User:Rjackson3

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:CFTR	2013-02-09 04:21:52 CST	GO:0030324 lung development (P)	PMID:23226399	ECO:0000314 direct assay evidence used in manual assertion	Cigarette smoke can lead to the over regulation of MiR-101. MiR-101 is one of the proteins that is responsible for regulating the CFTR protein chloride channels in the lungs. The CFTR chloride channel is responsible for carrying chloride ions across the membrane. Mutations of the chloride channel can cause mucous to accumulate on the membrane which is a sign of cystic fibrosis. Figure 6 shows that MiR-101 is up regulated in is COPD patients with histories of smoking. The up regulation in COPD patients with a history of smoking showed great suppression in the CFTR protein.	challenge
updatedbyinstructor	MOUSE:FOXD1	2013-02-09 12:46:49 CST	GO:0032275 luteinizing hormone secretion (P)	PMID:23284914	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig 4	challenge

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unacceptable:1
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flagged:0

Annotations challenged by Rjackson3

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

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