MOUSE:NMDZ1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grin1 (synonyms: Glurz1)
Protein Name(s)	Glutamate receptor ionotropic, NMDA 1 GluN1 Glutamate [NMDA] receptor subunit zeta-1 N-methyl-D-aspartate receptor subunit NR1 NMD-R1
External Links
UniProt	P35438
EMBL	D10028 AL732309 AL732309 BC039157
CCDS	CCDS15764.1 CCDS50528.1
PIR	S21104
RefSeq	NP_001171127.1 NP_001171128.1 NP_032195.1
UniGene	Mm.278672
ProteinModelPortal	P35438
SMR	P35438
BioGrid	200067
DIP	DIP-31577N
IntAct	P35438
MINT	MINT-135802
GuidetoPHARMACOLOGY	455
PhosphoSite	P35438
MaxQB	P35438
PaxDb	P35438
PRIDE	P35438
Ensembl	ENSMUST00000028335 ENSMUST00000114312
GeneID	14810
KEGG	mmu:14810
UCSC	uc008iri.2 uc008irk.2
CTD	2902
MGI	MGI:95819
eggNOG	NOG282132
GeneTree	ENSGT00760000119186
HOGENOM	HOG000231491
HOVERGEN	HBG052638
InParanoid	P35438
KO	K05208
TreeFam	TF351405
Reactome	REACT_198244 REACT_198248 REACT_257656 REACT_258217
NextBio	286995
PRO	PR:P35438
Proteomes	UP000000589
Bgee	P35438
CleanEx	MM_GRIN1
ExpressionAtlas	P35438
Genevestigator	P35438
GO	GO:0030054 GO:0009986 GO:0005737 GO:0030425 GO:0032590 GO:0043197 GO:0005783 GO:0060076 GO:0030426 GO:0016020 GO:0017146 GO:0097481 GO:0014069 GO:0045211 GO:0045202 GO:0043083 GO:0008021 GO:0043195 GO:0005262 GO:0005509 GO:0005516 GO:0005261 GO:0005234 GO:0016595 GO:0016594 GO:0004972 GO:0042165 GO:0005102 GO:0022843 GO:0008344 GO:0008306 GO:0055074 GO:0070588 GO:0006816 GO:0098655 GO:0006812 GO:0006874 GO:0071287 GO:0021987 GO:0001661 GO:0034220 GO:0035235 GO:0007612 GO:0007611 GO:0007616 GO:0060179 GO:0007613 GO:0043524 GO:0050905 GO:0008355 GO:0021586 GO:0043065 GO:2000463 GO:0045944 GO:0060134 GO:0018964 GO:0051262 GO:0050770 GO:0010646 GO:0048814 GO:0060079 GO:0048169 GO:0042391 GO:0043523 GO:0048168 GO:0043576 GO:0051963 GO:0048167 GO:0007585 GO:0001975 GO:0051592 GO:0045471 GO:0060992 GO:0043278 GO:0048511 GO:0019233 GO:0035176 GO:0001964 GO:0001967 GO:0007268 GO:0035249 GO:0008542
InterPro	IPR001828 IPR018882 IPR019594 IPR001508 IPR001320 IPR028082
Pfam	PF01094 PF10562 PF00060
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030425	dendrite	PMID:17229826^[1]	ECO:0000315			C		Wild type primary dendrites show labelling of NR1 by using immunofluorescence techniques, figure 6A. Figure 6B in reelin mutant mice showed decrease NR1 which was corrected by treating with reelin, figure 6C.	complete CACAO 2394
	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000315			C		Cell surface protein biotinylation and Western blotting was used, figure 3 A-C.	complete CACAO 2397
enables	GO:0016594	glycine binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35439	F		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35439	P		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:18728179^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(CL:1001474)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:19726645^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0043197) part_of:(CL:0002608) part_of:(UBERON:0014556)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17229826^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018964	propylene metabolic process	PMID:21795692^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:10480904^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	PMID:12586454^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:19726645^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19726645^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010399 MGI:MGI:95819 PANTHER:PTN001451205 RGD:2736 UniProtKB:Q05586	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010399 MGI:MGI:95819 PANTHER:PTN001451205 RGD:2736 UniProtKB:Q05586	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905429	response to glycine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	P		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903539	protein localization to postsynaptic membrane	PMID:12676993^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P	has_input:(MGI:MGI:95820) has_input:(MGI:MGI:95821)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902952	positive regulation of dendritic spine maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900149	positive regulation of Schwann cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060179	male mating behavior	PMID:10481908^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060134	prepulse inhibition	PMID:15265649^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:14645471^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95821	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:15003177^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055074	calcium ion homeostasis	PMID:7907365^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051963	regulation of synapse assembly	PMID:12657691^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2655232 MGI:MGI:2655237	P	regulates_o_has_participant:(EMAPA:35163) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051262	protein tetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:8313466^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	PMID:15745956^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P	regulates_o_occurs_in:(EMAPA:17576) regulates_o_occurs_in:(CL:0000540)\|regulates_o_occurs_in:(EMAPA:35163) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048814	regulation of dendrite morphogenesis	PMID:15745956^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P	regulates_o_occurs_in:(EMAPA:17576) regulates_o_occurs_in:(CL:0000540)\|regulates_o_occurs_in:(EMAPA:35163) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048511	rhythmic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:17313573^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448952,MGI:MGI:3611337	P	regulates_o_occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:17015831^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3692441	P	regulates_o_occurs_in:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:10818139^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928283 MGI:MGI:1928284	P	regulates_o_occurs_in:(EMAPA:32845) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048168	regulation of neuronal synaptic plasticity	PMID:15576450^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178083,MGI:MGI:2181422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:9246451^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:8980239^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P	regulates_o_has_participant:(EMAPA:32768) regulates_o_has_participant:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:8980238^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P	regulates_o_has_participant:(EMAPA:32768) regulates_o_has_participant:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:15003177^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P	regulates_o_has_participant:(EMAPA:17544)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7907365^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17787) regulates_o_occurs_in:(CL:0000117) has_regulation_target:(MGI:MGI:102935)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:15317856^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12890763^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:11754836^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000451)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21734292^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16710293^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16025111^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14645471^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15978582^[30]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35439	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[31]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35439	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35439	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
