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PMID:16814779
| Citation |
Miyazaki, T, Hashimoto, K, Uda, A, Sakagami, H, Nakamura, Y, Saito, SY, Nishi, M, Kume, H, Tohgo, A, Kaneko, I, Kondo, H, Fukunaga, K, Kano, M, Watanabe, M and Takeshima, H (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580:4057-64 |
|---|---|
| Abstract |
By DNA cloning, we have identified the BSRP (brain-specific receptor-like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and localized in the endoplasmic reticulum (ER). Expression levels of BSRPs seemed to fluctuate greatly during postnatal cerebellar maturation. Triple-knockout mice lacking BSRP members exhibited motor discoordination, and Purkinje cells (PCs) were often innervated by multiple climbing fibers with different neuronal origins in the mutant cerebellum. Moreover, the phosphorylation levels of protein kinase Calpha (PKCalpha) were significantly downregulated in the mutant cerebellum. Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs. |
| Links |
PubMed Online version:10.1016/j.febslet.2006.06.043 |
| Keywords |
Animals; Cerebellum/cytology; Cerebellum/growth & development; Dendrites/metabolism; Down-Regulation/genetics; Enzyme Activation/genetics; Genome/physiology; Mice; Mice, Knockout; Mice, Neurologic Mutants; Multigene Family/physiology; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/metabolism; Phosphorylation; Protein Kinase C-alpha/metabolism; Protein Processing, Post-Translational/genetics; Psychomotor Performance/physiology; Purkinje Cells/cytology; Purkinje Cells/physiology; Receptors, Glutamate/metabolism; Signal Transduction/physiology; Synapses/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
MOUSE:VIAAT |
part_of |
GO:0060077: inhibitory synapse |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:CALB1 |
part_of |
GO:0045202: synapse |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0036289: peptidyl-serine autophosphorylation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
MOUSE:GRIA2 |
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045202: synapse |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
MOUSE:SE6L2 |
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:SE6L2 |
part_of |
GO:0043025: neuronal cell body |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:SE6L2 |
acts_upstream_of_or_within |
GO:0008344: adult locomotory behavior |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:SE6L2 |
acts_upstream_of_or_within |
GO:0021680: cerebellar Purkinje cell layer development |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:SE6L2 |
acts_upstream_of_or_within |
GO:0090036: regulation of protein kinase C signaling |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
|
Seeded From UniProt |
complete |
|
MOUSE:SE6L2 |
acts_upstream_of_or_within |
GO:0060074: synapse maturation |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
|
Seeded From UniProt |
complete |
|
MOUSE:GRIK5 |
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
MOUSE:SE6L1 |
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:SE6L1 |
part_of |
GO:0043025: neuronal cell body |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:SE6L1 |
acts_upstream_of_or_within |
GO:0008344: adult locomotory behavior |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:SE6L1 |
acts_upstream_of_or_within |
GO:0021680: cerebellar Purkinje cell layer development |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:SE6L1 |
acts_upstream_of_or_within |
GO:0090036: regulation of protein kinase C signaling |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
|
Seeded From UniProt |
complete |
|
MOUSE:SE6L1 |
acts_upstream_of_or_within |
GO:0060074: synapse maturation |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:104745 |
P |
|
Seeded From UniProt |
complete |
|
MOUSE:SEZ6 |
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:SEZ6 |
part_of |
GO:0043025: neuronal cell body |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | |
|
MOUSE:SEZ6 |
acts_upstream_of_or_within |
GO:0008344: adult locomotory behavior |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1935121 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:SEZ6 |
acts_upstream_of_or_within |
GO:0021680: cerebellar Purkinje cell layer development |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1935121 |
P |
Seeded From UniProt |
complete | |
|
MOUSE:SEZ6 |
acts_upstream_of_or_within |
GO:0090036: regulation of protein kinase C signaling |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1935121 |
P |
|
Seeded From UniProt |
complete |
|
MOUSE:SEZ6 |
acts_upstream_of_or_within |
GO:0060074: synapse maturation |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1935121 |
P |
|
Seeded From UniProt |
complete |
|
part_of |
GO:0045202: synapse |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(CL:0000121) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17787) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17787) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17787) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783: endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17787) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0036289: peptidyl-serine autophosphorylation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
occurs_in:(EMAPA:17787) |
Seeded From UniProt |
complete | ||
Notes
See also
References
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