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PMID:8980238
| Citation |
Tsien, JZ, Huerta, PT and Tonegawa, S (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87:1327-38 |
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| Abstract |
We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories. |
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| Keywords |
Animals; Behavior, Animal/physiology; Dentate Gyrus/physiology; Genetic Engineering/methods; Genetic Vectors; Hippocampus/physiology; In Situ Hybridization; Long-Term Potentiation; Memory/physiology; Mice; Mice, Knockout; Neuronal Plasticity/physiology; Receptors, N-Methyl-D-Aspartate/physiology; Synaptic Transmission |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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