User:Sanwar

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	HUMAN:FFAR4	2013-02-10 10:59:23 CST	GO:0004930 G-protein coupled receptor activity (F)	PMID:22282525	ECO:0000021 physical interaction evidence	GPR120 is a long chain fatty acid receptor that stimulates hormone release. Calcium mobilization and dynamic mass redistribution (DMR) were used to test receptor ability. Figure 1 showed that amino acid sequenced structure of GPR120. Figures 2 &3 showed the response of the receptor to calcium mobilization while 4 & 5 showed the responses of DMR. The activation of this receptor stimulated calcium mobilization changes as well as DMR through a specific signaling. pathway.	challenge
unacceptable	MOUSE:FFAR4	2013-02-10 12:51:47 CST	GO:0008289 lipid binding (F)	PMID:22279596	ECO:0000314 direct assay evidence used in manual assertion	Injection of certain fatty acids into mice activate a signal transduction pathway through the GPR120 unsaturated fatty acid receptor. Unsaturated fatty acids act as nutritents in the body or act directly in the hypothalamus. Figure 1 shows the experimental procedures used. Figure 4 shows the signal transduction pathway for this receptor. Finally Figure 9 shows the pathway used by the hypothalamus. When the ligand binds, GPR120 activates a pathway that switches off inflammatory pathways that were found in the hypothalamus of obese rats.	challenge
unacceptable	HUMAN:FFAR4	2013-02-10 14:03:40 CST	GO:0007186 G-protein coupled receptor signaling pathway (P)	PMID:22083550	ECO:0000314 direct assay evidence used in manual assertion	GPR120 acts as a medium and a long-chain fatty acid receptor. The GPR120 band was stronger in morbidly obese people (Figure 2). This may be linked to higher mRNA levels in these persons (Figure 3).	challenge
unacceptable	MOUSE:FFAR4	2013-02-10 14:53:52 CST	GO:0008289 lipid binding (F)	PMID:21868624	ECO:0000269 experimental evidence used in manual assertion	Long chain fatty acids are the main activating component of lipids. GPR120, a long chain fatty acid receptor. It is found in taste buds as well as surrounding epithelial cells.It plays a role in human gut fatty acid perception.	challenge
unacceptable	MOUSE:FFAR4	2013-02-10 15:11:29 CST	GO:0007165 signal transduction (P)	PMID:22649399	ECO:0000314 direct assay evidence used in manual assertion	The specific chemical structure of fatty acids have a particular effect on the GPR 120 receptor (Figure 2).	challenge
unacceptable	MOUSE:FFAR4	2013-02-10 15:26:25 CST	GO:0008289 lipid binding (F)	PMID:21901153	ECO:0000270 expression pattern evidence used in manual assertion	GPR120 gene inactivation has led to a decrease in the preference for lipids. The different mRNA transcipts and gene expression were displayed in Figure 1 and 2 respectively. Figure 3 shows how the receptor is regulated by diet.	challenge

acceptable:0
unacceptable:5
requires_changes:1
flagged:0

Annotations challenged by Sanwar

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Alemus, Team Blot Blot Western Baby	HPV11:D7GMV3	GO:0044163 - host cytoskeleton (C)	PMID:15020762	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4 fixed by Surge Pres
updatedbyinstructor	Alemus, Team Blot Blot Western Baby	HPV18:VE2	GO:0044163 - host cytoskeleton (C)	PMID:15020762	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 7
requireschanges	Acapello, Team Blot Blot Western Baby	PSEPK:TOLB	GO:0009279 - cell outer membrane (C)	PMID:10940016	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 6
updatedbyinstructor	Kpatel, Team Llamarmy	DANRE:Q2VF27	GO:0051284 - positive regulation of sequestering of calcium ion (P)	PMID:23376035	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4 fixed by Djgulizia
unacceptable	Ayusol, Team Viral Load Challengers	HUMAN:TRBM	GO:0030195 - negative regulation of blood coagulation (P)	PMID:23383040	ECO:0000269 experimental evidence used in manual assertion	challenge	C: 5

0 annotations fixed by Sanwar

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