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MOUSE:SOX5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Sox5 (synonyms: Sox-5) | |
| Protein Name(s) | Transcription factor SOX-5 | |
| External Links | ||
| UniProt | P35710 | |
| EMBL | X65657 X65658 AB006330 AJ010604 | |
| CCDS | CCDS39702.1 CCDS57469.1 | |
| PIR | S25195 | |
| RefSeq | NP_001230092.1 | |
| UniGene | Mm.1752 | |
| PDB | 1I11 | |
| PDBsum | 1I11 | |
| ProteinModelPortal | P35710 | |
| SMR | P35710 | |
| BioGrid | 203409 | |
| IntAct | P35710 | |
| ChEMBL | CHEMBL2176780 | |
| PhosphoSite | P35710 | |
| MaxQB | P35710 | |
| PRIDE | P35710 | |
| Ensembl | ENSMUST00000111748 | |
| GeneID | 20678 | |
| KEGG | mmu:20678 | |
| CTD | 6660 | |
| MGI | MGI:98367 | |
| eggNOG | NOG253815 | |
| HOGENOM | HOG000056455 | |
| HOVERGEN | HBG003915 | |
| InParanoid | P35710 | |
| KO | K09269 | |
| PhylomeDB | P35710 | |
| EvolutionaryTrace | P35710 | |
| NextBio | 299173 | |
| PRO | PR:P35710 | |
| Proteomes | UP000000589 | |
| Bgee | P35710 | |
| CleanEx | MM_SOX5 | |
| ExpressionAtlas | P35710 | |
| Genevestigator | P35710 | |
| GO | GO:0044798 GO:0005634 GO:0003677 GO:0046982 GO:0000981 GO:0003700 GO:0044212 GO:0051216 GO:0045165 GO:0021953 GO:0001701 GO:0045892 GO:0048709 GO:0032332 GO:0045944 GO:0060164 GO:0006366 | |
| Gene3D | 1.10.30.10 | |
| InterPro | IPR009071 | |
| Pfam | PF00505 | |
| SMART | SM00398 | |
| SUPFAM | SSF47095 | |
| PROSITE | PS50118 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0060425 |
lung morphogenesis |
ECO:0000315 |
P |
Table 2 shows p-values of less than 0.01 of associated genotyped SNPs with COPD |
complete | |||||
|
involved_in |
GO:0032332 |
positive regulation of chondrocyte differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98367 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98367 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98367 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032332 |
positive regulation of chondrocyte differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98367 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000741 |
positive regulation of mesenchymal stem cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0061036 |
positive regulation of cartilage development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060164 |
regulation of timing of neuron differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_results_in_acquisition_of_features_of:(CL:0000540) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0055059 |
asymmetric neuroblast division |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051216 |
cartilage development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98368 |
P |
results_in_development_of:(EMAPA:17679) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048709 |
oligodendrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2447147 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045165 |
cell fate commitment |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98368 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044798 |
nuclear transcription factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032332 |
positive regulation of chondrocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0021953 |
central nervous system neuron differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929913 |
P |
results_in_acquisition_of_features_of:(CL:0000540) |
Seeded From UniProt |
complete | |
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98368 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001701 |
in utero embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2447147 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98368 |
P |
has_regulation_target:(MGI:MGI:88452) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000138) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_participant:(MGI:MGI:88452) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hersh, CP et al. (2011) SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. Am. J. Respir. Crit. Care Med. 183 1482-9 PubMed GONUTS page
- ↑ Takigawa, Y et al. (2010) The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. J. Cell. Sci. 123 3780-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Lai, T et al. (2008) SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron 57 232-47 PubMed GONUTS page
- ↑ 5.0 5.1 Brent, AE et al. (2005) Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132 515-28 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Stolt, CC et al. (2006) SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev. Cell 11 697-709 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Ng, CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 40 4933-41 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Lefebvre, V et al. (1998) A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 17 5718-33 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Kiselak, EA et al. (2010) Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5. J. Biol. Chem. 285 30496-505 PubMed GONUTS page
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- GO:0032332 ! positive regulation of chondrocyte differentiation
- GO:0061036 ! positive regulation of cartilage development
- GO:2000741 ! positive regulation of mesenchymal stem cell differentiation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0046982 ! protein heterodimerization activity
