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MOUSE:FFAR4
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ffar4 (synonyms: Gpr120, O3far1) | |
| Protein Name(s) | Free fatty acid receptor 4
G-protein coupled receptor 120 G-protein coupled receptor GT01 Omega-3 fatty acid receptor 1 | |
| External Links | ||
| UniProt | Q7TMA4 | |
| EMBL | AB115769 AY288424 BC053698 | |
| CCDS | CCDS29783.1 | |
| RefSeq | NP_861413.1 | |
| UniGene | Mm.35288 | |
| ProteinModelPortal | Q7TMA4 | |
| SMR | Q7TMA4 | |
| IntAct | Q7TMA4 | |
| BindingDB | Q7TMA4 | |
| ChEMBL | CHEMBL2052036 | |
| PhosphoSite | Q7TMA4 | |
| PRIDE | Q7TMA4 | |
| Ensembl | ENSMUST00000067098 | |
| GeneID | 107221 | |
| KEGG | mmu:107221 | |
| UCSC | uc008hjc.1 | |
| CTD | 338557 | |
| MGI | MGI:2147577 | |
| eggNOG | NOG241328 | |
| GeneTree | ENSGT00390000009371 | |
| HOVERGEN | HBG051775 | |
| InParanoid | Q7TMA4 | |
| KO | K08425 | |
| OMA | YSKILQI | |
| OrthoDB | EOG7PK900 | |
| PhylomeDB | Q7TMA4 | |
| TreeFam | TF336844 | |
| Reactome | REACT_198709 REACT_259776 | |
| NextBio | 358620 | |
| PRO | PR:Q7TMA4 | |
| Proteomes | UP000000589 | |
| Bgee | Q7TMA4 | |
| CleanEx | MM_GPR120 | |
| ExpressionAtlas | Q7TMA4 | |
| Genevestigator | Q7TMA4 | |
| GO | GO:0030139 GO:0016021 GO:0005886 GO:0005504 GO:0004930 GO:0008527 GO:0050912 GO:0007186 GO:0046879 GO:0043066 GO:0050710 GO:0050728 GO:0070374 GO:0010827 | |
| InterPro | IPR000276 IPR017452 | |
| Pfam | PF00001 | |
| PRINTS | PR00237 | |
| PROSITE | PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045444 |
fat cell differentiation |
ECO:0000315 |
P |
Figure 2 suggests that in GPR120 deficient mice there was increased adipogenesis (fat cell differentiation) resulting in obesity. |
complete | |||||
| GO:0008289 |
lipid binding |
ECO:0000314 |
F |
Injection of certain fatty acids into mice activate a signal transduction pathway through the GPR120 unsaturated fatty acid receptor. Unsaturated fatty acids act as nutritents in the body or act directly in the hypothalamus. Figure 1 shows the experimental procedures used. Figure 4 shows the signal transduction pathway for this receptor. Finally Figure 9 shows the pathway used by the hypothalamus. When the ligand binds, GPR120 activates a pathway that switches off inflammatory pathways that were found in the hypothalamus of obese rats. |
complete | |||||
| GO:0008289 |
lipid binding |
ECO:0000269 |
F |
Long chain fatty acids are the main activating component of lipids. GPR120, a long chain fatty acid receptor. It is found in taste buds as well as surrounding epithelial cells.It plays a role in human gut fatty acid perception. |
complete | |||||
| GO:0007165 |
signal transduction |
ECO:0000314 |
P |
The specific chemical structure of fatty acids have a particular effect on the GPR 120 receptor (Figure 2). |
complete | |||||
| GO:0008289 |
lipid binding |
ECO:0000270 |
F |
GPR120 gene inactivation has led to a decrease in the preference for lipids. The different mRNA transcipts and gene expression were displayed in Figure 1 and 2 respectively. Figure 3 shows how the receptor is regulated by diet. |
complete | |||||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045444 |
fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050710 |
negative regulation of cytokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010827 |
regulation of glucose transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008527 |
taste receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046879 |
hormone secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2147577 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008527 |
taste receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2147577 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0085410 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0085410 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2147577 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2147577 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046879 |
hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030139 |
endocytic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1308252 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050912 |
detection of chemical stimulus involved in sensory perception of taste |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008527 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050912 |
detection of chemical stimulus involved in sensory perception of taste |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008527 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q2AC31 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-MMU-444204 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ichimura, A et al. (2012) Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483 350-4 PubMed GONUTS page
- ↑ Cintra, DE et al. (2012) Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS ONE 7 e30571 PubMed GONUTS page
- ↑ Galindo, MM et al. (2012) G protein-coupled receptors in human fat taste perception. Chem. Senses 37 123-39 PubMed GONUTS page
- ↑ Holliday, ND et al. (2011) Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids. Front Endocrinol (Lausanne) 2 112 PubMed GONUTS page
- ↑ Martin, C et al. (2011) The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference. PLoS ONE 6 e24014 PubMed GONUTS page
- ↑ Quesada-López, T et al. (2016) The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun 7 13479 PubMed GONUTS page
- ↑ 7.0 7.1 Katsuma, S et al. (2005) Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. J. Biol. Chem. 280 19507-15 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Oh, DY et al. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142 687-98 PubMed GONUTS page
- ↑ Cartoni, C et al. (2010) Taste preference for fatty acids is mediated by GPR40 and GPR120. J. Neurosci. 30 8376-82 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Hirasawa, A et al. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11 90-4 PubMed GONUTS page
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