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MOUSE:FOXD1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Foxd1 (synonyms: Fkhl8, Freac4, Hfhbf2)
Protein Name(s) Forkhead box protein D1

Brain factor 2 BF-2 Forkhead-related protein FKHL8 Forkhead-related transcription factor 4 FREAC-4 HFH-BF-2

External Links
UniProt Q61345
EMBL L38607
AK132390
AK142034
CCDS CCDS36759.1
RefSeq NP_032268.2
UniGene Mm.347441
ProteinModelPortal Q61345
SMR Q61345
STRING 10090.ENSMUSP00000100725
PhosphoSite Q61345
PaxDb Q61345
PRIDE Q61345
Ensembl ENSMUST00000105098
GeneID 15229
KEGG mmu:15229
UCSC uc009van.1
CTD 2297
MGI MGI:1347463
eggNOG COG5025
GeneTree ENSGT00760000118904
HOGENOM HOG000231285
HOVERGEN HBG051641
InParanoid Q61345
KO K09397
OMA GAYGCAY
OrthoDB EOG7C8GHD
TreeFam TF316127
NextBio 287823
PRO PR:Q61345
Proteomes UP000000589
Bgee Q61345
CleanEx MM_FOXD1
Genevestigator Q61345
GO GO:0005634
GO:0003677
GO:0008301
GO:0000978
GO:0001077
GO:0043565
GO:0007411
GO:0001658
GO:0060678
GO:0001822
GO:0072213
GO:0072267
GO:0072210
GO:0045892
GO:0072076
GO:0072268
GO:0030513
GO:0010628
GO:0090184
GO:0045944
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00657
PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0032275

luteinizing hormone secretion

PMID:23284914[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:18654)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090184

positive regulation of kidney development

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0032275

luteinizing hormone secretion

PMID:23284914[1]

ECO:0000315

P

Fig 4

complete
CACAO 6427

involved_in

GO:0072268

pattern specification involved in metanephros development

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072267

metanephric capsule specification

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072213

metanephric capsule development

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072210

metanephric nephron development

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072076

nephrogenic mesenchyme development

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060678

dichotomous subdivision of terminal units involved in ureteric bud branching

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030513

positive regulation of BMP signaling pathway

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:15634693[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000930906
WB:WBGene00004013

P

Seeded From UniProt

complete

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347476
PANTHER:PTN000930906

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000659
MGI:MGI:1347472
MGI:MGI:1347477
PANTHER:PTN000930906
UniProtKB:O00358
UniProtKB:Q9Y261
ZFIN:ZDB-GENE-000616-15

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000659
FB:FBgn0003430
FB:FBgn0004895
FB:FBgn0014143
MGI:MGI:1347466
MGI:MGI:1347472
MGI:MGI:1347476
MGI:MGI:1347477
MGI:MGI:1349428
MGI:MGI:1353569
MGI:MGI:1927549
MGI:MGI:95546
PANTHER:PTN000930906
PomBase:SPBC32H8.11
PomBase:SPBC4C3.12
RGD:2807
RGD:2808
RGD:2809
SGD:S000000661
SGD:S000001393
UniProtKB:O00358
UniProtKB:P55317
UniProtKB:P58012
UniProtKB:Q12948
UniProtKB:Q13461
UniProtKB:Q5AS72
UniProtKB:Q99958
UniProtKB:Q9Y261
WB:WBGene00001434
WB:WBGene00001441
WB:WBGene00002601
WB:WBGene00003017
WB:WBGene00004013
WB:WBGene00006853

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000659
PANTHER:PTN000930906
RGD:621723
UniProtKB:O00358
WB:WBGene00004013
ZFIN:ZDB-GENE-000616-15

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:105095)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(MGI:MGI:105095)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16676

F

Seeded From UniProt

complete

enables

GO:0008301

DNA binding, bending

PMID:7957066[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16676

F

Seeded From UniProt

complete

enables

GO:0008301

DNA binding, bending

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16676

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007411

axon guidance

PMID:15509772[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2180362

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7957066[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16676

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:8666231[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2180362

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:13678594[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16676
ensembl:ENSP00000481581

F

Seeded From UniProt

complete

enables

GO:0008301

DNA binding, bending

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16676
ensembl:ENSP00000481581

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16676
ensembl:ENSP00000481581

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Gumbel, JH et al. (2012) The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice. PLoS ONE 7 e52156 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Zhang, H et al. (2003) Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr. Biol. 13 1625-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Levinson, RS et al. (2005) Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 132 529-39 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. 5.0 5.1 Pierrou, S et al. (1994) Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13 5002-12 PubMed GONUTS page
  6. Herrera, E et al. (2004) Foxd1 is required for proper formation of the optic chiasm. Development 131 5727-39 PubMed GONUTS page
  7. Hatini, V et al. (1996) Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev. 10 1467-78 PubMed GONUTS page