GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:AKT1
Contents
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990418 |
response to insulin-like growth factor stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060416 |
response to growth hormone |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032880 |
regulation of protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P14672) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090201 |
negative regulation of release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071364 |
cellular response to epidermal growth factor stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030334 |
regulation of cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000010 |
positive regulation of protein localization to cell surface |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010975 |
regulation of neuron projection development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009725 |
response to hormone |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003744 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87986 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003091 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17525) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005819 |
spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:19287) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002334) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:19287) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005080 |
protein kinase C binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001893 |
maternal placenta development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675202 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001649 |
osteoblast differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88177 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000402 |
negative regulation of lymphocyte migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1990090 |
cellular response to nerve growth factor stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1990090 |
cellular response to nerve growth factor stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903721 |
positive regulation of I-kappaB phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903038 |
negative regulation of leukocyte cell-cell adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901653 |
cellular response to peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900182 |
positive regulation of protein localization to nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0140052 |
cellular response to oxidised low-density lipoprotein particle stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0097194 |
execution phase of apoptosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0097011 |
cellular response to granulocyte macrophage colony-stimulating factor stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0072656 |
maintenance of protein location in mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0072655 |
establishment of protein localization to mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0071889 |
14-3-3 protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071456 |
cellular response to hypoxia |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071380 |
cellular response to prostaglandin E stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0006096 |
glycolytic process |
ECO:0000315 |
P |
MOUSE AKT1 (AKT) // AKT inhibitor, MK2206, significantly diminished the uptake of glucose and lactate production (Figures 6C and 6D). |
complete | |||||
|
acts_upstream_of_or_within |
GO:0071363 |
cellular response to growth factor stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071276 |
cellular response to cadmium ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071260 |
cellular response to mechanical stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070141 |
response to UV-A |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060716 |
labyrinthine layer blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675202 |
P |
results_in_development_of:(EMAPA:16370) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060709 |
glycogen cell differentiation involved in embryonic placenta development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675202 |
P |
occurs_in:(EMAPA:16370)|occurs_in:(EMAPA:35689) |
Seeded From UniProt |
complete | |
|
enables |
GO:0051721 |
protein phosphatase 2A binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051146 |
striated muscle cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96440 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046889 |
positive regulation of lipid biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046622 |
positive regulation of organ growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2158456 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046326 |
positive regulation of glucose import |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96434 |
P |
has_regulation_target:(MGI:MGI:96434) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0045907 |
positive regulation of vasoconstriction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045861 |
negative regulation of proteolysis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045792 |
negative regulation of cell size |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045737 |
positive regulation of cyclin-dependent protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045725 |
positive regulation of glycogen biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043491 |
protein kinase B signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:102548 |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0043491 |
protein kinase B signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043325 |
phosphatidylinositol-3,4-bisphosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042593 |
glucose homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0038061 |
NIK/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0036294 |
cellular response to decreased oxygen levels |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002334) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035924 |
cellular response to vascular endothelial growth factor stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035655 |
interleukin-18-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035556 |
intracellular signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034614 |
cellular response to reactive oxygen species |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034405 |
response to fluid shear stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032880 |
regulation of protein localization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032880 |
regulation of protein localization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032794 |
GTPase activating protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032287 |
peripheral nervous system myelin maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032270 |
positive regulation of cellular protein metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032094 |
response to food |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032091 |
