Status | Page | User | Date/Time | GO Term (Aspect) | Reference | Evidence | Notes | Links |
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updatedbyinstructor | TITDI:KA156 | Mcravens, Team Racer X | 2013-02-10 16:35:31 CST | GO:0044477 envenomation resulting in negative regulation of platelet aggregation in other organism (P) | PMID:21322750 | ECO:0000314 direct assay evidence used in manual assertion | | challenge |
updatedbyinstructor | BOTJA:VM3B | Mcravens, Team Racer X | 2013-02-10 16:03:12 CST | GO:0035893 negative regulation of platelet aggregation in other organism (P) | PMID:15665869 | ECO:0000314 direct assay evidence used in manual assertion | A higher percentage of platelets are activated when exposed to botrocetin than when not (Figure 5). This chemical introduced by Gaboon Vipers causes hemorrhaging.
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updatedbyinstructor | CALRH:SLYA | Mcravens, Team Racer X | 2013-02-10 15:41:06 CST | GO:0060300 regulation of cytokine activity (P) | PMID:20738764 | ECO:0000314 direct assay evidence used in manual assertion | Results obtained from ELISA. The positive correlation between aggretin introduction and cytokine release by phagocytes is demonstrated in Fig 3.
| challenge |
unacceptable | MOUSE:FFAR4 | Sanwar, Team Racer X | 2013-02-10 15:26:25 CST | GO:0008289 lipid binding (F) | PMID:21901153 | ECO:0000270 expression pattern evidence used in manual assertion | GPR120 gene inactivation has led to a decrease in the preference for lipids. The different mRNA transcipts and gene expression were displayed in Figure 1 and 2 respectively. Figure 3 shows how the receptor is regulated by diet.
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unacceptable | MOUSE:FFAR4 | Sanwar, Team Racer X | 2013-02-10 15:11:29 CST | GO:0007165 signal transduction (P) | PMID:22649399 | ECO:0000314 direct assay evidence used in manual assertion | The specific chemical structure of fatty acids have a particular effect on the GPR 120 receptor (Figure 2).
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unacceptable | MOUSE:FFAR4 | Sanwar, Team Racer X | 2013-02-10 14:53:52 CST | GO:0008289 lipid binding (F) | PMID:21868624 | ECO:0000269 experimental evidence used in manual assertion | Long chain fatty acids are the main activating component of lipids. GPR120, a long chain fatty acid receptor. It is found in taste buds as well as surrounding epithelial cells.It plays a role in human gut fatty acid perception.
| challenge |
unacceptable | HUMAN:FFAR4 | Sanwar, Team Racer X | 2013-02-10 14:03:40 CST | GO:0007186 G-protein coupled receptor signaling pathway (P) | PMID:22083550 | ECO:0000314 direct assay evidence used in manual assertion | GPR120 acts as a medium and a long-chain fatty acid receptor. The GPR120 band was stronger in morbidly obese people (Figure 2). This may be linked to higher mRNA levels in these persons (Figure 3).
| challenge |
unacceptable | MOUSE:FFAR4 | Sanwar, Team Racer X | 2013-02-10 12:51:47 CST | GO:0008289 lipid binding (F) | PMID:22279596 | ECO:0000314 direct assay evidence used in manual assertion | Injection of certain fatty acids into mice activate a signal transduction pathway through the GPR120 unsaturated fatty acid receptor. Unsaturated fatty acids act as nutritents in the body or act directly in the hypothalamus. Figure 1 shows the experimental procedures used. Figure 4 shows the signal transduction pathway for this receptor. Finally Figure 9 shows the pathway used by the hypothalamus. When the ligand binds, GPR120 activates a pathway that switches off inflammatory pathways that were found in the hypothalamus of obese rats.
| challenge |
requireschanges | HUMAN:FFAR4 | Sanwar, Team Racer X | 2013-02-10 10:59:23 CST | GO:0004930 G-protein coupled receptor activity (F) | PMID:22282525 | ECO:0000021 physical interaction evidence | GPR120 is a long chain fatty acid receptor that stimulates hormone release. Calcium mobilization and dynamic mass redistribution (DMR) were used to test receptor ability. Figure 1 showed that amino acid sequenced structure of GPR120. Figures 2 &3 showed the response of the receptor to calcium mobilization while 4 & 5 showed the responses of DMR. The activation of this receptor stimulated calcium mobilization changes as well as DMR through a specific signaling. pathway.
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