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PMID:21901153
| Citation |
Martin, C, Passilly-Degrace, P, Gaillard, D, Merlin, JF, Chevrot, M and Besnard, P (2011) The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference. PLoS ONE 6:e24014 |
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| Abstract |
Recent studies in rodents and humans suggest that the chemoreception of long-chain fatty acids (LCFA) in oral cavity is involved in the spontaneous preference for fatty foods and might contribute to the obesity risk. CD36 and GPR120 are LCFA receptors identified in rodent taste bud cells. The fact that CD36 or GPR120 gene inactivation leads to a decrease in the preference for lipids raises the question of the respective role(s) played by these gustatory lipid-sensor candidates. |
| Links |
PubMed PMC3162022 Online version:10.1371/journal.pone.0024014 |
| Keywords |
Animals; Antigens, CD36/genetics; Antigens, CD36/metabolism; Blotting, Western; Circadian Rhythm; Dietary Fats/pharmacology; Food Preferences/drug effects; Food Preferences/physiology; Gene Expression/drug effects; Immunohistochemistry; Male; Mice; Mice, Knockout; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Taste Buds/drug effects; Taste Buds/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008289: lipid binding |
ECO:0000270: |
F |
GPR120 gene inactivation has led to a decrease in the preference for lipids. The different mRNA transcipts and gene expression were displayed in Figure 1 and 2 respectively. Figure 3 shows how the receptor is regulated by diet. |
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See also
References
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