GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:22279596
| Citation |
Cintra, DE, Ropelle, ER, Moraes, JC, Pauli, JR, Morari, J, Souza, CT, Grimaldi, R, Stahl, M, Carvalheira, JB, Saad, MJ and Velloso, LA (2012) Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS ONE 7:e30571 |
|---|---|
| Abstract |
In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity. Pharmacological and gene-based approaches have proven efficient in restraining inflammation and correcting the obese phenotypes. However, the role of nutrients in the modulation of hypothalamic inflammation is unknown. |
| Links |
PubMed PMC3261210 Online version:10.1371/journal.pone.0030571 |
| Keywords |
Animals; Dietary Fats/administration & dosage; Dietary Fats/adverse effects; Dietary Fats, Unsaturated/administration & dosage; Eating/drug effects; Fatty Acids/blood; Fatty Acids/chemistry; Fatty Acids/metabolism; Fatty Acids, Omega-3/administration & dosage; Gene Expression/drug effects; Hypothalamus/drug effects; Hypothalamus/metabolism; Hypothalamus/pathology; Immunoblotting; Inflammation/blood; Inflammation/etiology; Inflammation/prevention & control; Insulin Resistance; Male; Mice; Nerve Tissue Proteins/genetics; Obesity/etiology; Obesity/physiopathology; Obesity/prevention & control; Plant Oils/administration & dosage; Pro-Opiomelanocortin/genetics; Rats; Rats, Wistar; Receptors, G-Protein-Coupled/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/drug effects; Weight Gain/drug effects |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008289: lipid binding |
ECO:0000314: |
F |
Injection of certain fatty acids into mice activate a signal transduction pathway through the GPR120 unsaturated fatty acid receptor. Unsaturated fatty acids act as nutritents in the body or act directly in the hypothalamus. Figure 1 shows the experimental procedures used. Figure 4 shows the signal transduction pathway for this receptor. Finally Figure 9 shows the pathway used by the hypothalamus. When the ligand binds, GPR120 activates a pathway that switches off inflammatory pathways that were found in the hypothalamus of obese rats. |
complete | ||||
| GO:0007186: G-protein coupled receptor signaling pathway |
ECO:0000314: |
P |
Figure 9 shows GPR120 forwarding the signal downstream as it binds to various fatty acids. |
complete | ||||
|
involved_in |
GO:0007186: G protein-coupled receptor signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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