MOUSE:GDPD5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gdpd5 (synonyms: Gde2)
Protein Name(s)	Glycerophosphodiester phosphodiesterase domain-containing protein 5 Glycerophosphodiester phosphodiesterase 2
External Links
UniProt	Q640M6
EMBL	AK141189 AK154771 BC024955 BC026428 BC082585
CCDS	CCDS21481.1
RefSeq	NP_958740.2
UniGene	Mm.286317
ProteinModelPortal	Q640M6
SMR	Q640M6
MaxQB	Q640M6
PaxDb	Q640M6
PRIDE	Q640M6
Ensembl	ENSMUST00000037528
GeneID	233552
KEGG	mmu:233552
UCSC	uc009ilo.1
CTD	81544
MGI	MGI:2686926
eggNOG	COG0584
GeneTree	ENSGT00510000046457
HOGENOM	HOG000232101
HOVERGEN	HBG081551
InParanoid	Q640M6
OMA	WCAGVPS
OrthoDB	EOG7F511B
PhylomeDB	Q640M6
TreeFam	TF313692
BRENDA	3.1.4.46
ChiTaRS	Gdpd5
NextBio	381759
PRO	PR:Q640M6
Proteomes	UP000000589
Bgee	Q640M6
Genevestigator	Q640M6
GO	GO:0012505 GO:0030426 GO:0016021 GO:0016020 GO:0048471 GO:0008889 GO:0021895 GO:0006071 GO:0006629 GO:0045746 GO:0031175 GO:0045666 GO:0048505 GO:0021522
Gene3D	3.20.20.190
InterPro	IPR004129 IPR030395 IPR017946
PANTHER	PTHR23344
Pfam	PF03009
SUPFAM	SSF51695
PROSITE	PS51704

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0097038	perinuclear endoplasmic reticulum	PMID:18667693^[1]	ECO:0000314			C		Figure 3	complete CACAO 6819
	GO:0047389	glycerophosphocholine phosphodiesterase activity	PMID:18667693^[1]	ECO:0000314			F		Figure 5	complete CACAO 6887
	GO:0043025	neuronal cell body	PMID:21943603^[2]	ECO:0000314			C		Figure1 E-G' pre E12.5	complete CACAO 6904
	GO:0045666	positive regulation of neuron differentiation	PMID:21943603^[2]	ECO:0000315			P		Figure 2 A, B, D, E, G	complete CACAO 6905
	GO:0045787	positive regulation of cell cycle	PMID:21943603^[2]	ECO:0000315			P		Figure 2, H-N	complete CACAO 6906
	GO:0045746	negative regulation of Notch signaling pathway	PMID:21943603^[2]	ECO:0000315			P		Figure 7 A, B, D, E	complete CACAO 6907
	GO:0045746	negative regulation of Notch signaling pathway	PMID:21943603^[2]	ECO:0000314			P		Figure 7 J–O	complete CACAO 6908
	GO:0045666	positive regulation of neuron differentiation	PMID:23329048^[3]	ECO:0000315			P		Figure 1 (A to H). Lack of GDE2 in spinal cords of mice leads to a loss of spinal motor neurons (MN) and V0 interneurons.	complete CACAO 6931
	GO:0030424	axon	PMID:21943603^[2]	ECO:0000314			C		Fig. 1 H and I (Post E12.5)	complete CACAO 7570
part_of	GO:0030424	axon	PMID:21943603^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:23329048^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	PMID:21943603^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	PMID:21943603^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:21943603^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21943603^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21943603^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0047389	glycerophosphocholine phosphodiesterase activity	PMID:18667693^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	PMID:18667693^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0047389	glycerophosphocholine phosphodiesterase activity	PMID:18667693^[1]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048505	regulation of timing of cell differentiation	PMID:22951639^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5302017	P	regulates_o_occurs_in:(EMAPA:17544) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	PMID:22951639^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5302017	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	PMID:21943603^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5302017	P	regulates_o_occurs_in:(EMAPA:16525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045746	negative regulation of Notch signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q3KTM2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:23329048^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5302017	P	regulates_o_occurs_in:(EMAPA:17577) regulates_o_results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	PMID:17275818^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021895	cerebral cortex neuron differentiation	PMID:22951639^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5302017	P	occurs_in:(EMAPA:17544) results_in_acquisition_of_features_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021522	spinal cord motor neuron differentiation	PMID:21943603^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5302017	P	occurs_in:(EMAPA:16525) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17275818^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008889	glycerophosphodiester phosphodiesterase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q3KTM2	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017946 InterPro:IPR030395	P		Seeded From UniProt	complete
enables	GO:0008081	phosphoric diester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017946 InterPro:IPR030395	F		Seeded From UniProt	complete
enables	GO:0008889	glycerophosphodiester phosphodiesterase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004129	F		Seeded From UniProt	complete
enables	GO:0004435	phosphatidylinositol phospholipase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.11	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-MMU-6814137	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gallazzini, M et al. (2008) GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC. Proc. Natl. Acad. Sci. U.S.A. 105 11026-31 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 Sabharwal, P et al. (2011) GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron 71 1058-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Park, S et al. (2013) GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science 339 324-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Rodriguez, M et al. (2012) Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation. Development 139 3870-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Yanaka, N et al. (2007) Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells. FEBS Lett. 581 712-8 PubMed GONUTS page

[PMID:18667693-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gallazzini, M et al. (2008) GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC. Proc. Natl. Acad. Sci. U.S.A. 105 11026-31 PubMed GONUTS page

[PMID:21943603-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 Sabharwal, P et al. (2011) GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron 71 1058-70 PubMed GONUTS page

[PMID:23329048-3] 3.0 ^3.1 ^3.2 Park, S et al. (2013) GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science 339 324-8 PubMed GONUTS page

[PMID:22951639-4] 4.0 ^4.1 ^4.2 Rodriguez, M et al. (2012) Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation. Development 139 3870-9 PubMed GONUTS page

[PMID:17275818-5] 5.0 ^5.1 Yanaka, N et al. (2007) Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells. FEBS Lett. 581 712-8 PubMed GONUTS page

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MOUSE:GDPD5

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