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HUMAN:TRBM

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) THBD (synonyms: THRM)
Protein Name(s) Thrombomodulin

TM Fetomodulin

External Links
UniProt P07204
EMBL X05495
M16552
J02973
D00210
AF495471
AL049651
BC035602
BC053357
CCDS CCDS13148.1
PIR A41442
RefSeq NP_000352.1
UniGene Hs.2030
PDB 1ADX
1DQB
1DX5
1EGT
1FGD
1FGE
1HLT
1TMR
1ZAQ
2ADX
3GIS
PDBsum 1ADX
1DQB
1DX5
1EGT
1FGD
1FGE
1HLT
1TMR
1ZAQ
2ADX
3GIS
ProteinModelPortal P07204
SMR P07204
BioGrid 112914
IntAct P07204
STRING 9606.ENSP00000366307
DrugBank DB00055
DB01050
PhosphoSite P07204
UniCarbKB P07204
DMDM 136170
MaxQB P07204
PaxDb P07204
PRIDE P07204
DNASU 7056
Ensembl ENST00000377103
GeneID 7056
KEGG hsa:7056
UCSC uc002wss.3
CTD 7056
GeneCards GC20M023026
GeneReviews THBD
H-InvDB HIX0174703
HGNC HGNC:11784
HPA CAB002425
HPA002982
MIM 188040
612926
614486
neXtProt NX_P07204
Orphanet 217023
3324
PharmGKB PA36496
eggNOG NOG147686
GeneTree ENSGT00770000120465
HOGENOM HOG000114624
HOVERGEN HBG000291
InParanoid P07204
KO K03907
OMA LCGPLCV
OrthoDB EOG70ZZMW
PhylomeDB P07204
TreeFam TF330714
Reactome REACT_12051
REACT_1439
ChiTaRS THBD
EvolutionaryTrace P07204
GeneWiki Thrombomodulin
GenomeRNAi 7056
NextBio 27593
PRO PR:P07204
Proteomes UP000005640
Bgee P07204
CleanEx HS_THBD
Genevestigator P07204
GO GO:0009986
GO:0005615
GO:0005887
GO:0005886
GO:0005509
GO:0030246
GO:0004872
GO:0004888
GO:0007596
GO:0007565
GO:0050900
GO:0030195
GO:0051918
GO:0010544
GO:0051591
GO:0032496
GO:0010165
Gene3D 3.10.100.10
InterPro IPR001304
IPR016186
IPR016187
IPR016316
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR009030
IPR001491
IPR015149
Pfam PF07645
PF09064
PIRSF PIRSF001775
PRINTS PR00907
SMART SM00034
SM00181
SM00179
SUPFAM SSF56436
SSF57184
PROSITE PS00010
PS50041
PS01186
PS50026
PS01187

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0009986

cell surface

PMID:17379830[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0030195

negative regulation of blood coagulation

PMID:23383040[2]

ECO:0000269

P

Figure 1: MIF, sTM and PC concentrations are increased in plasma of patients with DHF cited from PMID:23383040[2]. Thrombomodulin induces the activation of Protein C which is not very helpful for a person infected with DHF. It can be very harmful.

complete
CACAO 6510

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

P

Seeded From UniProt

complete

part_of

GO:0016327

apicolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

C

Seeded From UniProt

complete

involved_in

GO:0010165

response to X-ray

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

C

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35370
ensembl:ENSRNOP00000006200

C

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P15306
ensembl:ENSMUSP00000096877

P

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015149
InterPro:IPR016316

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016316

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015149

C

Seeded From UniProt

complete

involved_in

GO:0030195

negative regulation of blood coagulation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016316

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:9252393[3]
Reactome:R-HSA-140875

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:2822087[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:10336638[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:2822087[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051918

negative regulation of fibrinolysis

PMID:17379830[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030195

negative regulation of blood coagulation

PMID:17379830[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010544

negative regulation of platelet activation

PMID:17379830[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

Reactome:R-HSA-202733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-141046
Reactome:R-HSA-141040

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0094

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0356

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Bouton, MC et al. (2007) Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Circ. Res. 100 1174-81 PubMed GONUTS page
  2. 2.0 2.1 Yeh, TM et al. (2013) Dengue virus enhances thrombomodulin and ICAM-1 expression through the macrophage migration inhibitory factor induction of the MAPK and PI3K signaling pathways. PLoS ONE 8 e55018 PubMed GONUTS page
  3. van 't Veer, C et al. (1997) Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN. J. Biol. Chem. 272 20721-9 PubMed GONUTS page
  4. 4.0 4.1 Wen, DZ et al. (1987) Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry 26 4350-7 PubMed GONUTS page
  5. Light, DR et al. (1999) The interaction of thrombomodulin with Ca2+. Eur. J. Biochem. 262 522-33 PubMed GONUTS page