GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HHV1:Q3MU88

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1). (10298)
Gene Name(s) ICP27 (ECO:0000313 with EMBL:BAE44981.1)
Protein Name(s) ICP27 (ECO:0000313 with EMBL:BAE44981.1)
External Links
UniProt Q3MU88
EMBL AB235841
AB235844
AB235845
GO GO:0042025
GO:0046823
GO:0006355
InterPro IPR008648
Pfam PF05459

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046823

negative regulation of nucleocytoplasmic transport

PMID:22334672[1]

ECO:0000314

P

Figure 8 demonstrates the way that this protein is able to block NLS and M9-mediated nucleocytoplasmic transport pathways in the host

complete
CACAO 6349

GO:0042025

host cell nucleus

PMID:22334672[1]

ECO:0000315

C

Fig. 9 shows the effects that different mutations have on the protein's ability to localize to the nucleus

complete
CACAO 6350

involved_in

GO:0046823

negative regulation of nucleocytoplasmic transport

PMID:22334672[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0042025

host cell nucleus

PMID:22334672[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008648

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Malik, P et al. (2012) Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways. J. Biol. Chem. 287 12277-92 PubMed GONUTS page