part_of	GO:0044307	dendritic branch	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043576	regulation of respiratory gaseous exchange	PMID:10777815^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:17077143^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	occurs_in:(EMAPA:35883)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:17077143^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P	occurs_in:(EMAPA:35883)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:10479699^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95815	P	regulates_o_occurs_in:(EMAPA:35217) regulates_o_occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:16906136^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P	regulates_o_occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043278	response to morphine	PMID:18423864^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:15663482^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:17803966^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096575 MGI:MGI:95820	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:8060614^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:17313573^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448952,MGI:MGI:3611337	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:15576450^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178083,MGI:MGI:2181422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:12832526^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:12657691^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2655232 MGI:MGI:2655237	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:12040087^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2387441	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	P		Seeded From UniProt	complete
enables	GO:0042165	neurotransmitter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:8313466^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P	occurs_in:(EMAPA:35883)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:10963597^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:1928281	P	occurs_in:(EMAPA:35163)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	PMID:16025111^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:10481908^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928280	P		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:23395379^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	C		Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	F		Seeded From UniProt	complete
enables	GO:0022843	voltage-gated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:12657691^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2655232 MGI:MGI:2655237	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:10963597^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:1928281	P	results_in_development_of:(EMAPA:35163)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021586	pons maturation	PMID:8313466^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P	results_in_maturation_of:(EMAPA:35883)	Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:12832526^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:9003035^[44]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35436 UniProtKB:Q01097	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	F		Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9003035^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8840015^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17093100^[46]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:10846156^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:24069373^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:15748150^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:15317856^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010646	regulation of cell communication	PMID:16299502^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P	regulates_o_has_participant:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010524	positive regulation of calcium ion transport into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:9054942^[51]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97306	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:9246451^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:8980238^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:17313573^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448952,MGI:MGI:3611337	P	has_participant:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:16611824^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:10818139^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928283 MGI:MGI:1928284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008355	olfactory learning	PMID:11248114^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008355	olfactory learning	PMID:10700255^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:10818139^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928283 MGI:MGI:1928284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:10481908^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:21813695^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:99578	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:12718863^[56]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2387441	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:12040087^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2387441	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:10846156^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007616	long-term memory	PMID:15003177^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:17556551^[57]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:10719900^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:10700255^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2177650	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:17015831^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3692441	P	has_participant:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:17004940^[59]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2387441	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007585	respiratory gaseous exchange	PMID:8713451^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007585	respiratory gaseous exchange	PMID:8313466^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:8060614^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928327	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000598)\|occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:15576450^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178083,MGI:MGI:2181422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006812	cation transport	PMID:7531804^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95821	