MOUSE:MTOR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mtor (synonyms: Frap, Frap1)
Protein Name(s)	Serine/threonine-protein kinase mTOR FK506-binding protein 12-rapamycin complex-associated protein 1 FKBP12-rapamycin complex-associated protein Mammalian target of rapamycin mTOR Mechanistic target of rapamycin Rapamycin target protein 1 RAPT1
External Links
UniProt	Q9JLN9
EMBL	AF152838 AL731654 AL713995 AL713995 AL731654 CU210865 BC043920 BC112904 AK012031
CCDS	CCDS18937.1
RefSeq	NP_064393.2
UniGene	Mm.21158
ProteinModelPortal	Q9JLN9
SMR	Q9JLN9
BioGrid	208142
DIP	DIP-40570N
IntAct	Q9JLN9
MINT	MINT-1899010
STRING	10090.ENSMUSP00000099510
BindingDB	Q9JLN9
ChEMBL	CHEMBL1255165
PhosphoSite	Q9JLN9
MaxQB	Q9JLN9
PaxDb	Q9JLN9
PRIDE	Q9JLN9
Ensembl	ENSMUST00000057580 ENSMUST00000103221
GeneID	56717
KEGG	mmu:56717
UCSC	uc008vur.2
CTD	2475
MGI	MGI:1928394
eggNOG	COG5032
GeneTree	ENSGT00760000119382
HOGENOM	HOG000163215
HOVERGEN	HBG005744
InParanoid	Q9JLN9
KO	K07203
OMA	MSRNKEQ
OrthoDB	EOG7CCBQ4
PhylomeDB	Q9JLN9
TreeFam	TF105134
Reactome	REACT_196588 REACT_213550 REACT_226151 REACT_226341 REACT_241655 REACT_255725 REACT_260675 REACT_261840
ChiTaRS	Mtor
NextBio	313190
PRO	PR:Q9JLN9
Proteomes	UP000000589
Bgee	Q9JLN9
Genevestigator	Q9JLN9
GO	GO:0005737 GO:0005829 GO:0030425 GO:0005789 GO:0000139 GO:0005765 GO:0005764 GO:0005741 GO:0043025 GO:0005634 GO:0016605 GO:0031931 GO:0031932 GO:0005524 GO:0008144 GO:0016301 GO:0004674 GO:0043022 GO:0001030 GO:0001031 GO:0001032 GO:0030030 GO:0071456 GO:0031669 GO:0007281 GO:0010507 GO:0045792 GO:0016242 GO:0051534 GO:0018105 GO:0018107 GO:0030838 GO:0001938 GO:0010592 GO:0046889 GO:0010831 GO:0050731 GO:0051897 GO:0051496 GO:0045945 GO:0045727 GO:0046777 GO:0006468 GO:0043610 GO:0031998 GO:0005979 GO:0031641 GO:0045859 GO:0032314 GO:0032095 GO:0043200 GO:0032868 GO:0031529 GO:0031929
Gene3D	1.10.1070.11 1.20.120.150 1.25.10.10 1.25.40.10
InterPro	IPR011989 IPR016024 IPR024585 IPR003152 IPR011009 IPR000403 IPR018936 IPR003151 IPR014009 IPR009076 IPR011990
Pfam	PF11865 PF02259 PF02260 PF00454 PF08771
SMART	SM00146
SUPFAM	SSF47212 SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS00915 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0055006	cardiac cell development	PMID:23342106^[1]	ECO:0000315			P		Figure 1: Mutant is embryotic lethal	complete CACAO 6764
	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	PMID:23429704^[2]	ECO:0000314			P		Figure 2. HeLa cells exhibited a higher rate of de novo pyrimidine synthesis in the presence of growth factors and amino acids. It was then concluded that mTORC1 activates de novo pyrimidine synthesis.	complete CACAO 7005
involved_in	GO:1904059	regulation of locomotor rhythm	PMID:29750810^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0005635	nuclear envelope	PMID:25294810^[4]	ECO:0000314			C		Figure 2A shows immunostaining of mTOR in the nuclear envelope.	complete CACAO 11483
involved_in	GO:0042752	regulation of circadian rhythm	PMID:29750810^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	PMID:12718876^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:26160071^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000554A4F_10090	P	occurs_in:(CL:0000746) negatively_regulates:(GO:0006914)	Seeded From UniProt	complete
involved_in	GO:0045670	regulation of osteoclast differentiation	PMID:19440205^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	PMID:23429704^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055006	cardiac cell development	PMID:23342106^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:16915281^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
enables	GO:0043022	ribosome binding	PMID:21045808^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	PMID:21258367^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	PMID:16915281^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:21258367^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16915281^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21258367^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038202	TORC1 signaling	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0021796 PANTHER:PTN000124327 PomBase:SPBC216.07c UniProtKB:P42345	P		Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0021796 PANTHER:PTN000124327 PomBase:SPBC30D10.10c UniProtKB:P42345 WB:WBGene00002583 dictyBase:DDB_G0281569	C		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0021796 MGI:MGI:1928394 PANTHER:PTN000124327 PomBase:SPBC216.07c RGD:68371 UniProtKB:P42345 WB:WBGene00002583	C		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0021796 MGI:MGI:1928394 PANTHER:PTN000124327 UniProtKB:P42345	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928394 PANTHER:PTN000124327 PomBase:SPBC216.07c RGD:68371 SGD:S000001686 SGD:S000003827 UniProtKB:P42345 UniProtKB:Q9FR53	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0045035 FB:FBgn0053554 MGI:MGI:104779 MGI:MGI:1928394 PANTHER:PTN000124197 RGD:1593265 RGD:68371 SGD:S000000340 SGD:S000001141 SGD:S000003827 UniProtKB:P78527 UniProtKB:Q13315 UniProtKB:Q96Q15 UniProtKB:Q9FR53 UniProtKB:Q9Y4A5 WB:WBGene00000226 WB:WBGene00007028	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928394 PANTHER:PTN000124327 PomBase:SPBC216.07c PomBase:SPBC30D10.10c RGD:68371 SGD:S000001686 SGD:S000003827 UniProtKB:P42345	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990253	cellular response to leucine starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904213	negative regulation of iodide transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904206	positive regulation of skeletal muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904197	positive regulation of granulosa cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904193	negative regulation of cholangiocyte apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904058	positive regulation of sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904056	positive regulation of cholangiocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904000	positive regulation of eating behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903691	positive regulation of wound healing, spreading of epidermal cells	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099547	regulation of translation at synapse, modulating synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090559	regulation of membrane permeability	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071233	cellular response to leucine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	PMID:18347059^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060048	cardiac muscle contraction	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055013	cardiac muscle cell development	