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PMID:20738764
| Citation |
Chang, CH, Chung, CH, Hsu, CC, Huang, TY and Huang, TF (2010) A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation. J. Thromb. Haemost. 8:2563-70 |
|---|---|
| Abstract |
Macrophages are major immune cells and play an important role in modulating homeostasis and the immune defense mechanism. In inflammatory responses to the infection of pathogens, macrophages are activated, producing various inflammatory mediators. Snake venom C-type lectin proteins (snaclecs) have diverse targets, including platelet GPVI, GPIb, integrin α2β1 or CLEC-2 expressed in platelets, endothelial cells or myeloid cells. |
| Links |
PubMed Online version:10.1111/j.1538-7836.2010.04045.x |
| Keywords |
Animals; Cytokines/metabolism; Inflammation; Interleukin-6/metabolism; Lectins, C-Type/chemistry; Lectins, C-Type/metabolism; MAP Kinase Signaling System; Macrophages/cytology; Mice; Mice, Inbred ICR; Monocytes/cytology; NF-kappa B/metabolism; Phagocytes/cytology; Snake Venoms; Tumor Necrosis Factor-alpha/metabolism; Viper Venoms/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0060300: regulation of cytokine activity |
ECO:0000314: |
P |
Results obtained from ELISA. The positive correlation between aggretin introduction and cytokine release by phagocytes is demonstrated in Fig 3. |
complete | ||||
|
involved_in |
GO:0060300: regulation of cytokine activity |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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