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PMID:16814779

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Citation

Miyazaki, T, Hashimoto, K, Uda, A, Sakagami, H, Nakamura, Y, Saito, SY, Nishi, M, Kume, H, Tohgo, A, Kaneko, I, Kondo, H, Fukunaga, K, Kano, M, Watanabe, M and Takeshima, H (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580:4057-64

Abstract

By DNA cloning, we have identified the BSRP (brain-specific receptor-like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and localized in the endoplasmic reticulum (ER). Expression levels of BSRPs seemed to fluctuate greatly during postnatal cerebellar maturation. Triple-knockout mice lacking BSRP members exhibited motor discoordination, and Purkinje cells (PCs) were often innervated by multiple climbing fibers with different neuronal origins in the mutant cerebellum. Moreover, the phosphorylation levels of protein kinase Calpha (PKCalpha) were significantly downregulated in the mutant cerebellum. Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs.

Links

PubMed Online version:10.1016/j.febslet.2006.06.043

Keywords

Animals; Cerebellum/cytology; Cerebellum/growth & development; Dendrites/metabolism; Down-Regulation/genetics; Enzyme Activation/genetics; Genome/physiology; Mice; Mice, Knockout; Mice, Neurologic Mutants; Multigene Family/physiology; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/metabolism; Phosphorylation; Protein Kinase C-alpha/metabolism; Protein Processing, Post-Translational/genetics; Psychomotor Performance/physiology; Purkinje Cells/cytology; Purkinje Cells/physiology; Receptors, Glutamate/metabolism; Signal Transduction/physiology; Synapses/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:VIAAT

part_of

GO:0060077: inhibitory synapse

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000121)

Seeded From UniProt

complete

MOUSE:CALB1

part_of

GO:0045202: synapse

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000121)

Seeded From UniProt

complete

MOUSE:KPCA

acts_upstream_of_or_within

GO:0036289: peptidyl-serine autophosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:GRIA1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:GRIA2

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:NMDE1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:NMDZ1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:VGLU1

part_of

GO:0045202: synapse

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000121)

Seeded From UniProt

complete

MOUSE:SE6L2

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L2

part_of

GO:0043025: neuronal cell body

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L2

acts_upstream_of_or_within

GO:0008344: adult locomotory behavior

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:1935121

P

Seeded From UniProt

complete

MOUSE:SE6L2

acts_upstream_of_or_within

GO:0021680: cerebellar Purkinje cell layer development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:1935121

P

Seeded From UniProt

complete

MOUSE:SE6L2

acts_upstream_of_or_within

GO:0090036: regulation of protein kinase C signaling

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:1935121

P

  • regulates_o_occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L2

acts_upstream_of_or_within

GO:0060074: synapse maturation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:1935121

P

  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:GRIK5

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DLG4

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L1

part_of

GO:0043025: neuronal cell body

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L1

acts_upstream_of_or_within

GO:0008344: adult locomotory behavior

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:2385295

P

Seeded From UniProt

complete

MOUSE:SE6L1

acts_upstream_of_or_within

GO:0021680: cerebellar Purkinje cell layer development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:2385295

P

Seeded From UniProt

complete

MOUSE:SE6L1

acts_upstream_of_or_within

GO:0090036: regulation of protein kinase C signaling

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:2385295

P

  • regulates_o_occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SE6L1

acts_upstream_of_or_within

GO:0060074: synapse maturation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104745
MGI:MGI:2385295

P

  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SEZ6

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SEZ6

part_of

GO:0043025: neuronal cell body

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SEZ6

acts_upstream_of_or_within

GO:0008344: adult locomotory behavior

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1935121
MGI:MGI:2385295

P

Seeded From UniProt

complete

MOUSE:SEZ6

acts_upstream_of_or_within

GO:0021680: cerebellar Purkinje cell layer development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1935121
MGI:MGI:2385295

P

Seeded From UniProt

complete

MOUSE:SEZ6

acts_upstream_of_or_within

GO:0090036: regulation of protein kinase C signaling

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1935121
MGI:MGI:2385295

P

  • regulates_o_occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:SEZ6

acts_upstream_of_or_within

GO:0060074: synapse maturation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1935121
MGI:MGI:2385295

P

  • occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:VGLU1

part_of

GO:0045202: synapse

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0000121)

Seeded From UniProt

complete

MOUSE:NMDE1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:DLG4

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:GRIA1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:NMDZ1

part_of

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:17787)

Seeded From UniProt

complete

MOUSE:KPCA

acts_upstream_of_or_within

GO:0036289: peptidyl-serine autophosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:17787)

Seeded From UniProt

complete

Notes

See also

References

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