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PMID:8980239
| Citation |
McHugh, TJ, Blum, KI, Tsien, JZ, Tonegawa, S and Wilson, MA (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87:1339-49 |
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| Abstract |
To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus, we have applied multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene. We have discovered that although the CA1 pyramidal cells of these mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields. We have also found a striking deficit in the coordinated firing of pairs of neurons tuned to similar spatial locations. Pairs have uncorrelated firing even if their fields overlap. These results demonstrate that NMDA receptor-mediated synaptic plasticity is necessary for the proper representation of space in the CA1 region of the hippocampus. |
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| Keywords |
Action Potentials; Animals; Behavior, Animal/physiology; Electrophysiology; Hippocampus/physiology; Maze Learning/physiology; Memory/physiology; Mice; Mice, Knockout; Neuronal Plasticity/physiology; Receptors, N-Methyl-D-Aspartate/physiology; Space Perception/physiology; Synapses/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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