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051896	regulation of protein kinase B signaling	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	PMID:15467718^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050882	voluntary musculoskeletal movement	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050769	positive regulation of neurogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:15467718^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048738	cardiac muscle tissue development	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:25411504^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179311,MGI:MGI:3850506	P	regulates_o_occurs_in:(EMAPA:16894) occurs_in:(CL:0002453)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048255	mRNA stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046889	positive regulation of lipid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:15467718^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045945	positive regulation of transcription by RNA polymerase III	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045859	regulation of protein kinase activity	PMID:15185396^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929183	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045792	negative regulation of cell size	PMID:16286931^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929183	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045792	negative regulation of cell size	PMID:15185396^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929183	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045792	negative regulation of cell size	PMID:16286931^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045727	positive regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045727	positive regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043610	regulation of carbohydrate utilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043278	response to morphine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043200	response to amino acid	PMID:15467718^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043200	response to amino acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043087	regulation of GTPase activity	PMID:15467718^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042220	response to cocaine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038202	TORC1 signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034198	cellular response to amino acid starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032868	response to insulin	PMID:15467718^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032095	regulation of response to food	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031998	regulation of fatty acid beta-oxidation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	PMID:15467718^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	PMID:15467718^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031929	TOR signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031667	response to nutrient levels	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031641	regulation of myelination	PMID:24101522^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031529	ruffle organization	PMID:15467718^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030838	positive regulation of actin filament polymerization	PMID:15467718^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030838	positive regulation of actin filament polymerization	PMID:15467718^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:23836929^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030030	cell projection organization	PMID:16286931^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030030	cell projection organization	PMID:16286931^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42346	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021510	spinal cord development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	PMID:11707573^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:18347059^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(MGI:MGI:1920431)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016310	phosphorylation	PMID:25327288^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016310	phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:25327288^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:15467718^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016242	negative regulation of macroautophagy	PMID:23274896^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016242	negative regulation of macroautophagy	PMID:16714284^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016242	negative regulation of macroautophagy	PMID:25327288^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014736	negative regulation of muscle atrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014042	positive regulation of neuron maturation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010831	positive regulation of myotube differentiation	PMID:19704009^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2445183	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	PMID:15467718^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009267	cellular response to starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008361	regulation of cell size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007616	long-term memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007584	response to nutrient	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:12140361^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15467718^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006112	energy reserve metabolic process	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006109	regulation of carbohydrate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0005979	regulation of glycogen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18347059^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18381428^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18347059^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18347059^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057) has_direct_input:(MGI:MGI:1920431)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11707573^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003179	heart valve morphogenesis	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
involved_in	GO:0002296	T-helper 1 cell lineage commitment	PMID:26410627^[27]	ECO:0006052	RNAi evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:25139234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3850506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68371	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:17556672^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001558	regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	P		Seeded From UniProt	complete
