HUMAN:FFAR4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FFAR4 (synonyms: GPR120, GPR129, O3FAR1, PGR4)
Protein Name(s)	Free fatty acid receptor 4 G-protein coupled receptor 120 G-protein coupled receptor 129 G-protein coupled receptor GT01 G-protein coupled receptor PGR4 Omega-3 fatty acid receptor 1
External Links
UniProt	Q5NUL3
EMBL	AY288417 AB115768 AL356214 AL356214 CH471066 BC101175 AY255573
CCDS	CCDS31248.1 CCDS55720.1
RefSeq	NP_001182684.1 NP_859529.2
UniGene	Hs.661022
ProteinModelPortal	Q5NUL3
SMR	Q5NUL3
STRING	9606.ENSP00000360538
BindingDB	Q5NUL3
ChEMBL	CHEMBL5339
GuidetoPHARMACOLOGY	127
PhosphoSite	Q5NUL3
DMDM	82581671
PaxDb	Q5NUL3
PRIDE	Q5NUL3
Ensembl	ENST00000371481 ENST00000371483
GeneID	338557
KEGG	hsa:338557
UCSC	uc010qnt.2 uc010qnu.2
CTD	338557
GeneCards	GC10P095329
HGNC	HGNC:19061
HPA	HPA042563
MIM	607514 609044
neXtProt	NX_Q5NUL3
PharmGKB	PA134924595
eggNOG	NOG241328
GeneTree	ENSGT00390000009371
HOVERGEN	HBG051775
InParanoid	Q5NUL3
KO	K08425
OMA	YSKILQI
OrthoDB	EOG7PK900
PhylomeDB	Q5NUL3
TreeFam	TF336844
Reactome	REACT_21268 REACT_24019
GeneWiki	GPR120
GenomeRNAi	338557
NextBio	97032
PRO	PR:Q5NUL3
Proteomes	UP000005640
Bgee	Q5NUL3
CleanEx	HS_GPR120
ExpressionAtlas	Q5NUL3
Genevestigator	Q5NUL3
GO	GO:0030139 GO:0016021 GO:0005886 GO:0005504 GO:0008527 GO:0046879 GO:0043066 GO:0050710 GO:0050728 GO:0070374 GO:0010827
InterPro	IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR00237
PROSITE	PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004930	G-protein coupled receptor activity	PMID:22282525^[1]	ECO:0000021			F	GPR120 is a long chain fatty acid receptor that stimulates hormone release. Calcium mobilization and dynamic mass redistribution (DMR) were used to test receptor ability. Figure 1 showed that amino acid sequenced structure of GPR120. Figures 2 &3 showed the response of the receptor to calcium mobilization while 4 & 5 showed the responses of DMR. The activation of this receptor stimulated calcium mobilization changes as well as DMR through a specific signaling. pathway.	Missing: with/from CACAO 6516
	GO:0007186	G-protein coupled receptor signaling pathway	PMID:22083550^[2]	ECO:0000314			P	GPR120 acts as a medium and a long-chain fatty acid receptor. The GPR120 band was stronger in morbidly obese people (Figure 2). This may be linked to higher mRNA levels in these persons (Figure 3).	complete CACAO 6539
	GO:0046879	hormone secretion	PMID:15619630^[3]	ECO:0000314			P	Figure 2A diplays FFA-induced GLP-1 secretion from STC-1 cells	complete CACAO 10523
	GO:0046879	hormone secretion	PMID:15619630^[3]	ECO:0000314			P	Figure 3 displays expression of Gpr120, but not Gpr40, which is mediated by FFA-induced calcium concentration response and GLP-1 secretion.	complete CACAO 10524
	GO:0046879	hormone secretion	PMID:15619630^[3]	ECO:0000314			P	Figure 4 c, d, displays effects of alpha-linolenic acids intubation on plasma GLP-1 and insulin concentrations in portal vein and IVC of mice.	complete CACAO 10525
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27853148^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0010827	regulation of glucose transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	F	Seeded From UniProt	complete
involved_in	GO:0046879	hormone secretion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN001202518	P	Seeded From UniProt	complete
enables	GO:0008527	taste receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN001202518 UniProtKB:R4GKJ9	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085410 MGI:MGI:2147577 PANTHER:PTN002384851 RGD:1308252 RGD:2787 RGD:2788	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085410 PANTHER:PTN002384851 UniProtKB:O43613 UniProtKB:O43614 UniProtKB:Q9TUP7	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN001202518	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN002384851 RGD:2788 RGD:708443 RGD:708445	F	Seeded From UniProt	complete
involved_in	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008527	P	Seeded From UniProt	complete
involved_in	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008527	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2AC31 ensembl:ENSRNOP00000032715	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0046879	hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	C	Seeded From UniProt	complete
involved_in	GO:0010827	regulation of glucose transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
enables	GO:0008527	taste receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Watson, SJ et al. (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol. Pharmacol. 81 631-42 PubMed GONUTS page
↑ Widmayer, P et al. (2012) Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients. Int J Obes (Lond) 36 1353-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hirasawa, A et al. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11 90-4 PubMed GONUTS page
↑ Quesada-López, T et al. (2016) The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun 7 13479 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22282525-1] Watson, SJ et al. (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol. Pharmacol. 81 631-42 PubMed GONUTS page

[PMID:22083550-2] Widmayer, P et al. (2012) Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients. Int J Obes (Lond) 36 1353-9 PubMed GONUTS page

[PMID:15619630-3] 3.0 ^3.1 ^3.2 Hirasawa, A et al. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11 90-4 PubMed GONUTS page

[PMID:27853148-4] Quesada-López, T et al. (2016) The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun 7 13479 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:FFAR4

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