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MOUSE:FOXD1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Foxd1 (synonyms: Fkhl8, Freac4, Hfhbf2) | |
Protein Name(s) | Forkhead box protein D1
Brain factor 2 BF-2 Forkhead-related protein FKHL8 Forkhead-related transcription factor 4 FREAC-4 HFH-BF-2 | |
External Links | ||
UniProt | Q61345 | |
EMBL | L38607 AK132390 AK142034 | |
CCDS | CCDS36759.1 | |
RefSeq | NP_032268.2 | |
UniGene | Mm.347441 | |
ProteinModelPortal | Q61345 | |
SMR | Q61345 | |
STRING | 10090.ENSMUSP00000100725 | |
PhosphoSite | Q61345 | |
PaxDb | Q61345 | |
PRIDE | Q61345 | |
Ensembl | ENSMUST00000105098 | |
GeneID | 15229 | |
KEGG | mmu:15229 | |
UCSC | uc009van.1 | |
CTD | 2297 | |
MGI | MGI:1347463 | |
eggNOG | COG5025 | |
GeneTree | ENSGT00760000118904 | |
HOGENOM | HOG000231285 | |
HOVERGEN | HBG051641 | |
InParanoid | Q61345 | |
KO | K09397 | |
OMA | GAYGCAY | |
OrthoDB | EOG7C8GHD | |
TreeFam | TF316127 | |
NextBio | 287823 | |
PRO | PR:Q61345 | |
Proteomes | UP000000589 | |
Bgee | Q61345 | |
CleanEx | MM_FOXD1 | |
Genevestigator | Q61345 | |
GO | GO:0005634 GO:0003677 GO:0008301 GO:0000978 GO:0001077 GO:0043565 GO:0007411 GO:0001658 GO:0060678 GO:0001822 GO:0072213 GO:0072267 GO:0072210 GO:0045892 GO:0072076 GO:0072268 GO:0030513 GO:0010628 GO:0090184 GO:0045944 | |
Gene3D | 1.10.10.10 | |
InterPro | IPR001766 IPR018122 IPR011991 | |
Pfam | PF00250 | |
PRINTS | PR00053 | |
SMART | SM00339 | |
PROSITE | PS00657 PS00658 PS50039 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0032275 |
luteinizing hormone secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:18654) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090184 |
positive regulation of kidney development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
GO:0032275 |
luteinizing hormone secretion |
ECO:0000315 |
P |
Fig 4 |
complete | |||||
involved_in |
GO:0072268 |
pattern specification involved in metanephros development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072267 |
metanephric capsule specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072213 |
metanephric capsule development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072210 |
metanephric nephron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072076 |
nephrogenic mesenchyme development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060678 |
dichotomous subdivision of terminal units involved in ureteric bud branching |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030513 |
positive regulation of BMP signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000930906 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009653 |
anatomical structure morphogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1347476 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000659 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000659 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000659 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(MGI:MGI:105095) |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(MGI:MGI:105095) |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008301 |
DNA binding, bending |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008301 |
DNA binding, bending |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007411 |
axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2180362 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001822 |
kidney development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2180362 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001658 |
branching involved in ureteric bud morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q16676 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008301 |
DNA binding, bending |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q16676 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q16676 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gumbel, JH et al. (2012) The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice. PLoS ONE 7 e52156 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Zhang, H et al. (2003) Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr. Biol. 13 1625-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Levinson, RS et al. (2005) Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 132 529-39 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Pierrou, S et al. (1994) Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13 5002-12 PubMed GONUTS page
- ↑ Herrera, E et al. (2004) Foxd1 is required for proper formation of the optic chiasm. Development 131 5727-39 PubMed GONUTS page
- ↑ Hatini, V et al. (1996) Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev. 10 1467-78 PubMed GONUTS page
d
- GO:0060678 ! dichotomous subdivision of terminal units involved in ureteric bud branching
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0001228 ! DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0003677 ! DNA binding
- GO:0008301 ! DNA binding, bending
g
m
n
p
- GO:0072268 ! pattern specification involved in metanephros development
- GO:0030513 ! positive regulation of BMP signaling pathway
- GO:0010628 ! positive regulation of gene expression
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0090184 ! positive regulation of kidney development
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