PMID:15681343

Citation	Chih, B, Engelman, H and Scheiffele, P (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307:1324-8
Abstract	The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.
Links	PubMed Online version:10.1126/science.1107470
Keywords	Action Potentials; Animals; Cell Adhesion Molecules, Neuronal; Cell Line; Cells, Cultured; Dendrites/physiology; Dendrites/ultrastructure; Down-Regulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Hippocampus/cytology; Membrane Proteins/genetics; Membrane Proteins/metabolism; Membrane Transport Proteins/metabolism; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neural Inhibition; Neurons/physiology; Presynaptic Terminals/physiology; Protein Isoforms; RNA Interference; Rats; Receptors, AMPA/metabolism; Receptors, N-Methyl-D-Aspartate/metabolism; Synapses/physiology; Synaptic Membranes/physiology; Synaptic Transmission; Transfection; Vesicular Glutamate Transport Protein 1; Vesicular Inhibitory Amino Acid Transport Proteins
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