MOUSE:RIF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rif1
Protein Name(s)	Telomere-associated protein RIF1 Rap1-interacting factor 1 homolog mRif1
External Links
UniProt	Q6PR54
EMBL	AY428571 AY585206 AK017618 AK083291 AK088688 BC055320
CCDS	CCDS50583.1
RefSeq	NP_780447.4 XP_006498240.1 XP_006498241.1
UniGene	Mm.254530 Mm.389247
BioGrid	206234
DIP	DIP-54907N
IntAct	Q6PR54
PhosphoSite	Q6PR54
MaxQB	Q6PR54
PaxDb	Q6PR54
PRIDE	Q6PR54
Ensembl	ENSMUST00000069794 ENSMUST00000112693
GeneID	51869
KEGG	mmu:51869
UCSC	uc008jqr.1 uc008jqt.1
CTD	55183
MGI	MGI:1098622
eggNOG	NOG87885
GeneTree	ENSGT00390000012204
HOGENOM	HOG000231777
HOVERGEN	HBG080431
InParanoid	Q6PR54
KO	K11138
OMA	PTESVYP
OrthoDB	EOG70GMDW
TreeFam	TF323789
ChiTaRS	Rif1
NextBio	308166
PRO	PR:Q6PR54
Proteomes	UP000000589
Bgee	Q6PR54
CleanEx	MM_RIF1
ExpressionAtlas	Q6PR54
Genevestigator	Q6PR54
GO	GO:0000781 GO:0005737 GO:0001939 GO:0001940 GO:0005730 GO:0005634 GO:0005886 GO:0005819 GO:0007049 GO:0006974 GO:0019827
InterPro	IPR016024 IPR028566 IPR022031
PANTHER	PTHR22928
Pfam	PF12231
SUPFAM	SSF48371

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:23306437^[1]	ECO:0000315			P		Figure 2 The rate and incidence of telomere fusions decrease in cells in the absence of Rif1. In the presence of Rif1, nonhomologous end joining is promoted, which leads to double-stranded break repair.	complete CACAO 6801
part_of	GO:0035861	site of double-strand break	PMID:23306439^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:23306439^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23306437^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	PMID:23306437^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:23333305^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:23333305^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:23333305^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	PMID:23333305^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045830	positive regulation of isotype switching	PMID:23333306^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5UIP0	P		Seeded From UniProt	complete
involved_in	GO:0006348	chromatin silencing at telomere	PMID:24735877^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:24735877^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:23306437^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051574	positive regulation of histone H3-K9 methylation	PMID:24735877^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:24735877^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24735877^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000054272) regulates_transcription_of:(ENSEMBL:ENSMUSG00000070828)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0050085 MGI:MGI:1098622 PANTHER:PTN001116630 PomBase:SPAC6F6.17 UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098622 PANTHER:PTN001116630 PomBase:SPAC6F6.17 SGD:S000000479	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000042	negative regulation of double-strand break repair via homologous recombination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043247	telomere maintenance in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:16518401^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15042697^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036) part_of:(CL:0000007)\|part_of:(EMAPA:16037) part_of:(CL:0000007)\|part_of:(EMAPA:16040) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)\|part_of:(EMAPA:16069) part_of:(CL:0000007)\|part_of:(EMAPA:16062) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
part_of	GO:0001940	male pronucleus	PMID:15042697^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16033)	Seeded From UniProt	complete
part_of	GO:0001939	female pronucleus	PMID:15042697^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16033)	Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5UIP0	C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:15042697^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000352)	Seeded From UniProt	complete
involved_in	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	P		Seeded From UniProt	complete
involved_in	GO:2000042	negative regulation of double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	P		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
involved_in	GO:0043247	telomere maintenance in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5UIP0 ensembl:ENSP00000243326	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zimmermann, M et al. (2013) 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science 339 700-4 PubMed GONUTS page
↑ ^2.0 ^2.1 Di Virgilio, M et al. (2013) Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 339 711-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Chapman, JR et al. (2013) RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 49 858-71 PubMed GONUTS page
↑ Escribano-Díaz, C et al. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 49 872-83 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Dan, J et al. (2014) Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev. Cell 29 7-19 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ Loh, YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38 431-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Adams, IR & McLaren, A (2004) Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. Dev. Dyn. 229 733-44 PubMed GONUTS page

[PMID:23306437-1] 1.0 ^1.1 ^1.2 ^1.3 Zimmermann, M et al. (2013) 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science 339 700-4 PubMed GONUTS page

[PMID:23306439-2] 2.0 ^2.1 Di Virgilio, M et al. (2013) Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 339 711-5 PubMed GONUTS page

[PMID:23333305-3] 3.0 ^3.1 ^3.2 ^3.3 Chapman, JR et al. (2013) RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 49 858-71 PubMed GONUTS page

[PMID:23333306-4] Escribano-Díaz, C et al. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 49 872-83 PubMed GONUTS page

[PMID:24735877-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Dan, J et al. (2014) Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev. Cell 29 7-19 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20439489-7] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:16518401-8] Loh, YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38 431-40 PubMed GONUTS page

[PMID:15042697-9] 9.0 ^9.1 ^9.2 ^9.3 Adams, IR & McLaren, A (2004) Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. Dev. Dyn. 229 733-44 PubMed GONUTS page

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MOUSE:RIF1

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