HUMAN:TBP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TBP (synonyms: GTF2D1, TF2D, TFIID)
Protein Name(s)	TATA-box-binding protein TATA sequence-binding protein TATA-binding factor TATA-box factor Transcription initiation factor TFIID TBP subunit
External Links
UniProt	P20226
EMBL	X54993 M55654 M34960 AK304648 CR456776 AL031259
CCDS	CCDS5315.1 CCDS55077.1
PIR	A34830
RefSeq	NP_001165556.1 NP_003185.1
UniGene	Hs.590872
PDB	1C9B 1CDW 1JFI 1NVP 1TGH
PDBsum	1C9B 1CDW 1JFI 1NVP 1TGH
ProteinModelPortal	P20226
SMR	P20226
BioGrid	112771
DIP	DIP-1078N
IntAct	P20226
MINT	MINT-156456
STRING	9606.ENSP00000230354
PhosphoSite	P20226
DMDM	1351223
MaxQB	P20226
PaxDb	P20226
PRIDE	P20226
DNASU	6908
Ensembl	ENST00000230354 ENST00000392092 ENST00000540980
GeneID	6908
KEGG	hsa:6908
UCSC	uc003qxt.3
CTD	6908
GeneCards	GC06P170863
GeneReviews	TBP
HGNC	HGNC:11588
HPA	CAB009442
MIM	600075 607136
neXtProt	NX_P20226
Orphanet	98759
PharmGKB	PA36352
eggNOG	COG2101
GeneTree	ENSGT00410000025389
HOGENOM	HOG000105164
HOVERGEN	HBG044997
InParanoid	P20226
KO	K03120
OMA	PLFSPMM
PhylomeDB	P20226
TreeFam	TF300102
Reactome	REACT_1036 REACT_1074 REACT_1655 REACT_1851 REACT_1913 REACT_200827 REACT_200856 REACT_2089 REACT_2204 REACT_22107 REACT_22339 REACT_347 REACT_571 REACT_6233 REACT_6253 REACT_6332 REACT_834 REACT_953
SignaLink	P20226
EvolutionaryTrace	P20226
GeneWiki	TATA-binding_protein
GenomeRNAi	6908
NextBio	27015
PRO	PR:P20226
Proteomes	UP000005640
Bgee	P20226
CleanEx	HS_TBP
ExpressionAtlas	P20226
Genevestigator	P20226
GO	GO:0005737 GO:0001939 GO:0001940 GO:0005719 GO:0005654 GO:0005672 GO:0005669 GO:0070491 GO:0003700 GO:0008134 GO:0044212 GO:0010467 GO:0045893 GO:0007283 GO:0006363 GO:0006362 GO:0006368 GO:0006360 GO:0006366 GO:0006383 GO:0006361 GO:0006367 GO:0016032
Gene3D	1.25.10.10 3.30.310.10
HAMAP	MF_00408
InterPro	IPR011989 IPR012295 IPR000814
PANTHER	PTHR10126
Pfam	PF00352
PRINTS	PR00686
PROSITE	PS00351

