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PMID:25660539

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Citation

Yuan, S, Zhao, L, Brueckner, M and Sun, Z (2015) Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Curr. Biol. 25:556-67

Abstract

Bilateral symmetry during vertebrate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant directional flow of extracellular fluid. However, how ciliary motility is perceived and transduced into asymmetrical intracellular signaling at the LRO remains controversial. Previous work has indicated that sensory cilia and polycystin-2 (Pkd2), a cation channel, are required for sensing ciliary motility, yet their function and the molecular mechanism linking both to left-right signaling cascades are unknown.

Links

PubMed PMC4469357 Online version:10.1016/j.cub.2014.12.051

Keywords

ADP-Ribosylation Factors/metabolism; Analysis of Variance; Animals; Body Patterning/physiology; Calcium Signaling/physiology; Cilia/metabolism; Extracellular Fluid/metabolism; Heterotaxy Syndrome/embryology; Histological Techniques; Humans; Models, Biological; Nodal Signaling Ligands/metabolism; Signal Transduction/physiology; TRPP Cation Channels/metabolism; Zebrafish/embryology; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:PKD2

involved_in

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

DANRE:PKD2

involved_in

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

DANRE:PKD2

involved_in

GO:0061371: determination of heart left/right asymmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

DANRE:PKD2

involved_in

GO:0061371: determination of heart left/right asymmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

DANRE:Q6IVV8

involved_in

GO:0061371: determination of heart left/right asymmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

DANRE:Q6IVV8

involved_in

GO:0061371: determination of heart left/right asymmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

DANRE:Q6IVV8

involved_in

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

DANRE:Q6IVV8

involved_in

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

DANRE:Q2VF27

involved_in

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

DANRE:Q2VF27

involved_in

GO:0007368: determination of left/right symmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

DANRE:Q2VF27

involved_in

GO:0061371: determination of heart left/right asymmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

DANRE:Q2VF27

involved_in

GO:0061371: determination of heart left/right asymmetry

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

Notes

See also

References

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