DANRE:Q2VF27

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	pkd2 (ECO:0000313 with ZFIN:ZDB-GENE-040827-4)
Protein Name(s)	Polycystin-2 (ECO:0000313 with EMBL:ABA60692.1)
External Links
UniProt	Q2VF27
EMBL	DQ175629
UniGene	Dr.92211
STRING	7955.ENSDARP00000027024
ZFIN	ZDB-GENE-040827-4
eggNOG	NOG325704
HOGENOM	HOG000230858
HOVERGEN	HBG014945
GO	GO:0016020 GO:0005509
Gene3D	1.10.238.10
InterPro	IPR011992 IPR002048 IPR013122 IPR003915
Pfam	PF08016
PRINTS	PR01433
PROSITE	PS50222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0007507	heart development	PMID:23376035^[1]	ECO:0000315			P	Figure 3	complete CACAO 6480
	GO:0051284	positive regulation of sequestering of calcium ion	PMID:23376035^[1]	ECO:0000315			P	Figure 6	complete CACAO 6481
involved_in	GO:0051262	protein tetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P	Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	C	Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	F	Seeded From UniProt	complete
involved_in	GO:0098662	inorganic cation transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P	Seeded From UniProt	complete
involved_in	GO:0198738	cell-cell signaling by wnt	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	P	Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35245	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35245	F	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35245	P	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35245	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35245	P	Seeded From UniProt	complete
involved_in	GO:0051284	positive regulation of sequestering of calcium ion	PMID:23376035^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:23376035^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097704	cellular response to oscillatory fluid shear stress	PMID:25959969^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1193	P	Seeded From UniProt	complete
involved_in	GO:0072114	pronephros morphogenesis	PMID:28769124^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0072114	pronephros morphogenesis	PMID:20168298^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0072019	proximal convoluted tubule development	PMID:19127979^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-4	P	Seeded From UniProt	complete
involved_in	GO:0070121	Kupffer's vesicle development	PMID:26432887^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4 ZFIN:ZDB-MRPHLNO-070620-5 ZFIN:ZDB-MRPHLNO-160201-1	P	Seeded From UniProt	complete
involved_in	GO:0070121	Kupffer's vesicle development	PMID:26432887^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4 ZFIN:ZDB-MRPHLNO-070620-5	P	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:25660539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:25660539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-040830-2	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:24700876^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4 ZFIN:ZDB-MRPHLNO-150814-3	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:21752935^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4 ZFIN:ZDB-MRPHLNO-100823-10	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:20729296^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4 ZFIN:ZDB-MRPHLNO-101122-2	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:19801576^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-2 ZFIN:ZDB-MRPHLNO-100224-1	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:19801576^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-040426-770	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:26839368^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:21752935^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:18695040^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-2	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:18417723^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-3	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:16943304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-2	P	Seeded From UniProt	complete
involved_in	GO:0032965	regulation of collagen biosynthetic process	PMID:20335443^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-4	P	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:16551655^[17]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13563	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:18701462^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:18417723^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	PMID:23376035^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-100715-11	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:19488022^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:21490950^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4 ZFIN:ZDB-MRPHLNO-110527-1	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:25660539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:25660539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-040830-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:20168298^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18417723^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-3	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17360770^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070620-6	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17360770^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070620-5	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17360770^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-870	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17360770^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1193	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:16943304^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-2	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:18701462^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:18417723^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:18417723^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:19801576^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	RefSeq:NM_000297.3	C	Seeded From UniProt	complete
involved_in	GO:0003171	atrioventricular valve development	PMID:25959969^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1193	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18417723^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-3	P	Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	PMID:24767999^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070129-1	P	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:24235270^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060630-4	P	Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1099818 PANTHER:PTN000093539 UniProtKB:E7FKV8 UniProtKB:H2LRU7	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000093539 RGD:1559992 UniProtKB:Q9P0L9 WB:WBGene00004035	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1099818 MGI:MGI:1352448 PANTHER:PTN000093539 UniProtKB:Q8TDX9 UniProtKB:Q9P0L9 WB:WBGene00004035	F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048 InterPro:IPR003915	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003915	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C	Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0313	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Paavola, J et al. (2013) Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J. Mol. Cell. Cardiol. 58 199-208 PubMed GONUTS page
↑ ^2.0 ^2.1 Heckel, E et al. (2015) Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development. Curr. Biol. 25 1354-61 PubMed GONUTS page
↑ Chang, MY et al. (2017) Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency. Sci Rep 7 7161 PubMed GONUTS page
↑ ^4.0 ^4.1 Giamarchi, A et al. (2010) A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 29 1176-91 PubMed GONUTS page
↑ Vasilyev, A et al. (2009) Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 7 e9 PubMed GONUTS page
↑ ^6.0 ^6.1 Roxo-Rosa, M et al. (2015) The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR. Biol Open 4 1356-66 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Yuan, S et al. (2015) Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Curr. Biol. 25 556-67 PubMed GONUTS page
↑ Sussman, CR et al. (2014) Phosphodiesterase 1A modulates cystogenesis in zebrafish. J. Am. Soc. Nephrol. 25 2222-30 PubMed GONUTS page
↑ ^9.0 ^9.1 Rothschild, SC et al. (2011) CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia. Development 138 3387-97 PubMed GONUTS page
↑ Hurd, T et al. (2010) The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Hum. Mol. Genet. 19 4330-44 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Gao, H et al. (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum. Mol. Genet. 19 16-24 PubMed GONUTS page
↑ Zheng, W et al. (2016) Far Upstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 and Suppresses Its Translation. J. Am. Soc. Nephrol. 27 2645-57 PubMed GONUTS page
↑ Köttgen, M et al. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 182 437-47 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Fu, X et al. (2008) The subcellular localization of TRPP2 modulates its function. J. Am. Soc. Nephrol. 19 1342-51 PubMed GONUTS page
↑ ^15.0 ^15.1 Obara, T et al. (2006) Polycystin-2 immunolocalization and function in zebrafish. J. Am. Soc. Nephrol. 17 2706-18 PubMed GONUTS page
↑ Mangos, S et al. () The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Model Mech 3 354-65 PubMed GONUTS page
↑ Streets, AJ et al. (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum. Mol. Genet. 15 1465-73 PubMed GONUTS page
↑ ^18.0 ^18.1 Feng, S et al. (2008) Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J. Biol. Chem. 283 28471-9 PubMed GONUTS page
↑ Yuan, S & Sun, Z (2009) Microinjection of mRNA and morpholino antisense oligonucleotides in zebrafish embryos. J Vis Exp PubMed GONUTS page
↑ Fogelgren, B et al. (2011) The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 7 e1001361 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Schottenfeld, J et al. (2007) Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development 134 1605-15 PubMed GONUTS page
↑ Coxam, B et al. (2014) Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep 7 623-33 PubMed GONUTS page
↑ Aboualaiwi, WA et al. (2014) Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation 129 660-72 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23376035-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Paavola, J et al. (2013) Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J. Mol. Cell. Cardiol. 58 199-208 PubMed GONUTS page

