PMID:17556551

Citation	McHugh, TJ, Jones, MW, Quinn, JJ, Balthasar, N, Coppari, R, Elmquist, JK, Lowell, BB, Fanselow, MS, Wilson, MA and Tonegawa, S (2007) Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 317:94-9
Abstract	Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts. A significant reduction in the context-specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another. These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation.
Links	PubMed Online version:10.1126/science.1140263
Keywords	Animals; Behavior, Animal; Conditioning (Psychology); Cues; Dentate Gyrus/cytology; Dentate Gyrus/physiology; Discrimination (Psychology); Excitatory Postsynaptic Potentials; Fear; Hippocampus/cytology; Hippocampus/physiology; Learning/physiology; Maze Learning; Memory/physiology; Mice; Mice, Knockout; Neuronal Plasticity; Pattern Recognition, Physiological; Perforant Pathway; Pyramidal Cells/physiology; Receptors, N-Methyl-D-Aspartate/genetics; Receptors, N-Methyl-D-Aspartate/physiology; Recombination, Genetic; Synaptic Transmission
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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