enables	GO:0001156	TFIIIC-class transcription factor complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
enables	GO:0001032	RNA polymerase III type 3 promoter DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
enables	GO:0001031	RNA polymerase III type 2 promoter DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
enables	GO:0001030	RNA polymerase III type 1 promoter DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42345	F		Seeded From UniProt	complete
involved_in	GO:1990253	cellular response to leucine starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:1903691	positive regulation of wound healing, spreading of epidermal cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0071233	cellular response to leucine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0045945	positive regulation of transcription by RNA polymerase III	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
involved_in	GO:0038202	TORC1 signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	C		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	C		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	C		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0008361	regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	P		Seeded From UniProt	complete
enables	GO:0001156	TFIIIC-class transcription factor complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
enables	GO:0001032	RNA polymerase III type 3 promoter DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
enables	GO:0001031	RNA polymerase III type 2 promoter DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
enables	GO:0001030	RNA polymerase III type 1 promoter DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42345 ensembl:ENSP00000354558	F		Seeded From UniProt	complete
involved_in	GO:1904213	negative regulation of iodide transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1904206	positive regulation of skeletal muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1904197	positive regulation of granulosa cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1904193	negative regulation of cholangiocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1904058	positive regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1904056	positive regulation of cholangiocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1904000	positive regulation of eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0099547	regulation of translation at synapse, modulating synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0048255	mRNA stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	F		Seeded From UniProt	complete
involved_in	GO:0043610	regulation of carbohydrate utilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0031998	regulation of fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
part_of	GO:0031931	TORC1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	F		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0014736	negative regulation of muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0014042	positive regulation of neuron maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0006109	regulation of carbohydrate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0005979	regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42346 ensembl:ENSRNOP00000014167	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026683	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009076 InterPro:IPR036738	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhu, Y et al. (2013) Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS ONE 8 e54221 PubMed GONUTS page
↑ ^2.0 ^2.1 Robitaille, AM et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339 1320-3 PubMed GONUTS page
↑ ^3.0 ^3.1 Ramanathan, C et al. (2018) mTOR signaling regulates central and peripheral circadian clock function. PLoS Genet. 14 e1007369 PubMed GONUTS page
↑ Kazyken, D et al. (2014) The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget 5 9577-93 PubMed GONUTS page
↑ Kim, DH et al. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11 895-904 PubMed GONUTS page
↑ Li, Z et al. (2017) miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 24 1205-1213 PubMed GONUTS page
↑ Smink, JJ et al. (2009) Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 28 1769-81 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Bernardi, R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442 779-85 PubMed GONUTS page
↑ Oh, WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29 3939-51 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Kim, J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 132-41 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 Zhang, P et al. (2014) Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochem. Biophys. Res. Commun. 452 53-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Yang, TT et al. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell. Biol. 28 3489-501 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page
↑ Zou, Y et al. (2014) Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J. Neurosci. 34 15764-78 PubMed GONUTS page
↑ ^16.0 ^16.1 Uhlmann, EJ et al. (2004) Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 47 180-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Tavazoie, SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8 1727-34 PubMed GONUTS page
↑ Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page
↑ Sosanya, NM et al. (2013) Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. J. Cell Biol. 202 53-69 PubMed GONUTS page
↑ ^20.0 ^20.1 Hentges, KE et al. (2001) FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc. Natl. Acad. Sci. U.S.A. 98 13796-801 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
↑ Bachar-Wikstrom, E et al. (2013) Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes 62 1227-37 PubMed GONUTS page
↑ Cao, Y et al. (2006) Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J. Biol. Chem. 281 20483-93 PubMed GONUTS page
↑ Liu, GH et al. (2009) Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol. Cell. Biol. 29 5800-12 PubMed GONUTS page
↑ De Miguel, MP et al. (2002) Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A. 99 10458-63 PubMed GONUTS page
↑ Pearson, HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res. 68 2223-32 PubMed GONUTS page
↑ Ray, JP et al. (2015) The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity 43 690-702 PubMed GONUTS page
↑ Otulakowski, G et al. (2007) Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia. Am. J. Respir. Cell Mol. Biol. 37 457-66 PubMed GONUTS page

