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MOUSE:HAX1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Hax1 (synonyms: Hs1bp1) | |
| Protein Name(s) | HCLS1-associated protein X-1
HS1-associating protein X-1 HAX-1 HS1-binding protein 1 HSP1BP-1 | |
| External Links | ||
| UniProt | O35387 | |
| EMBL | AF023482 AK002256 AK010633 AK088746 BC006688 BC098225 | |
| CCDS | CCDS17519.1 | |
| RefSeq | NP_035956.1 | |
| UniGene | Mm.256035 | |
| ProteinModelPortal | O35387 | |
| DIP | DIP-49445N | |
| IntAct | O35387 | |
| MINT | MINT-1592061 | |
| STRING | 10090.ENSMUSP00000078661 | |
| PhosphoSite | O35387 | |
| MaxQB | O35387 | |
| PaxDb | O35387 | |
| PRIDE | O35387 | |
| Ensembl | ENSMUST00000079724 | |
| GeneID | 23897 | |
| KEGG | mmu:23897 | |
| UCSC | uc008qaj.1 | |
| CTD | 10456 | |
| MGI | MGI:1346319 | |
| eggNOG | NOG45051 | |
| GeneTree | ENSGT00390000018324 | |
| HOGENOM | HOG000090247 | |
| HOVERGEN | HBG002991 | |
| InParanoid | O35387 | |
| KO | K16220 | |
| OMA | PKPAPDW | |
| OrthoDB | EOG7HTHJ5 | |
| PhylomeDB | O35387 | |
| TreeFam | TF328619 | |
| NextBio | 303661 | |
| PRO | PR:O35387 | |
| Proteomes | UP000000589 | |
| Bgee | O35387 | |
| CleanEx | MM_HAX1 | |
| ExpressionAtlas | O35387 | |
| Genevestigator | O35387 | |
| GO | GO:0015629 GO:0016324 GO:0030136 GO:0005737 GO:0005783 GO:0030027 GO:0005739 GO:0031965 GO:0016529 GO:0005667 GO:0007166 GO:0071345 GO:2000251 GO:0030854 GO:0033138 GO:0050731 GO:0014068 GO:0051897 GO:0045944 GO:0030833 | |
| InterPro | IPR017248 | |
| PIRSF | PIRSF037634 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016529 |
sarcoplasmic reticulum |
ECO:0000314 |
C |
Figure 2 shows the effects of cardiac-specific HAX-1 overexpressing in mice. |
complete | |||||
|
part_of |
GO:0016529 |
sarcoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000251 |
positive regulation of actin cytoskeleton reorganization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:727960 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030854 |
positive regulation of granulocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030833 |
regulation of actin filament polymerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030136 |
clathrin-coated vesicle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:727960 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019966 |
interleukin-1 binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:727960 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016529 |
sarcoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:727960 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:727960 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)|part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000251 |
positive regulation of actin cytoskeleton reorganization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030854 |
positive regulation of granulocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030833 |
regulation of actin filament polymerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019966 |
interleukin-1 binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O00165 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0S2Z591 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016529 |
sarcoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000932 |
P-body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhao, W et al. (2009) The anti-apoptotic protein HAX-1 is a regulator of cardiac function. Proc. Natl. Acad. Sci. U.S.A. 106 20776-81 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gallagher, AR et al. (2000) The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proc. Natl. Acad. Sci. U.S.A. 97 4017-22 PubMed GONUTS page
- ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
- ↑ 4.0 4.1 Suzuki, Y et al. (1997) HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. J. Immunol. 158 2736-44 PubMed GONUTS page
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- GO:0000932 ! P-body
- GO:0005886 ! plasma membrane
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0030854 ! positive regulation of granulocyte differentiation
- GO:0019904 ! protein domain specific binding
