GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10777815
| Citation |
Poon, CS, Zhou, Z and Champagnat, J (2000) NMDA receptor activity in utero averts respiratory depression and anomalous long-term depression in newborn mice. J. Neurosci. 20:RC73 |
|---|---|
| Abstract |
Mutant mice lacking NMDA receptor 1 subunit (NR1) showed marked depression of respiratory and suckling activities in vivo and overexpression of synaptic long-term depression (LTD) in a brainstem cardiorespiratory-related region (nucleus tractus solitarius) in vitro. Pharmacological blockade of NMDA receptors in normal newborn mice mimicked the depression in suckling activity but not respiratory depression in vivo or brainstem LTD in vitro. Results at the behavioral and cellular levels demonstrate that NMDA receptor deficiency during prenatal development may unleash an anomalous form of NMDA receptor-independent LTD along with life-threatening respiratory depression consequences in the newborn. These findings raise the specter of cardiorespiratory dysregulation with increased risks of morbidity and mortality in the infant as a result of premature births or genetic or drug-induced NMDA receptor antagonism during pregnancy. |
| Links | |
| Keywords |
Animals; Animals, Newborn/genetics; Animals, Newborn/physiology; Brain Stem/physiopathology; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Neuronal Plasticity/genetics; Pregnancy; Pregnancy, Animal/genetics; Pregnancy, Animal/physiology; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/genetics; Respiratory Insufficiency/genetics; Respiratory Insufficiency/physiopathology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
