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PMID:12586454
| Citation |
Kiefer, F, Jahn, H, Koester, A, Montkowski, A, Reinscheid, RK and Wiedemann, K (2003) Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol. Biol. Psychiatry 53:345-51 |
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| Abstract |
Ethanol antagonizes central effects of glutamate by inhibition of the N-methyl-D-aspartate (NMDA) receptor function. The co-agonist glycine has been shown to reverse alcohol-mediated effects. The aim of this study was to evaluate the influence of the glycine binding site of the NMDA receptor on the behavioral effects of alcohol by investigating mice with an 80% reduced affinity of the NMDA R1 subunit for glycine (Grin1(D481N)). |
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| Keywords |
Alcohol Drinking/genetics; Alcohol Drinking/psychology; Alcoholic Intoxication/psychology; Animals; Anxiety/psychology; Central Nervous System Depressants/adverse effects; Central Nervous System Depressants/blood; Central Nervous System Depressants/pharmacology; Ethanol/adverse effects; Ethanol/blood; Ethanol/pharmacology; Mice; Mice, Transgenic; Motor Activity/drug effects; Psychomotor Performance/drug effects; Receptors, N-Methyl-D-Aspartate/genetics; Receptors, N-Methyl-D-Aspartate/physiology; Substance Withdrawal Syndrome/psychology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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