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P29037	F		Seeded From UniProt	complete
enables	GO:0016251	RNA polymerase II general transcription initiation factor activity	PMID:27193682^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:16263792^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15641800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017162	aryl hydrocarbon receptor binding	PMID:15641800^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35869	F		Seeded From UniProt	complete
enables	GO:0001093	TFIIB-class transcription factor binding	PMID:9841876^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00403	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:27193682^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:27193682^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:27007846^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27007846^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000995	RNA polymerase III general transcription initiation factor activity	PMID:26638071^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006383	transcription by RNA polymerase III	PMID:26638071^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:24289924^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000124762) coincident_with:(SO:0001668) exists_during:(GO:0034644)	Seeded From UniProt	complete
part_of	GO:0097550	transcriptional preinitiation complex	PMID:9841876^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001047	core promoter binding	PMID:9841876^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:25336585^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UL18	F		Seeded From UniProt	complete
	GO:0008134	transcription factor binding	PMID:22810624^[9]	ECO:0000314			F		Figure 6B shows the interaction of TFIID with DNA molecules correlated with transcription.	complete CACAO 6418
enables	GO:0019899	enzyme binding	PMID:25336585^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UKV8	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9841876^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	PMID:9841876^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016251	RNA polymerase II general transcription initiation factor activity	PMID:9841876^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:18838386^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9ULM3	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:8626665^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P52657	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:7724559^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P52655	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:7724559^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P52657	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:7724559^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:19861239^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005672	transcription factor TFIIA complex	PMID:7724559^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:7933101^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16540471^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11005381^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12676957^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05412	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:9722567^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12947	F		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:7729427^[19]	ECO:0000305	curator inference used in manual assertion	GO:0005669	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:7729427^[19]	ECO:0000305	curator inference used in manual assertion	GO:0005669	P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:7729427^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070898	RNA polymerase III preinitiation complex assembly	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000013138 SGD:S000000950	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003687 FB:FBgn0010287 PANTHER:PTN000013136 UniProtKB:P20226 WB:WBGene00006542	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003687 FB:FBgn0261793 MGI:MGI:101838 PANTHER:PTN000013136 UniProtKB:P20226 UniProtKB:P52653 UniProtKB:Q8I440 ZFIN:ZDB-GENE-030616-563 ZFIN:ZDB-GENE-040520-2	P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003687 PANTHER:PTN000013137 PomBase:SPAC29E6.08 RGD:67398 SGD:S000000950 UniProtKB:P20226 UniProtKB:Q8I440	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000189736 FB:FBgn0010287 FB:FBgn0261793 PANTHER:PTN000013136	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261793 MGI:MGI:2684058 PANTHER:PTN000013136 RGD:67398 WB:WBGene00006542	F		Seeded From UniProt	complete
enables	GO:0001016	RNA polymerase III regulatory region DNA binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000013138 SGD:S000000950	F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261793 PANTHER:PTN000013136 PomBase:SPAC29E6.08 SGD:S000000950	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003687 FB:FBgn0010287 MGI:MGI:101838 PANTHER:PTN000013136 UniProtKB:P62380	F		Seeded From UniProt	complete
part_of	GO:0000126	transcription factor TFIIIB complex	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003687 PANTHER:PTN000013138 SGD:S000000950 dictyBase:DDB_G0275617	C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:9027316^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006383	transcription by RNA polymerase III	PMID:9027316^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:14580349^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000981	P		Seeded From UniProt	complete
part_of	GO:0045120	pronucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	C		Seeded From UniProt	complete
involved_in	GO:0006383	transcription by RNA polymerase III	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	F		Seeded From UniProt	complete
part_of	GO:0001940	male pronucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	C		Seeded From UniProt	complete