[PMID:23342106-1] 1.0 ^1.1 Zhu, Y et al. (2013) Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS ONE 8 e54221 PubMed GONUTS page

[PMID:23429704-2] 2.0 ^2.1 Robitaille, AM et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339 1320-3 PubMed GONUTS page

[PMID:29750810-3] 3.0 ^3.1 Ramanathan, C et al. (2018) mTOR signaling regulates central and peripheral circadian clock function. PLoS Genet. 14 e1007369 PubMed GONUTS page

[PMID:25294810-4] Kazyken, D et al. (2014) The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget 5 9577-93 PubMed GONUTS page

[PMID:12718876-5] Kim, DH et al. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11 895-904 PubMed GONUTS page

[PMID:26160071-6] Li, Z et al. (2017) miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 24 1205-1213 PubMed GONUTS page

[PMID:19440205-7] Smink, JJ et al. (2009) Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 28 1769-81 PubMed GONUTS page

[PMID:16915281-8] 8.0 ^8.1 ^8.2 Bernardi, R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442 779-85 PubMed GONUTS page

[PMID:21045808-9] Oh, WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29 3939-51 PubMed GONUTS page

[PMID:21258367-10] 10.0 ^10.1 ^10.2 Kim, J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13 132-41 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25139234-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 Zhang, P et al. (2014) Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochem. Biophys. Res. Commun. 452 53-9 PubMed GONUTS page

[PMID:18347059-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Yang, TT et al. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell. Biol. 28 3489-501 PubMed GONUTS page

[PMID:15467718-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page

[PMID:25411504-15] Zou, Y et al. (2014) Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J. Neurosci. 34 15764-78 PubMed GONUTS page

[PMID:15185396-16] 16.0 ^16.1 Uhlmann, EJ et al. (2004) Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 47 180-8 PubMed GONUTS page

[PMID:16286931-17] 17.0 ^17.1 ^17.2 ^17.3 Tavazoie, SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8 1727-34 PubMed GONUTS page

[PMID:24101522-18] Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page

[PMID:23836929-19] Sosanya, NM et al. (2013) Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1. J. Cell Biol. 202 53-69 PubMed GONUTS page

[PMID:11707573-20] 20.0 ^20.1 Hentges, KE et al. (2001) FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc. Natl. Acad. Sci. U.S.A. 98 13796-801 PubMed GONUTS page

[PMID:25327288-21] 21.0 ^21.1 ^21.2 Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page

[PMID:23274896-22] Bachar-Wikstrom, E et al. (2013) Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes 62 1227-37 PubMed GONUTS page

[PMID:16714284-23] Cao, Y et al. (2006) Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J. Biol. Chem. 281 20483-93 PubMed GONUTS page

[PMID:19704009-24] Liu, GH et al. (2009) Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol. Cell. Biol. 29 5800-12 PubMed GONUTS page

[PMID:12140361-25] De Miguel, MP et al. (2002) Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A. 99 10458-63 PubMed GONUTS page

[PMID:18381428-26] Pearson, HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res. 68 2223-32 PubMed GONUTS page

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