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006812	cation transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16814779^[62]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17787)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12414093^[63]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:15663482^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:15663482^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:1374164^[64]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95820	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:1374164^[64]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:7531804^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95821	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11754835^[65]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54763	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:7531804^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95821	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1377365^[66]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95822	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1377365^[66]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95821	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1377365^[66]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95820	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1374164^[64]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95820	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:8313466^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	F	occurs_in:(EMAPA:35883)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:8060614^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928327	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)\|occurs_in:(EMAPA:32845) occurs_in:(CL:0000598)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:17313573^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448952,MGI:MGI:3611337	F	occurs_in:(EMAPA:19037) occurs_in:(CL:0000120)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:15745956^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	F	occurs_in:(EMAPA:35163) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12832526^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279	F	occurs_in:(EMAPA:35790) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12040087^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279,MGI:MGI:2387441	F	occurs_in:(EMAPA:32770) occurs_in:(CL:0000598)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:10963597^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1385220^[67]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1377365^[66]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1374164^[64]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:7929101^[68]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35439	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
contributes_to	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q05586	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001975	response to amphetamine	PMID:21368124^[69]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99578	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001975	response to amphetamine	PMID:16638606^[70]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928280	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001975	response to amphetamine	PMID:15467708^[71]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928280	P	has_participant:(EMAPA:35357)\|has_participant:(EMAPA:35242)\|has_participant:(EMAPA:32672)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:8713451^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:8313466^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:10777815^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928270	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:10818139^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928283 MGI:MGI:1928284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001661	conditioned taste aversion	PMID:16101757^[72]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928279 MGI:MGI:3038374	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
involved_in	GO:1905429	response to glycine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	P		Seeded From UniProt	complete
involved_in	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	P		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	C		Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	C		Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	F		Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05586 ensembl:ENSP00000360608	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:1532151^[73]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:1532151^[73]	ECO:0000305	curator inference used in manual assertion	GO:0004972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:1532151^[73]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:1532151^[73]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1532151^[73]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004972	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-3928635 Reactome:R-MMU-3928613	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:10846156^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page
↑ Ohtsuka, N et al. (2008) Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc. Natl. Acad. Sci. U.S.A. 105 12961-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Akashi, K et al. (2009) NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J. Neurosci. 29 10869-82 PubMed GONUTS page
↑ Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ Chen, LT et al. (1999) A candidate target for G protein action in brain. J. Biol. Chem. 274 26931-8 PubMed GONUTS page
↑ Kiefer, F et al. (2003) Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol. Biol. Psychiatry 53 345-51 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Mohn, AR et al. (1999) Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98 427-36 PubMed GONUTS page
↑ Duncan, GE et al. (2004) Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behav. Brain Res. 153 507-19 PubMed GONUTS page
↑ ^11.0 ^11.1 Köhr, G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J. Neurosci. 23 10791-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Cui, Z et al. (2004) Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41 781-93 PubMed GONUTS page
↑ ^13.0 ^13.1 Bulleit, RF et al. (1994) NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1. J. Neurosci. 14 1584-95 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Rudhard, Y et al. (2003) Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J. Neurosci. 23 2323-32 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Li, Y et al. (1994) Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76 427-37 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Lee, LJ et al. (2005) NMDA receptor-dependent regulation of axonal and dendritic branching. J. Neurosci. 25 2304-11 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Niewoehner, B et al. (2007) Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur. J. Neurosci. 25 837-46 PubMed GONUTS page
