HHV8P:MIR2

Species (Taxon ID)	Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi'ssarcoma-associated herpesvirus). (868565)
Gene Name(s)	K5
Protein Name(s)	E3 ubiquitin-protein ligase MIR2 IE1A protein Modulator of immune recognition 2 ORF K5
External Links
UniProt	P90489
EMBL	U83349 U75698 U71366 AF117253 U93872 AF148805
RefSeq	YP_001129365.1
ProteinModelPortal	P90489
SMR	P90489
BioGrid	1776945
IntAct	P90489
MINT	MINT-2824380
GeneID	4961442
UniPathway	UPA00143
Proteomes	UP000000942
GO	GO:0044165 GO:0020002 GO:0016021 GO:0016874 GO:0008270 GO:0075509 GO:0039648 GO:0044078 GO:0042787 GO:0039504 GO:0039511 GO:0039502
Gene3D	3.30.40.10
InterPro	IPR011016 IPR013083
Pfam	PF12906
SMART	SM00744
PROSITE	PS51292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0039648	modulation by virus of host protein ubiquitination	PMID:23460925	ECO:0000315			P		As demonstrated in Figure 7, DC-SIGN and DC-SIGNR are ubiquitylated when in the presence of K5 with an intact RING-CH domain.	complete CACAO 6891
	GO:0044078	positive regulation by symbiont of host receptor-mediated endocytosis	PMID:23460925	ECO:0000315			P		As demonstrated by Figure 4C, in the presence of wildtype K5, a small but significant acceleration in endocytosis of DC-SIGN was detected	complete CACAO 6893
	GO:0039504	suppression by virus of host adaptive immune response	PMID:23460925	ECO:0000315			P		See Figure 2. In the presence of wild-type K5, surface levels of MHC I were reduced about 80–90%. Figure 2 shows us that the levels of MHC 1 was greatly reduced with the addition of K5 and RING-CH mutated viral protein.	complete CACAO 7032
	GO:0075509	viral entry into host cell via endocytosis	PMID:23460925	ECO:0000315			P		Figure 4 demonstrates that Wild-Type K5 causes a decreased amount of endocytosis of DC-SIGNR, yet enhanced endocytosis of DC-SIGN.	complete CACAO 7043
	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:23460925	ECO:0000314	direct assay evidence used in manual assertion		P		See Figure 7. DC-SIGN and DC-SIGNR are ubiquitylated and degraded in a proteasomal- and lysosomal-dependent pathway by K5. It was confirmed that DC-SIGN displayed ubiquitylation only in the presence of K5 with an intact RING-CH domain.	complete CACAO 7050
involved_in	GO:0075509	endocytosis involved in viral entry into host cell	PMID:23460925	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044078	positive regulation by symbiont of host receptor-mediated endocytosis	PMID:23460925	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:23460925	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039648	modulation by virus of host protein ubiquitination	PMID:23460925	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039504	suppression by virus of host adaptive immune response	PMID:23460925	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011016	F		Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0044165	host cell endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1038 UniProtKB-SubCell:SL-0388	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0375	C		Seeded From UniProt	complete
involved_in	GO:0039511	suppression by virus of host interferon receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1091	P		Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1114	P		Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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References

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