part_of	GO:0001939	female pronucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	C		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29037 ensembl:ENSMUSP00000124317	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q66HB1 ensembl:ENSRNOP00000002038	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q66HB1 ensembl:ENSRNOP00000002038	P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q66HB1 ensembl:ENSRNOP00000002038	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q66HB1 ensembl:ENSRNOP00000002038	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q66HB1 ensembl:ENSRNOP00000002038	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q66HB1 ensembl:ENSRNOP00000002038	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000814 InterPro:IPR033710	F		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000814 InterPro:IPR033710	P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:2363050^[23] Reactome:R-HSA-75953 Reactome:R-HSA-73779	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:2363050^[23] PMID:2194289^[24] Reactome:R-HSA-73857	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:2363050^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045815	positive regulation of gene expression, epigenetic	Reactome:R-HSA-5250924	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042795	snRNA transcription by RNA polymerase II	Reactome:R-HSA-6807505	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006363	termination of RNA polymerase I transcription	Reactome:R-HSA-73863	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006362	transcription elongation from RNA polymerase I promoter	Reactome:R-HSA-73777	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006361	transcription initiation from RNA polymerase I promoter	Reactome:R-HSA-73772 Reactome:R-HSA-73762	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9613497 Reactome:R-HSA-9613494 Reactome:R-HSA-9023861 Reactome:R-HSA-9023860 Reactome:R-HSA-9009533 Reactome:R-HSA-9009526 Reactome:R-HSA-83805 Reactome:R-HSA-83803 Reactome:R-HSA-83793 Reactome:R-HSA-83790 Reactome:R-HSA-83723 Reactome:R-HSA-76056 Reactome:R-HSA-75949 Reactome:R-HSA-75873 Reactome:R-HSA-75869 Reactome:R-HSA-75866 Reactome:R-HSA-75864 Reactome:R-HSA-75862 Reactome:R-HSA-75861 Reactome:R-HSA-75856 Reactome:R-HSA-75850 Reactome:R-HSA-75095 Reactome:R-HSA-74994 Reactome:R-HSA-74993 Reactome:R-HSA-74992 Reactome:R-HSA-74986 Reactome:R-HSA-73946 Reactome:R-HSA-73769 Reactome:R-HSA-73758 Reactome:R-HSA-73739 Reactome:R-HSA-73729 Reactome:R-HSA-6814885 Reactome:R-HSA-6814559 Reactome:R-HSA-6814555 Reactome:R-HSA-6814549 Reactome:R-HSA-6810238 Reactome:R-HSA-6810235 Reactome:R-HSA-6810234 Reactome:R-HSA-6810233 Reactome:R-HSA-6805399 Reactome:R-HSA-5250947 Reactome:R-HSA-5250938 Reactome:R-HSA-5250930 Reactome:R-HSA-109639 Reactome:R-HSA-109638 Reactome:R-HSA-109637 Reactome:R-HSA-109636	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 He, Y et al. (2016) Near-atomic resolution visualization of human transcription promoter opening. Nature 533 359-65 PubMed GONUTS page
↑ Zhao, Q et al. (2006) Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood 107 2138-45 PubMed GONUTS page
↑ ^3.0 ^3.1 Watt, K et al. (2005) Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. Biochemistry 44 734-43 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Sabbah, M et al. (1998) Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB. Biochem. J. 336 ( Pt 3) 639-46 PubMed GONUTS page
↑ ^5.0 ^5.1 Louder, RK et al. (2016) Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature 531 604-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Gouge, J et al. (2015) Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell 163 1375-87 PubMed GONUTS page
↑ Wu, Y et al. (2014) Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol. Cell 53 63-74 PubMed GONUTS page
↑ ^8.0 ^8.1 Zhang, Y et al. (2014) Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs. RNA 20 1878-89 PubMed GONUTS page
↑ Revyakin, A et al. (2012) Transcription initiation by human RNA polymerase II visualized at single-molecule resolution. Genes Dev. 26 1691-702 PubMed GONUTS page
↑ Wang, YL et al. (2008) Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J. Biol. Chem. 283 33808-15 PubMed GONUTS page
↑ Ozer, J et al. (1996) Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. J. Biol. Chem. 271 11182-90 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 DeJong, J et al. (1995) Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. Proc. Natl. Acad. Sci. U.S.A. 92 3313-7 PubMed GONUTS page
↑ Kodeboyina, S et al. (2010) cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol. Dis. 44 7-15 PubMed GONUTS page
↑ Ou, SH et al. (1994) Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J. Virol. 68 7188-99 PubMed GONUTS page
↑ Imai, K & Okamoto, T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J. Biol. Chem. 281 12495-505 PubMed GONUTS page
↑ Yuan, CX & Gurley, WB (2000) Potential targets for HSF1 within the preinitiation complex. Cell Stress Chaperones 5 229-42 PubMed GONUTS page
↑ Munz, C et al. (2003) TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. J. Biol. Chem. 278 21510-6 PubMed GONUTS page
↑ Hellqvist, M et al. (1998) The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. J. Biol. Chem. 273 23335-43 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Mengus, G et al. (1995) Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. EMBO J. 14 1520-31 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 ^20.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^21.0 ^21.1 Mittal, V & Hernandez, N (1997) Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science 275 1136-40 PubMed GONUTS page
↑ Guermah, M et al. (2003) The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol. Cell 12 991-1001 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Peterson, MG et al. (1990) Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248 1625-30 PubMed GONUTS page
↑ Kao, CC et al. (1990) Cloning of a transcriptionally active human TATA binding factor. Science 248 1646-50 PubMed GONUTS page

