GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10480904
| Citation |
Chen, LT, Gilman, AG and Kozasa, T (1999) A candidate target for G protein action in brain. J. Biol. Chem. 274:26931-8 |
|---|---|
| Abstract |
An effector candidate for G protein action, GRIN1, was identified by screening a cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1 is a novel protein without substantial homology to known protein domains. It is expressed largely in brain and binds specifically to activated G(z)alpha, G(o)alpha, and G(i)alpha through its carboxyl-terminal region. The protein KIAA0514 (GRIN2) is homologous to GRIN1 at its carboxyl terminus and also binds to activated G(o)alpha. Both GRIN1 and G(o)alpha are membrane-bound proteins that are enriched in the growth cones of neurites. Coexpression of GRIN1 or GRIN2 with activated G(o)alpha causes formation of a network of fine processes in Neuro2a cells, suggesting that these pathways may function downstream of G(o)alpha to control growth of neurites. |
| Links | |
| Keywords |
Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Brain/metabolism; Carrier Proteins/metabolism; Cells, Cultured; Cloning, Molecular; GTP-Binding Proteins/physiology; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Mice; Molecular Sequence Data; Molecular Weight; Nerve Tissue Proteins; Sequence Alignment |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