↑ ^18.0 ^18.1 Dang, MT et al. (2006) Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 103 15254-9 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Kew, JN et al. (2000) Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J. Neurosci. 20 4037-49 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Pawlak, V et al. (2005) Impaired synaptic scaling in mouse hippocampal neurones expressing NMDA receptors with reduced calcium permeability. J. Physiol. (Lond.) 562 771-83 PubMed GONUTS page
↑ ^21.0 ^21.1 Tonegawa, S et al. (1996) Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. Cold Spring Harb. Symp. Quant. Biol. 61 225-38 PubMed GONUTS page
↑ McHugh, TJ et al. (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87 1339-49 PubMed GONUTS page
↑ ^23.0 ^23.1 Tsien, JZ et al. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87 1327-38 PubMed GONUTS page
↑ ^24.0 ^24.1 Abe, M et al. (2004) NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J. Neurosci. 24 7292-304 PubMed GONUTS page
↑ Tao, YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J. Neurosci. 23 6703-12 PubMed GONUTS page
↑ Henderson, JT et al. (2001) The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron 32 1041-56 PubMed GONUTS page
↑ Tang, M et al. (2011) Neto1 is an auxiliary subunit of native synaptic kainate receptors. J. Neurosci. 31 10009-18 PubMed GONUTS page
↑ Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page
↑ ^29.0 ^29.1 Snyder, EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 1051-8 PubMed GONUTS page
↑ Burkhardt, C et al. (2005) Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett. 579 3821-8 PubMed GONUTS page
↑ Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ ^32.0 ^32.1 Poon, CS et al. (2000) NMDA receptor activity in utero averts respiratory depression and anomalous long-term depression in newborn mice. J. Neurosci. 20 RC73 PubMed GONUTS page
↑ ^33.0 ^33.1 de Rivero Vaccari, JC et al. (2006) NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death. Proc. Natl. Acad. Sci. U.S.A. 103 16971-6 PubMed GONUTS page
↑ Jensen, P et al. (1999) Rescue of cerebellar granule cells from death in weaver NR1 double mutants. J. Neurosci. 19 7991-8 PubMed GONUTS page
↑ Tashiro, A et al. (2006) NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442 929-33 PubMed GONUTS page
↑ Quintero, GC et al. (2008) Evaluation of morphine analgesia and motor coordination in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1-subunit. Neurosci. Lett. 437 55-8 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Amparan, D et al. (2005) Direct interaction of myosin regulatory light chain with the NMDA receptor. J. Neurochem. 92 349-61 PubMed GONUTS page
↑ Taniura, H et al. (2007) Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation. Biochem. Biophys. Res. Commun. 362 1096-100 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 Forrest, D et al. (1994) Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron 13 325-38 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 South, SM et al. (2003) A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J. Neurosci. 23 5031-40 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 Nakazawa, K et al. (2002) Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297 211-8 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 Iwasato, T et al. (2000) Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 406 726-31 PubMed GONUTS page
↑ Jurado, S et al. (2013) LTP requires a unique postsynaptic SNARE fusion machinery. Neuron 77 542-58 PubMed GONUTS page
↑ ^44.0 ^44.1 Chazot, PL & Stephenson, FA (1997) Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J. Neurochem. 68 507-16 PubMed GONUTS page
↑ Snell, LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res. Mol. Brain Res. 40 71-8 PubMed GONUTS page
↑ Lai, C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J. Neurosci. 26 11798-806 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 Setou, M et al. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288 1796-802 PubMed GONUTS page
↑ Breiderhoff, T et al. (2013) Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE 8 e75006 PubMed GONUTS page
↑ Trinidad, JC et al. (2005) Phosphorylation state of postsynaptic density proteins. J. Neurochem. 92 1306-16 PubMed GONUTS page
↑ Arumugam, H et al. (2005) NMDA receptors regulate developmental gap junction uncoupling via CREB signaling. Nat. Neurosci. 8 1720-6 PubMed GONUTS page
↑ Silva, AJ et al. (1997) A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat. Genet. 15 281-4 PubMed GONUTS page
↑ Rondi-Reig, L et al. (2006) Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation. J. Neurosci. 26 4071-81 PubMed GONUTS page
↑ Rondi-Reig, L et al. (2001) CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task. Proc. Natl. Acad. Sci. U.S.A. 98 3543-8 PubMed GONUTS page
↑ ^54.0 ^54.1 Rampon, C et al. (2000) Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat. Neurosci. 3 238-44 PubMed GONUTS page
↑ Parker, JG et al. (2011) The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning. J. Neurosci. 31 11362-9 PubMed GONUTS page
↑ Nakazawa, K et al. (2003) Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron 38 305-15 PubMed GONUTS page
↑ McHugh, TJ et al. (2007) Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 317 94-9 PubMed GONUTS page
↑ Huerta, PT et al. (2000) Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons. Neuron 25 473-80 PubMed GONUTS page
↑ Cravens, CJ et al. (2006) CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. Eur. J. Neurosci. 24 1771-80 PubMed GONUTS page
↑ ^60.0 ^60.1 Tokita, Y et al. (1996) Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells. Eur. J. Neurosci. 8 69-78 PubMed GONUTS page
↑ ^61.0 ^61.1 ^61.2 Tsuzuki, K et al. (1994) Ion permeation properties of the cloned mouse epsilon 2/zeta 1 NMDA receptor channel. Brain Res. Mol. Brain Res. 26 37-46 PubMed GONUTS page
↑ Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page
↑ Puyal, J et al. (2002) Distribution of alpha-amino-3-hydroxy-5-methyl-4 isoazolepropionic acid and N-methyl-D-aspartate receptor subunits in the vestibular and spiral ganglia of the mouse during early development. Brain Res. Dev. Brain Res. 139 51-7 PubMed GONUTS page
↑ ^64.0 ^64.1 ^64.2 ^64.3 Meguro, H et al. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357 70-4 PubMed GONUTS page
↑ Grunwald, IC et al. (2001) Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32 1027-40 PubMed GONUTS page
↑ ^66.0 ^66.1 ^66.2 ^66.3 Kutsuwada, T et al. (1992) Molecular diversity of the NMDA receptor channel. Nature 358 36-41 PubMed GONUTS page
↑ Ikeda, K et al. (1992) Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 313 34-8 PubMed GONUTS page
↑ Chazot, PL et al. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269 24403-9 PubMed GONUTS page
↑ Beutler, LR et al. (2011) Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc. Natl. Acad. Sci. U.S.A. 108 4206-11 PubMed GONUTS page
↑ Moy, SS et al. (2006) Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function. Brain Res. 1089 186-94 PubMed GONUTS page
↑ Miyamoto, S et al. (2004) Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction. Neuropsychopharmacology 29 2180-8 PubMed GONUTS page
↑ Cui, Z et al. (2005) Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout. Eur. J. Neurosci. 22 755-63 PubMed GONUTS page
↑ ^73.0 ^73.1 ^73.2 ^73.3 ^73.4 Yamazaki, M et al. (1992) Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 300 39-45 PubMed GONUTS page