[PMID:27193682-1] 1.0 ^1.1 ^1.2 He, Y et al. (2016) Near-atomic resolution visualization of human transcription promoter opening. Nature 533 359-65 PubMed GONUTS page

[PMID:16263792-2] Zhao, Q et al. (2006) Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood 107 2138-45 PubMed GONUTS page

[PMID:15641800-3] 3.0 ^3.1 Watt, K et al. (2005) Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. Biochemistry 44 734-43 PubMed GONUTS page

[PMID:9841876-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Sabbah, M et al. (1998) Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB. Biochem. J. 336 ( Pt 3) 639-46 PubMed GONUTS page

[PMID:27007846-5] 5.0 ^5.1 Louder, RK et al. (2016) Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature 531 604-9 PubMed GONUTS page

[PMID:26638071-6] 6.0 ^6.1 Gouge, J et al. (2015) Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell 163 1375-87 PubMed GONUTS page

[PMID:24289924-7] Wu, Y et al. (2014) Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol. Cell 53 63-74 PubMed GONUTS page

[PMID:25336585-8] 8.0 ^8.1 Zhang, Y et al. (2014) Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs. RNA 20 1878-89 PubMed GONUTS page

[PMID:22810624-9] Revyakin, A et al. (2012) Transcription initiation by human RNA polymerase II visualized at single-molecule resolution. Genes Dev. 26 1691-702 PubMed GONUTS page

[PMID:18838386-10] Wang, YL et al. (2008) Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J. Biol. Chem. 283 33808-15 PubMed GONUTS page

[PMID:8626665-11] Ozer, J et al. (1996) Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. J. Biol. Chem. 271 11182-90 PubMed GONUTS page

[PMID:7724559-12] 12.0 ^12.1 ^12.2 ^12.3 DeJong, J et al. (1995) Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. Proc. Natl. Acad. Sci. U.S.A. 92 3313-7 PubMed GONUTS page

[PMID:19861239-13] Kodeboyina, S et al. (2010) cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol. Dis. 44 7-15 PubMed GONUTS page

[PMID:7933101-14] Ou, SH et al. (1994) Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J. Virol. 68 7188-99 PubMed GONUTS page

[PMID:16540471-15] Imai, K & Okamoto, T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J. Biol. Chem. 281 12495-505 PubMed GONUTS page

[PMID:11005381-16] Yuan, CX & Gurley, WB (2000) Potential targets for HSF1 within the preinitiation complex. Cell Stress Chaperones 5 229-42 PubMed GONUTS page

[PMID:12676957-17] Munz, C et al. (2003) TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. J. Biol. Chem. 278 21510-6 PubMed GONUTS page

[PMID:9722567-18] Hellqvist, M et al. (1998) The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. J. Biol. Chem. 273 23335-43 PubMed GONUTS page

[PMID:7729427-19] 19.0 ^19.1 ^19.2 Mengus, G et al. (1995) Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. EMBO J. 14 1520-31 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 ^20.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9027316-21] 21.0 ^21.1 Mittal, V & Hernandez, N (1997) Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science 275 1136-40 PubMed GONUTS page

[PMID:14580349-22] Guermah, M et al. (2003) The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol. Cell 12 991-1001 PubMed GONUTS page

[PMID:2363050-23] 23.0 ^23.1 ^23.2 Peterson, MG et al. (1990) Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248 1625-30 PubMed GONUTS page

[PMID:2194289-24] Kao, CC et al. (1990) Cloning of a transcriptionally active human TATA binding factor. Science 248 1646-50 PubMed GONUTS page

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HUMAN:TBP

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