PMID:1377365

Citation	Kutsuwada, T, Kashiwabuchi, N, Mori, H, Sakimura, K, Kushiya, E, Araki, K, Meguro, H, Masaki, H, Kumanishi, T and Arakawa, M (1992) Molecular diversity of the NMDA receptor channel. Nature 358:36-41
Abstract	Two novel subunits of the mouse NMDA receptor channel, the epsilon 2 and epsilon 3 subunits, have been identified by cloning and expression of complementary DNAs. The heteromeric epsilon 1/zeta 1, epsilon 2/zeta 1 and epsilon 3/zeta 1 NMDA receptor channels exhibit distinct functional properties in affinities for agonists and sensitivities to competitive antagonists and Mg2+ block. In contrast to the wide distribution of the epsilon 1 and zeta 1 subunit messenger RNAs in the brain, the epsilon 2 subunit mRNA is expressed only in the forebrain and the epsilon 3 subunit mRNA is found predominantly in the cerebellum. The epsilon 1/zeta 1 and epsilon 2/zeta 1 channels expressed in Xenopus oocytes, but not the epsilon 3/zeta 1 channel, are activated by treatment with 12-O-tetradecanoylphorbol 13-acetate. These findings suggest that the molecular diversity of the epsilon subunit family underlies the functional heterogeneity of the NMDA receptor channel.
Links	PubMed Online version:10.1038/358036a0
Keywords	Amino Acid Sequence; Animals; Brain/physiology; Cloning, Molecular; DNA/genetics; Gene Expression; Ion Channel Gating/drug effects; Ion Channels/chemistry; Ion Channels/physiology; Mice; Molecular Sequence Data; Nucleic Acid Hybridization; RNA, Messenger/genetics; Receptors, N-Methyl-D-Aspartate/chemistry; Receptors, N-Methyl-D-Aspartate/drug effects; Receptors, N-Methyl-D-Aspartate/physiology; Recombinant Proteins; Sequence Alignment; Tetradecanoylphorbol Acetate/pharmacology
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