GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17084361

From GONUTS
Jump to: navigation, search
Citation

Stolt, CC, Schlierf, A, Lommes, P, Hillgärtner, S, Werner, T, Kosian, T, Sock, E, Kessaris, N, Richardson, WD, Lefebvre, V and Wegner, M (2006) SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev. Cell 11:697-709

Abstract

The myelin-forming oligodendrocytes are an excellent model to study transcriptional regulation of specification events, lineage progression, and terminal differentiation in the central nervous system. Here, we show that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord. They repress specification and terminal differentiation and influence migration patterns. As a consequence, oligodendrocyte precursors and terminally differentiating oligodendrocytes appear precociously in spinal cords deficient for both Sox proteins. Sox5 and Sox6 have opposite functions than the group E Sox proteins Sox9 and Sox10, which promote oligodendrocyte specification and terminal differentiation. Both genetic as well as molecular evidence suggests that Sox5 and Sox6 directly interfere with the function of group E Sox proteins. Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development.

Links

PubMed Online version:10.1016/j.devcel.2006.08.011

Keywords

Animals; Cell Differentiation; Cell Lineage; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Gene Expression Regulation, Developmental; High Mobility Group Proteins/genetics; High Mobility Group Proteins/physiology; Mice; Mice, Knockout; Mutation; Myelin Sheath/metabolism; Nuclear Proteins/genetics; Nuclear Proteins/physiology; Oligodendroglia/cytology; Oligodendroglia/physiology; SOX9 Transcription Factor; SOXD Transcription Factors; SOXE Transcription Factors; Spinal Cord/cytology; Spinal Cord/embryology; Spinal Cord/metabolism; Transcription Factors/genetics; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SOX5

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P40645

F

Seeded From UniProt

complete

MOUSE:SOX5

enables

GO:0000976: transcription cis-regulatory region binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX6

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P35710

F

Seeded From UniProt

complete

MOUSE:SOX6

acts_upstream_of_or_within

GO:0021778: oligodendrocyte cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2447148

P

Seeded From UniProt

complete

MOUSE:SOX6

acts_upstream_of_or_within

GO:0001701: in utero embryonic development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2447148

P

Seeded From UniProt

complete

MOUSE:SOX6

enables

GO:0000976: transcription cis-regulatory region binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX6

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX6

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2447148

P

Seeded From UniProt

complete

MOUSE:SOX6

acts_upstream_of_or_within

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SOX6

acts_upstream_of_or_within

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SOX8

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2154329

F

Seeded From UniProt

complete

MOUSE:SOX8

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2154329

P

Seeded From UniProt

complete

MOUSE:SOX8

acts_upstream_of_or_within

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2154329

P

Seeded From UniProt

complete

MOUSE:SOX9

enables

GO:0000976: transcription cis-regulatory region binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX9

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2429649

F

Seeded From UniProt

complete

MOUSE:SOX9

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2429649

P

Seeded From UniProt

complete

MOUSE:SOX9

acts_upstream_of_or_within

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2429649

P

Seeded From UniProt

complete

MOUSE:SOX10

enables

GO:0000976: transcription cis-regulatory region binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX10

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2151173

F

Seeded From UniProt

complete

MOUSE:SOX10

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2151173

P

Seeded From UniProt

complete

MOUSE:SOX10

acts_upstream_of_or_within

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2151173

P

Seeded From UniProt

complete

MOUSE:SOX5

acts_upstream_of_or_within

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SOX5

enables

GO:0044212: transcription regulatory region DNA binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX5

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:SOX5

acts_upstream_of_or_within

GO:0001701: in utero embryonic development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2447147

P

Seeded From UniProt

complete

MOUSE:SOX5

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2447147

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.