PMID:16611824

Citation	Rondi-Reig, L, Petit, GH, Tobin, C, Tonegawa, S, Mariani, J and Berthoz, A (2006) Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation. J. Neurosci. 26:4071-81
Abstract	The hippocampus is considered to play a role in allocentric but not in egocentric spatial learning. How does this view fit with the emerging evidence that the hippocampus and possibly related cortical areas are necessary for episodic-like memory, i.e., in all situations in which events need to be spatially or sequentially organized? Are NMDA receptor-dependent mechanisms crucial for the acquisition of spatiotemporal relationships? To address this issue, we used knock-out (KO) mice lacking hippocampal CA1 NMDA receptors and presenting a reduction of these receptors in the deep cortical layers (NR1-KO mice). A new task (the starmaze) was designed, allowing us to distinguish allocentric and sequential-egocentric memories. NR1-KO mice were impaired in acquiring both types of memory. Our findings suggest that memories composed of multiple spatiotemporal events require intact NMDA receptors-dependent mechanisms in CA1 and possibly in the deep cortical layers.
Links	PubMed Online version:10.1523/JNEUROSCI.3408-05.2006
Keywords	Animals; Genotype; Hippocampus/physiology; Learning/physiology; Maze Learning/physiology; Memory/physiology; Mice; Mice, Knockout; Motor Activity/physiology; Receptors, N-Methyl-D-Aspartate/deficiency; Receptors, N-Methyl-D-Aspartate/genetics; Receptors, N-Methyl-D-Aspartate/physiology; Reference Values
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