RAT:FFAR4

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ffar4 (synonyms: Gpr120, O3far1)
Protein Name(s)	Free fatty acid receptor 4 G-protein coupled receptor 120 Omega-3 fatty acid receptor 1
External Links
UniProt	Q2AC31
EMBL	AB207868
RefSeq	NP_001040553.1
UniGene	Rn.82501
ProteinModelPortal	Q2AC31
STRING	10116.ENSRNOP00000032715
GuidetoPHARMACOLOGY	127
PhosphoSite	Q2AC31
PRIDE	Q2AC31
Ensembl	ENSRNOT00000034563
GeneID	294075
KEGG	rno:294075
UCSC	RGD:1308252
CTD	338557
RGD	1308252
eggNOG	NOG241328
GeneTree	ENSGT00390000009371
HOVERGEN	HBG051775
InParanoid	Q2AC31
KO	K08425
OMA	YSKILQI
OrthoDB	EOG7PK900
PhylomeDB	Q2AC31
TreeFam	TF336844
Reactome	REACT_196384 REACT_246486
NextBio	637527
PRO	PR:Q2AC31
Proteomes	UP000002494
Genevestigator	Q2AC31
GO	GO:0030139 GO:0016021 GO:0005886 GO:0005504 GO:0008527 GO:0046879 GO:0043066 GO:0050710 GO:0050728 GO:0070374 GO:0010827
InterPro	IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR00237
PROSITE	PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0007186	G-protein coupled receptor signaling pathway	PMID:22279596^[1]	ECO:0000314			P	Figure 9 shows GPR120 forwarding the signal downstream as it binds to various fatty acids.	complete CACAO 6624
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27853148^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:22279596^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
involved_in	GO:0010827	regulation of glucose transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7TMA4	F	Seeded From UniProt	complete
involved_in	GO:0046879	hormone secretion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN001202518	P	Seeded From UniProt	complete
enables	GO:0008527	taste receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN001202518 UniProtKB:R4GKJ9	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085410 MGI:MGI:2147577 PANTHER:PTN002384851 RGD:1308252 RGD:2787 RGD:2788	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0085410 PANTHER:PTN002384851 UniProtKB:O43613 UniProtKB:O43614 UniProtKB:Q9TUP7	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN001202518	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2147577 PANTHER:PTN002384851 RGD:2788 RGD:708443 RGD:708445	F	Seeded From UniProt	complete
involved_in	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008527	P	Seeded From UniProt	complete
involved_in	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008527	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0046879	hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	C	Seeded From UniProt	complete
involved_in	GO:0010827	regulation of glucose transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
enables	GO:0008527	taste receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMA4 ensembl:ENSMUSP00000063660	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Cintra, DE et al. (2012) Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS ONE 7 e30571 PubMed GONUTS page
↑ Quesada-López, T et al. (2016) The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun 7 13479 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22279596-1] 1.0 ^1.1 Cintra, DE et al. (2012) Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS ONE 7 e30571 PubMed GONUTS page

[PMID:27853148-2] Quesada-López, T et al. (2016) The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun 7 13479 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:FFAR4

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