTGO:0060425 lung morphogenesis (P)PMID:21330457ECO:0000315 mutant phenotype evidence used in manual assertion

Table 2 shows p-values of less than 0.01 of associated genotyped SNPs with COPD

challenge
updatedbyinstructorMOUSE:KLF4Rgruettner, Team Science Dance2013-02-08 20:18:12 CSTGO:0006351 transcription, DNA-dependent (P)PMID:23372771ECO:0000315 mutant phenotype evidence used in manual assertion

As Figure 7A and 7B display, KLF4 is involved in regulation of cell differentiation.

challenge
acceptableMOUSE:TRPS1Kgreene, Team Science Dance2013-02-08 17:19:41 CSTGO:0045892 negative regulation of transcription, DNA-dependent (P)PMID:23133399ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3: qRT-PCR show increased SOX9 expression in the vibrissae follicles in mice with mutant TRPS1.

challenge


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Pages in category "Team Science Dance"

The following 2 pages are in this category, out of 2 total.


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