[PMID:17229826-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page

[PMID:18728179-2] Ohtsuka, N et al. (2008) Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc. Natl. Acad. Sci. U.S.A. 105 12961-6 PubMed GONUTS page

[PMID:19726645-3] 3.0 ^3.1 ^3.2 Akashi, K et al. (2009) NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J. Neurosci. 29 10869-82 PubMed GONUTS page

[PMID:21795692-4] Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:10480904-5] Chen, LT et al. (1999) A candidate target for G protein action in brain. J. Biol. Chem. 274 26931-8 PubMed GONUTS page

[PMID:12586454-6] Kiefer, F et al. (2003) Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol. Biol. Psychiatry 53 345-51 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12676993-8] Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page

[PMID:10481908-9] 9.0 ^9.1 ^9.2 Mohn, AR et al. (1999) Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98 427-36 PubMed GONUTS page

[PMID:15265649-10] Duncan, GE et al. (2004) Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behav. Brain Res. 153 507-19 PubMed GONUTS page

[PMID:14645471-11] 11.0 ^11.1 Köhr, G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J. Neurosci. 23 10791-9 PubMed GONUTS page

[PMID:15003177-12] 12.0 ^12.1 ^12.2 Cui, Z et al. (2004) Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41 781-93 PubMed GONUTS page

[PMID:7907365-13] 13.0 ^13.1 Bulleit, RF et al. (1994) NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1. J. Neurosci. 14 1584-95 PubMed GONUTS page

[PMID:12657691-14] 14.0 ^14.1 ^14.2 Rudhard, Y et al. (2003) Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J. Neurosci. 23 2323-32 PubMed GONUTS page

[PMID:8313466-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Li, Y et al. (1994) Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76 427-37 PubMed GONUTS page

[PMID:15745956-16] 16.0 ^16.1 ^16.2 Lee, LJ et al. (2005) NMDA receptor-dependent regulation of axonal and dendritic branching. J. Neurosci. 25 2304-11 PubMed GONUTS page

[PMID:17313573-17] 17.0 ^17.1 ^17.2 ^17.3 Niewoehner, B et al. (2007) Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur. J. Neurosci. 25 837-46 PubMed GONUTS page

[PMID:17015831-18] 18.0 ^18.1 Dang, MT et al. (2006) Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 103 15254-9 PubMed GONUTS page

[PMID:10818139-19] 19.0 ^19.1 ^19.2 ^19.3 Kew, JN et al. (2000) Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J. Neurosci. 20 4037-49 PubMed GONUTS page

