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Category:Team Racer X

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorTITDI:KA156Mcravens, Team Racer X2013-02-10 16:35:31 CSTGO:0044477 envenomation resulting in negative regulation of platelet aggregation in other organism (P)PMID:21322750ECO:0000314 direct assay evidence used in manual assertion

Fig 2

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updatedbyinstructorBOTJA:VM3BMcravens, Team Racer X2013-02-10 16:03:12 CSTGO:0035893 negative regulation of platelet aggregation in other organism (P)PMID:15665869ECO:0000314 direct assay evidence used in manual assertion

A higher percentage of platelets are activated when exposed to botrocetin than when not (Figure 5). This chemical introduced by Gaboon Vipers causes hemorrhaging.

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updatedbyinstructorCALRH:SLYAMcravens, Team Racer X2013-02-10 15:41:06 CSTGO:0060300 regulation of cytokine activity (P)PMID:20738764ECO:0000314 direct assay evidence used in manual assertion

Results obtained from ELISA. The positive correlation between aggretin introduction and cytokine release by phagocytes is demonstrated in Fig 3.

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unacceptableMOUSE:FFAR4Sanwar, Team Racer X2013-02-10 15:26:25 CSTGO:0008289 lipid binding (F)PMID:21901153ECO:0000270 expression pattern evidence used in manual assertion

GPR120 gene inactivation has led to a decrease in the preference for lipids. The different mRNA transcipts and gene expression were displayed in Figure 1 and 2 respectively. Figure 3 shows how the receptor is regulated by diet.

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unacceptableMOUSE:FFAR4Sanwar, Team Racer X2013-02-10 15:11:29 CSTGO:0007165 signal transduction (P)PMID:22649399ECO:0000314 direct assay evidence used in manual assertion

The specific chemical structure of fatty acids have a particular effect on the GPR 120 receptor (Figure 2).

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unacceptableMOUSE:FFAR4Sanwar, Team Racer X2013-02-10 14:53:52 CSTGO:0008289 lipid binding (F)PMID:21868624ECO:0000269 experimental evidence used in manual assertion

Long chain fatty acids are the main activating component of lipids. GPR120, a long chain fatty acid receptor. It is found in taste buds as well as surrounding epithelial cells.It plays a role in human gut fatty acid perception.

challenge
unacceptableHUMAN:FFAR4Sanwar, Team Racer X2013-02-10 14:03:40 CSTGO:0007186 G-protein coupled receptor signaling pathway (P)PMID:22083550ECO:0000314 direct assay evidence used in manual assertion

GPR120 acts as a medium and a long-chain fatty acid receptor. The GPR120 band was stronger in morbidly obese people (Figure 2). This may be linked to higher mRNA levels in these persons (Figure 3).

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unacceptableMOUSE:FFAR4Sanwar, Team Racer X2013-02-10 12:51:47 CSTGO:0008289 lipid binding (F)PMID:22279596ECO:0000314 direct assay evidence used in manual assertion

Injection of certain fatty acids into mice activate a signal transduction pathway through the GPR120 unsaturated fatty acid receptor. Unsaturated fatty acids act as nutritents in the body or act directly in the hypothalamus. Figure 1 shows the experimental procedures used. Figure 4 shows the signal transduction pathway for this receptor. Finally Figure 9 shows the pathway used by the hypothalamus. When the ligand binds, GPR120 activates a pathway that switches off inflammatory pathways that were found in the hypothalamus of obese rats.

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requireschangesHUMAN:FFAR4Sanwar, Team Racer X2013-02-10 10:59:23 CSTGO:0004930 G-protein coupled receptor activity (F)PMID:22282525ECO:0000021 physical interaction evidence

GPR120 is a long chain fatty acid receptor that stimulates hormone release. Calcium mobilization and dynamic mass redistribution (DMR) were used to test receptor ability. Figure 1 showed that amino acid sequenced structure of GPR120. Figures 2 &3 showed the response of the receptor to calcium mobilization while 4 & 5 showed the responses of DMR. The activation of this receptor stimulated calcium mobilization changes as well as DMR through a specific signaling. pathway.

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Pages in category "Team Racer X"

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