negative regulation of protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032079 |
positive regulation of endodeoxyribonuclease activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031982 |
vesicle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031641 |
regulation of myelination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030334 |
regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030334 |
regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030307 |
positive regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030307 |
positive regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030235 |
nitric-oxide synthase regulator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030163 |
protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030030 |
cell projection organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0021510 |
spinal cord development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016310 |
phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0014065 |
phosphatidylinositol 3-kinase signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010975 |
regulation of neuron projection development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010918 |
positive regulation of mitochondrial membrane potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010907 |
positive regulation of glucose metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010765 |
positive regulation of sodium ion transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010765 |
positive regulation of sodium ion transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010765 |
positive regulation of sodium ion transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010763 |
positive regulation of fibroblast migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010748 |
negative regulation of long-chain fatty acid import across plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010628 |
positive regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010507 |
negative regulation of autophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010033 |
response to organic substance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008637 |
apoptotic mitochondrial changes |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007568 |
aging |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007281 |
germ cell development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006954 |
inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006924 |
activation-induced cell death of T cells |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006606 |
protein import into nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006412 |
translation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006006 |
glucose metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0005979 |
regulation of glycogen biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0005978 |
glycogen biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2081 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0005977 |
glycogen metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2675202 |
P |
has_participant:(EMAPA:16370)|has_participant:(EMAPA:35689) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B0LPE5 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B0LPE5 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000402 |
negative regulation of lymphocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990090 |
cellular response to nerve growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903721 |
positive regulation of I-kappaB phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903038 |
negative regulation of leukocyte cell-cell adhesion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900182 |
positive regulation of protein localization to nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0140052 |
cellular response to oxidised low-density lipoprotein particle stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072656 |
maintenance of protein location in mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072655 |
establishment of protein localization to mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0071889 |
14-3-3 protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071276 |
cellular response to cadmium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070141 |
response to UV-A |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046889 |
positive regulation of lipid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046326 |
positive regulation of glucose import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045861 |
negative regulation of proteolysis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045737 |
positive regulation of cyclin-dependent protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045725 |
positive regulation of glycogen biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043491 |
protein kinase B signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043325 |
phosphatidylinositol-3,4-bisphosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038061 |
NIK/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035655 |
interleukin-18-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034614 |
cellular response to reactive oxygen species |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034405 |
response to fluid shear stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032079 |
positive regulation of endodeoxyribonuclease activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031982 |
vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030334 |
regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030307 |
positive regulation of cell growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030235 |
nitric-oxide synthase regulator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014065 |
phosphatidylinositol 3-kinase signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010918 |
positive regulation of mitochondrial membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010907 |
positive regulation of glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010748 |
negative regulation of long-chain fatty acid import across plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010507 |
negative regulation of autophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006924 |
activation-induced cell death of T cells |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006606 |
protein import into nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0005979 |
regulation of glycogen biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P31749 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021510 |
spinal cord development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010765 |
positive regulation of sodium ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006412 |
translation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0005978 |
glycogen biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005080 |
protein kinase C binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990090 |
cellular response to nerve growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071260 |