[PMID:15576450-20] 20.0 ^20.1 ^20.2 Pawlak, V et al. (2005) Impaired synaptic scaling in mouse hippocampal neurones expressing NMDA receptors with reduced calcium permeability. J. Physiol. (Lond.) 562 771-83 PubMed GONUTS page

[PMID:9246451-21] 21.0 ^21.1 Tonegawa, S et al. (1996) Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. Cold Spring Harb. Symp. Quant. Biol. 61 225-38 PubMed GONUTS page

[PMID:8980239-22] McHugh, TJ et al. (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87 1339-49 PubMed GONUTS page

[PMID:8980238-23] 23.0 ^23.1 Tsien, JZ et al. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87 1327-38 PubMed GONUTS page

[PMID:15317856-24] 24.0 ^24.1 Abe, M et al. (2004) NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J. Neurosci. 24 7292-304 PubMed GONUTS page

[PMID:12890763-25] Tao, YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J. Neurosci. 23 6703-12 PubMed GONUTS page

[PMID:11754836-26] Henderson, JT et al. (2001) The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron 32 1041-56 PubMed GONUTS page

[PMID:21734292-27] Tang, M et al. (2011) Neto1 is an auxiliary subunit of native synaptic kainate receptors. J. Neurosci. 31 10009-18 PubMed GONUTS page

[PMID:16710293-28] Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page

[PMID:16025111-29] 29.0 ^29.1 Snyder, EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 1051-8 PubMed GONUTS page

[PMID:15978582-30] Burkhardt, C et al. (2005) Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett. 579 3821-8 PubMed GONUTS page

[PMID:15681343-31] Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:10777815-32] 32.0 ^32.1 Poon, CS et al. (2000) NMDA receptor activity in utero averts respiratory depression and anomalous long-term depression in newborn mice. J. Neurosci. 20 RC73 PubMed GONUTS page

[PMID:17077143-33] 33.0 ^33.1 de Rivero Vaccari, JC et al. (2006) NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death. Proc. Natl. Acad. Sci. U.S.A. 103 16971-6 PubMed GONUTS page

[PMID:10479699-34] Jensen, P et al. (1999) Rescue of cerebellar granule cells from death in weaver NR1 double mutants. J. Neurosci. 19 7991-8 PubMed GONUTS page

[PMID:16906136-35] Tashiro, A et al. (2006) NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442 929-33 PubMed GONUTS page

[PMID:18423864-36] Quintero, GC et al. (2008) Evaluation of morphine analgesia and motor coordination in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1-subunit. Neurosci. Lett. 437 55-8 PubMed GONUTS page

[PMID:15663482-37] 37.0 ^37.1 ^37.2 Amparan, D et al. (2005) Direct interaction of myosin regulatory light chain with the NMDA receptor. J. Neurochem. 92 349-61 PubMed GONUTS page

[PMID:17803966-38] Taniura, H et al. (2007) Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation. Biochem. Biophys. Res. Commun. 362 1096-100 PubMed GONUTS page

[PMID:8060614-39] 39.0 ^39.1 ^39.2 Forrest, D et al. (1994) Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron 13 325-38 PubMed GONUTS page

[PMID:12832526-40] 40.0 ^40.1 ^40.2 South, SM et al. (2003) A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J. Neurosci. 23 5031-40 PubMed GONUTS page

[PMID:12040087-41] 41.0 ^41.1 ^41.2 Nakazawa, K et al. (2002) Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297 211-8 PubMed GONUTS page

[PMID:10963597-42] 42.0 ^42.1 ^42.2 Iwasato, T et al. (2000) Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 406 726-31 PubMed GONUTS page

[PMID:23395379-43] Jurado, S et al. (2013) LTP requires a unique postsynaptic SNARE fusion machinery. Neuron 77 542-58 PubMed GONUTS page

[PMID:9003035-44] 44.0 ^44.1 Chazot, PL & Stephenson, FA (1997) Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J. Neurochem. 68 507-16 PubMed GONUTS page

[PMID:8840015-45] Snell, LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res. Mol. Brain Res. 40 71-8 PubMed GONUTS page

[PMID:17093100-46] Lai, C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J. Neurosci. 26 11798-806 PubMed GONUTS page

[PMID:10846156-47] 47.0 ^47.1 ^47.2 Setou, M et al. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288 1796-802 PubMed GONUTS page

