GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:TRBM
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | THBD (synonyms: THRM) | |
Protein Name(s) | Thrombomodulin
TM Fetomodulin | |
External Links | ||
UniProt | P07204 | |
EMBL | X05495 M16552 J02973 D00210 AF495471 AL049651 BC035602 BC053357 | |
CCDS | CCDS13148.1 | |
PIR | A41442 | |
RefSeq | NP_000352.1 | |
UniGene | Hs.2030 | |
PDB | 1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS | |
PDBsum | 1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS | |
ProteinModelPortal | P07204 | |
SMR | P07204 | |
BioGrid | 112914 | |
IntAct | P07204 | |
STRING | 9606.ENSP00000366307 | |
DrugBank | DB00055 DB01050 | |
PhosphoSite | P07204 | |
UniCarbKB | P07204 | |
DMDM | 136170 | |
MaxQB | P07204 | |
PaxDb | P07204 | |
PRIDE | P07204 | |
DNASU | 7056 | |
Ensembl | ENST00000377103 | |
GeneID | 7056 | |
KEGG | hsa:7056 | |
UCSC | uc002wss.3 | |
CTD | 7056 | |
GeneCards | GC20M023026 | |
GeneReviews | THBD | |
H-InvDB | HIX0174703 | |
HGNC | HGNC:11784 | |
HPA | CAB002425 HPA002982 | |
MIM | 188040 612926 614486 | |
neXtProt | NX_P07204 | |
Orphanet | 217023 3324 | |
PharmGKB | PA36496 | |
eggNOG | NOG147686 | |
GeneTree | ENSGT00770000120465 | |
HOGENOM | HOG000114624 | |
HOVERGEN | HBG000291 | |
InParanoid | P07204 | |
KO | K03907 | |
OMA | LCGPLCV | |
OrthoDB | EOG70ZZMW | |
PhylomeDB | P07204 | |
TreeFam | TF330714 | |
Reactome | REACT_12051 REACT_1439 | |
ChiTaRS | THBD | |
EvolutionaryTrace | P07204 | |
GeneWiki | Thrombomodulin | |
GenomeRNAi | 7056 | |
NextBio | 27593 | |
PRO | PR:P07204 | |
Proteomes | UP000005640 | |
Bgee | P07204 | |
CleanEx | HS_THBD | |
Genevestigator | P07204 | |
GO | GO:0009986 GO:0005615 GO:0005887 GO:0005886 GO:0005509 GO:0030246 GO:0004872 GO:0004888 GO:0007596 GO:0007565 GO:0050900 GO:0030195 GO:0051918 GO:0010544 GO:0051591 GO:0032496 GO:0010165 | |
Gene3D | 3.10.100.10 | |
InterPro | IPR001304 IPR016186 IPR016187 IPR016316 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR009030 IPR001491 IPR015149 | |
Pfam | PF07645 PF09064 | |
PIRSF | PIRSF001775 | |
PRINTS | PR00907 | |
SMART | SM00034 SM00181 SM00179 | |
SUPFAM | SSF56436 SSF57184 | |
PROSITE | PS00010 PS50041 PS01186 PS50026 PS01187 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
GO:0030195 |
negative regulation of blood coagulation |
ECO:0000269 |
P |
Figure 1: MIF, sTM and PC concentrations are increased in plasma of patients with DHF cited from PMID:23383040[2]. Thrombomodulin induces the activation of Protein C which is not very helpful for a person infected with DHF. It can be very harmful. |
complete | |||||
involved_in |
GO:0051591 |
response to cAMP |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016327 |
apicolateral plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010165 |
response to X-ray |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005774 |
vacuolar membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O35370 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P15306 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030195 |
negative regulation of blood coagulation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007596 |
blood coagulation |
PMID:9252393[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005509 |
calcium ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051918 |
negative regulation of fibrinolysis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030195 |
negative regulation of blood coagulation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010544 |
negative regulation of platelet activation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050900 |
leukocyte migration |
Reactome:R-HSA-202733 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-141046 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007599 |
hemostasis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Bouton, MC et al. (2007) Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Circ. Res. 100 1174-81 PubMed GONUTS page
- ↑ 2.0 2.1 Yeh, TM et al. (2013) Dengue virus enhances thrombomodulin and ICAM-1 expression through the macrophage migration inhibitory factor induction of the MAPK and PI3K signaling pathways. PLoS ONE 8 e55018 PubMed GONUTS page
- ↑ van 't Veer, C et al. (1997) Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN. J. Biol. Chem. 272 20721-9 PubMed GONUTS page
- ↑ 4.0 4.1 Wen, DZ et al. (1987) Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry 26 4350-7 PubMed GONUTS page
- ↑ Light, DR et al. (1999) The interaction of thrombomodulin with Ca2+. Eur. J. Biochem. 262 522-33 PubMed GONUTS page