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PMID:1385220

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Citation

Ikeda, K, Nagasawa, M, Mori, H, Araki, K, Sakimura, K, Watanabe, M, Inoue, Y and Mishina, M (1992) Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 313:34-8

Abstract

The primary structure of a novel subunit of the mouse NMDA (N-methyl-D-aspartate) receptor channel, designated epsilon 4, has been revealed by cloning and sequencing the cDNA. The epsilon 4 subunit shares high amino acid sequence identity with the epsilon 1, epsilon 2 and epsilon 3 subunits of the mouse NMDA receptor channel, thus constituting the epsilon subfamily of the glutamate receptor channel. Expression from cloned cDNAs of the epsilon 4 subunit together with the zeta 1 subunit in Xenopus oocytes yields functional NMDA receptor channels. The epsilon 4/zeta 1 heteromeric channel exhibits high apparent affinities for agonists and low sensitivities to competitive antagonists. The epsilon 4 subunit is thus distinct in functional properties from the epsilon 1, epsilon 2 and epsilon 3 subunits, and contributes further diversity of the NMDA receptor channel.

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Keywords

Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA; Gene Expression; Ion Channels/genetics; Membrane Potentials; Mice; Molecular Sequence Data; Receptors, N-Methyl-D-Aspartate/genetics; Sequence Homology, Amino Acid; Xenopus laevis

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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