cellular response to mechanical stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051721 |
protein phosphatase 2A binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045907 |
positive regulation of vasoconstriction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045792 |
negative regulation of cell size |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032880 |
regulation of protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032794 |
GTPase activating protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032270 |
positive regulation of cellular protein metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030334 |
regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030307 |
positive regulation of cell growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030212 |
hyaluronan metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P47196 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000961 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043491 |
protein kinase B signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007010 |
cytoskeleton organization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-MMU-1445150 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-MMU-162352 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
Reactome:R-MMU-1445150 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005977 |
glycogen metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005978 |
glycogen biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008643 |
carbohydrate transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Dickey, CA et al. (2008) Akt and CHIP coregulate tau degradation through coordinated interactions. Proc. Natl. Acad. Sci. U.S.A. 105 3622-7 PubMed GONUTS page
- ↑ 2.0 2.1 Laine, J et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 395-407 PubMed GONUTS page
- ↑ 3.0 3.1 Fritzius, T & Moelling, K (2008) Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J. 27 1399-410 PubMed GONUTS page
- ↑ Elia, L et al. (2009) Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation 120 2377-85 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Cong, LN et al. (1997) Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol. Endocrinol. 11 1881-90 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Sun, X et al. (2008) Akt activation prevents Apop-1-induced death of cells. Biochem. Biophys. Res. Commun. 377 1097-101 PubMed GONUTS page
- ↑ Rahman, P et al. (2011) Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton. J. Biol. Chem. 286 29758-70 PubMed GONUTS page
- ↑ 8.0 8.1 Yamashita, K et al. (2001) Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circ. Res. 88 609-14 PubMed GONUTS page
- ↑ Ding, J & Du, K (2009) ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Mol. Cell. Biol. 29 1459-71 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Wakatsuki, S et al. (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat. Cell Biol. 13 1415-23 PubMed GONUTS page
- ↑ Kim, JY et al. (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63 761-73 PubMed GONUTS page
- ↑ 12.0 12.1 Palamarchuk, A et al. (2005) Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res. 65 11282-6 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Mahajan, K et al. (2010) Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS ONE 5 e9646 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Kitamura, T et al. (1999) Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol. Cell. Biol. 19 6286-96 PubMed GONUTS page
- ↑ Cariaga-Martínez, AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open 3 924-36 PubMed GONUTS page
- ↑ Galic, M et al. (2012) External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat. Cell Biol. 14 874-81 PubMed GONUTS page
- ↑ Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page
- ↑ Li, G et al. (2007) Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J. Neurosci. 27 203-11 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page
- ↑ Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page
- ↑ Götz, R et al. (2005) Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat. Neurosci. 8 1169-78 PubMed GONUTS page
- ↑ 23.0 23.1 Sharma, P et al. (2013) Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol. Cancer 12 67 PubMed GONUTS page
- ↑ 24.0 24.1 Zhu, D et al. (2009) Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes. J. Cell. Sci. 122 2760-8 PubMed GONUTS page
- ↑ 25.0 25.1 Xu, J et al. (2002) The role of Asp-462 in regulating Akt activity. J. Biol. Chem. 277 35561-6 PubMed GONUTS page
- ↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
- ↑ Campbell, PA & Rudnicki, MA (2013) Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency. Stem Cells 31 1107-20 PubMed GONUTS page
- ↑ 28.0 28.1 Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page
- ↑ Tuhácková, Z et al. (2004) IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells. Int. J. Mol. Med. 13 601-5 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 Song, J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 5 150-8 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 Yang, ZZ et al. (2003) Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J. Biol. Chem. 278 32124-31 PubMed GONUTS page
- ↑ Mukherjee, A & Rotwein, P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J. Cell. Sci. 122 716-26 PubMed GONUTS page
- ↑ 33.0 33.1 Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
- ↑ Fukasaka, M et al. (2013) Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J. Immunol. 190 5702-11 PubMed GONUTS page
- ↑ Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page
- ↑ Nishimura, K et al. (2017) A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation. Stem Cell Reports 8 787-801 PubMed GONUTS page
- ↑ Giovannone, B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum. Mol. Genet. 18 4629-39 PubMed GONUTS page
- ↑ Lee, H et al. (2013) MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells. PLoS ONE 8 e83471 PubMed GONUTS page
- ↑ 39.0 39.1 Ren, H et al. (2008) IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop. J. Cell Biol. 182 979-91 PubMed GONUTS page
- ↑ Easton, RM et al. (2005) Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol. Cell. Biol. 25 1869-78 PubMed GONUTS page
- ↑ 41.0 41.1 Tavazoie, SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8 1727-34 PubMed GONUTS page
- ↑ Harrington, LS et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166 213-23 PubMed GONUTS page
- ↑ 43.0 43.1 Gleason, CE et al. (2010) Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. Mol. Endocrinol. 24 178-92 PubMed GONUTS page
- ↑ Li, W et al. (2014) PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience 274 153-61 PubMed GONUTS page
- ↑ Haddad, G et al. (2014) Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy. Blood 124 2142-9 PubMed GONUTS page
- ↑ 46.0 46.1 Yasui, T et al. (2012) Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc. Natl. Acad. Sci. U.S.A. 109 21022-7 PubMed GONUTS page
- ↑ 47.0 47.1 47.2 47.3 47.4 Lee, IH et al. (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 282 29866-73 PubMed GONUTS page
- ↑ 48.0 48.1 Auger, R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J. Biol. Chem. 280 28142-51 PubMed GONUTS page
- ↑ Cotter, L et al. (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science 328 1415-8 PubMed GONUTS page
