GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12869584
| Citation |
Fox, CJ, Hammerman, PS, Cinalli, RM, Master, SR, Chodosh, LA and Thompson, CB (2003) The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev. 17:1841-54 |
|---|---|
| Abstract |
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2. When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli including growth factor withdrawal and endogenous levels of Pim-2 contributed to growth factor-mediated apoptotic resistance. Pim-2 expression maintained cell size and mitochondrial potential independently of the PI3K/Akt/TOR pathway. Pim-2-dependent maintenance of cell size and survival correlated with its ability to maintain rapamycin-resistant phosphorylation of the translational repressor 4E-BP1 and phosphorylation of the BH3 protein BAD. These results establish Pim-2 as a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival. |
| Links |
PubMed PMC196230 Online version:10.1101/gad.1105003 |
| Keywords |
Animals; Antibiotics, Antineoplastic/pharmacology; Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Genetic Vectors; Glucose/metabolism; Glucose/pharmacology; Interleukin-3/metabolism; Lactates/metabolism; Membrane Potentials; Mice; Mitochondria/metabolism; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphorylation; Plasmids/metabolism; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins/physiology; Recombinant Proteins/metabolism; Signal Transduction; Sirolimus/pharmacology; Staurosporine/pharmacology; Thapsigargin/pharmacology; Time Factors; Transcription, Genetic; Transgenes |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