[PMID:25959969-2] 2.0 ^2.1 Heckel, E et al. (2015) Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development. Curr. Biol. 25 1354-61 PubMed GONUTS page

[PMID:28769124-3] Chang, MY et al. (2017) Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency. Sci Rep 7 7161 PubMed GONUTS page

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[PMID:19127979-5] Vasilyev, A et al. (2009) Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 7 e9 PubMed GONUTS page

[PMID:26432887-6] 6.0 ^6.1 Roxo-Rosa, M et al. (2015) The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR. Biol Open 4 1356-66 PubMed GONUTS page

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[PMID:24700876-8] Sussman, CR et al. (2014) Phosphodiesterase 1A modulates cystogenesis in zebrafish. J. Am. Soc. Nephrol. 25 2222-30 PubMed GONUTS page

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[PMID:26839368-12] Zheng, W et al. (2016) Far Upstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 and Suppresses Its Translation. J. Am. Soc. Nephrol. 27 2645-57 PubMed GONUTS page

[PMID:18695040-13] Köttgen, M et al. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 182 437-47 PubMed GONUTS page

[PMID:18417723-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Fu, X et al. (2008) The subcellular localization of TRPP2 modulates its function. J. Am. Soc. Nephrol. 19 1342-51 PubMed GONUTS page

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[PMID:21490950-20] Fogelgren, B et al. (2011) The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 7 e1001361 PubMed GONUTS page

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[PMID:24767999-23] Coxam, B et al. (2014) Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep 7 623-33 PubMed GONUTS page

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