[PMID:24069373-48] Breiderhoff, T et al. (2013) Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE 8 e75006 PubMed GONUTS page

[PMID:15748150-49] Trinidad, JC et al. (2005) Phosphorylation state of postsynaptic density proteins. J. Neurochem. 92 1306-16 PubMed GONUTS page

[PMID:16299502-50] Arumugam, H et al. (2005) NMDA receptors regulate developmental gap junction uncoupling via CREB signaling. Nat. Neurosci. 8 1720-6 PubMed GONUTS page

[PMID:9054942-51] Silva, AJ et al. (1997) A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat. Genet. 15 281-4 PubMed GONUTS page

[PMID:16611824-52] Rondi-Reig, L et al. (2006) Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation. J. Neurosci. 26 4071-81 PubMed GONUTS page

[PMID:11248114-53] Rondi-Reig, L et al. (2001) CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task. Proc. Natl. Acad. Sci. U.S.A. 98 3543-8 PubMed GONUTS page

[PMID:10700255-54] 54.0 ^54.1 Rampon, C et al. (2000) Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat. Neurosci. 3 238-44 PubMed GONUTS page

[PMID:21813695-55] Parker, JG et al. (2011) The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning. J. Neurosci. 31 11362-9 PubMed GONUTS page

[PMID:12718863-56] Nakazawa, K et al. (2003) Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron 38 305-15 PubMed GONUTS page

[PMID:17556551-57] McHugh, TJ et al. (2007) Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 317 94-9 PubMed GONUTS page

[PMID:10719900-58] Huerta, PT et al. (2000) Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons. Neuron 25 473-80 PubMed GONUTS page

[PMID:17004940-59] Cravens, CJ et al. (2006) CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. Eur. J. Neurosci. 24 1771-80 PubMed GONUTS page

[PMID:8713451-60] 60.0 ^60.1 Tokita, Y et al. (1996) Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells. Eur. J. Neurosci. 8 69-78 PubMed GONUTS page

[PMID:7531804-61] 61.0 ^61.1 ^61.2 Tsuzuki, K et al. (1994) Ion permeation properties of the cloned mouse epsilon 2/zeta 1 NMDA receptor channel. Brain Res. Mol. Brain Res. 26 37-46 PubMed GONUTS page

[PMID:16814779-62] Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page

[PMID:12414093-63] Puyal, J et al. (2002) Distribution of alpha-amino-3-hydroxy-5-methyl-4 isoazolepropionic acid and N-methyl-D-aspartate receptor subunits in the vestibular and spiral ganglia of the mouse during early development. Brain Res. Dev. Brain Res. 139 51-7 PubMed GONUTS page

[PMID:1374164-64] 64.0 ^64.1 ^64.2 ^64.3 Meguro, H et al. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357 70-4 PubMed GONUTS page

[PMID:11754835-65] Grunwald, IC et al. (2001) Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32 1027-40 PubMed GONUTS page

[PMID:1377365-66] 66.0 ^66.1 ^66.2 ^66.3 Kutsuwada, T et al. (1992) Molecular diversity of the NMDA receptor channel. Nature 358 36-41 PubMed GONUTS page

[PMID:1385220-67] Ikeda, K et al. (1992) Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 313 34-8 PubMed GONUTS page

[PMID:7929101-68] Chazot, PL et al. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269 24403-9 PubMed GONUTS page

[PMID:21368124-69] Beutler, LR et al. (2011) Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc. Natl. Acad. Sci. U.S.A. 108 4206-11 PubMed GONUTS page

[PMID:16638606-70] Moy, SS et al. (2006) Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function. Brain Res. 1089 186-94 PubMed GONUTS page

[PMID:15467708-71] Miyamoto, S et al. (2004) Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction. Neuropsychopharmacology 29 2180-8 PubMed GONUTS page

[PMID:16101757-72] Cui, Z et al. (2005) Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout. Eur. J. Neurosci. 22 755-63 PubMed GONUTS page

[PMID:1532151-73] 73.0 ^73.1 ^73.2 ^73.3 ^73.4 Yamazaki, M et al. (1992) Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 300 39-45 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

[54]

[55]

[56]

[57]

[58]

[59]

[60]

[61]

[62]

[63]

[64]

[65]

[66]

[67]

[68]

[69]

[70]

[71]

[72]

[73]

MOUSE:NMDZ1

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools