PMID:23342106

Citation	Zhu, Y, Pires, KM, Whitehead, KJ, Olsen, CD, Wayment, B, Zhang, YC, Bugger, H, Ilkun, O, Litwin, SE, Thomas, G, Kozma, SC and Abel, ED (2013) Mechanistic target of rapamycin (mtor) is essential for murine embryonic heart development and growth. PLoS ONE 8:e54221
Abstract	Mechanistic target of rapamycin (Mtor) is required for embryonic inner cell mass proliferation during early development. However, Mtor expression levels are very low in the mouse heart during embryogenesis. To determine if Mtor plays a role during mouse cardiac development, cardiomyocyte specific Mtor deletion was achieved using α myosin heavy chain (α-MHC) driven Cre recombinase. Initial mosaic expression of Cre between embryonic day (E) 10.5 and E11.5 eliminated a subset of cardiomyocytes with high Cre activity by apoptosis and reduced overall cardiac proliferative capacity. The remaining cardiomyocytes proliferated and expanded normally. However loss of 50% of cardiomyocytes defined a threshold that impairs the ability of the embryonic heart to sustain the embryo's circulatory requirements. As a result 92% of embryos with cardiomyocyte Mtor deficiency died by the end of gestation. Thus Mtor is required for survival and proliferation of cardiomyocytes in the developing heart.
Links	PubMed PMC3544830 Online version:10.1371/journal.pone.0054221
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:MTOR		GO:0055006: cardiac cell development	ECO:0000315:		P		Figure 1: Mutant is embryotic lethal	complete CACAO 6764
MOUSE:MTOR	involved_in	GO:0055006: cardiac cell development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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