- ↑ 50.0 50.1 Luque, RM & Kineman, RD (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147 2754-63 PubMed GONUTS page
- ↑ Festuccia, WT et al. (2014) Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS ONE 9 e95432 PubMed GONUTS page
- ↑ Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page
- ↑ 53.0 53.1 53.2 Lin, HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21 4037-48 PubMed GONUTS page
- ↑ Fisher, D et al. (2011) Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J. Neurosci. 31 14051-66 PubMed GONUTS page
- ↑ Fuentes-Calvo, I et al. (2013) The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts. Biochim. Biophys. Acta 1833 2734-44 PubMed GONUTS page
- ↑ Kuo, CC et al. (2007) Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide. J. Immunol. 178 6100-8 PubMed GONUTS page
- ↑ Fox, CJ et al. (2003) The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev. 17 1841-54 PubMed GONUTS page
- ↑ De Miguel, MP et al. (2002) Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A. 99 10458-63 PubMed GONUTS page
a
c
- GO:0005516 ! calmodulin binding
- GO:0007249 ! canonical NF-kappaB signal transduction
- GO:0005975 ! carbohydrate metabolic process
- GO:0008643 ! carbohydrate transport
- GO:0005911 ! cell-cell junction
- GO:0032869 ! cellular response to insulin stimulus
- GO:1990090 ! cellular response to nerve growth factor stimulus
- GO:1901653 ! cellular response to peptide
- GO:0140052 ! cellular response to oxidised low-density lipoprotein particle stimulus
- GO:0097011 ! cellular response to granulocyte macrophage colony-stimulating factor stimulus
- GO:0071407 ! cellular response to organic cyclic compound
- GO:0071456 ! cellular response to hypoxia
- GO:0071380 ! cellular response to prostaglandin E stimulus
- GO:0071363 ! cellular response to growth factor stimulus
- GO:0071364 ! cellular response to epidermal growth factor stimulus
- GO:0071276 ! cellular response to cadmium ion
- GO:0071260 ! cellular response to mechanical stimulus
- GO:0036294 ! cellular response to decreased oxygen levels
- GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
- GO:0034614 ! cellular response to reactive oxygen species
- GO:0071356 ! cellular response to tumor necrosis factor
- GO:0002042 ! cell migration involved in sprouting angiogenesis
- GO:0030030 ! cell projection organization
- Chordata
- GO:0036064 ! ciliary basal body
- Craniata
- GO:0005737 ! cytoplasm
- GO:0007010 ! cytoskeleton organization
- GO:0005829 ! cytosol
e
g
- GO:0007281 ! germ cell development
- Glires
- GO:0042593 ! glucose homeostasis
- GO:0006006 ! glucose metabolic process
- GO:0005978 ! glycogen biosynthetic process
- GO:0060709 ! glycogen cell differentiation involved in embryonic placenta development
- GO:0005977 ! glycogen metabolic process
- GO:0006096 ! glycolytic process
- GO:0032794 ! GTPase activating protein binding
i
l
m
n
- GO:0010748 ! negative regulation of long-chain fatty acid import across plasma membrane
- GO:0031397 ! negative regulation of protein ubiquitination
- GO:0031999 ! negative regulation of fatty acid beta-oxidation
- GO:0032091 ! negative regulation of protein binding
- GO:0010951 ! negative regulation of endopeptidase activity
- GO:2000402 ! negative regulation of lymphocyte migration
- GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
- GO:0043066 ! negative regulation of apoptotic process
- GO:0006469 ! negative regulation of protein kinase activity
- GO:0010507 ! negative regulation of autophagy
- GO:0045861 ! negative regulation of proteolysis
- GO:0046329 ! negative regulation of JNK cascade
- GO:0090201 ! negative regulation of release of cytochrome c from mitochondria
- GO:0010629 ! negative regulation of gene expression
- GO:0045792 ! negative regulation of cell size
- GO:0007399 ! nervous system development
- GO:0030235 ! nitric-oxide synthase regulator activity
- GO:0038061 ! non-canonical NF-kappaB signal transduction
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
o
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0032287 ! peripheral nervous system myelin maintenance
- GO:0043325 ! phosphatidylinositol-3,4-bisphosphate binding
- GO:0043491 ! phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0005547 ! phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010918 ! positive regulation of mitochondrial membrane potential
- GO:0010763 ! positive regulation of fibroblast migration
- GO:0010765 ! positive regulation of sodium ion transport
- GO:0010907 ! positive regulation of glucose metabolic process
- GO:0010628 ! positive regulation of gene expression
- GO:0051000 ! positive regulation of nitric-oxide synthase activity
- GO:0045429 ! positive regulation of nitric oxide biosynthetic process
- GO:0030307 ! positive regulation of cell growth
- GO:0048661 ! positive regulation of smooth muscle cell proliferation
- GO:0046889 ! positive regulation of lipid biosynthetic process
- GO:0046622 ! positive regulation of organ growth
- GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle
- GO:0046326 ! positive regulation of D-glucose import
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045907 ! positive regulation of vasoconstriction
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity
- GO:0045725 ! positive regulation of glycogen biosynthetic process
- GO:0045600 ! positive regulation of fat cell differentiation
- GO:0043536 ! positive regulation of blood vessel endothelial cell migration
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0043065 ! positive regulation of apoptotic process
- GO:1900182 ! positive regulation of protein localization to nucleus
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0032270 ! positive regulation of cellular protein metabolic process
- GO:1903078 ! positive regulation of protein localization to plasma membrane
- GO:0032079 ! positive regulation of endodeoxyribonuclease activity
- GO:1903721 ! positive regulation of I-kappaB phosphorylation
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0001938 ! positive regulation of endothelial cell proliferation
- GO:2000010 ! positive regulation of protein localization to cell surface
- GO:0032991 ! protein-containing complex
- GO:0030163 ! protein catabolic process
- GO:0042803 ! protein homodimerization activity
- GO:0006606 ! protein import into nucleus
- GO:0004672 ! protein kinase activity
- GO:0019901 ! protein kinase binding
- GO:0005080 ! protein kinase C binding
- GO:0051721 ! protein phosphatase 2A binding
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
- GO:0004712 ! protein serine/threonine/tyrosine kinase activity
- GO:0016567 ! protein ubiquitination
r
- GO:0031641 ! regulation of myelination
- GO:0032880 ! regulation of protein localization
- GO:0042981 ! regulation of apoptotic process
- GO:0030334 ! regulation of cell migration
- GO:0010975 ! regulation of neuron projection development
- GO:0005979 ! regulation of glycogen biosynthetic process
- GO:0006417 ! regulation of translation
- GO:1990418 ! response to insulin-like growth factor stimulus
- GO:0009725 ! response to hormone
- GO:0006979 ! response to oxidative stress
- GO:0032094 ! response to food
- GO:0034405 ! response to fluid shear stress
- GO:0070141 ! response to UV-A
- GO:0060416 ! response to growth hormone
- Rodentia
s
