User:JmicG

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	PIG:F1RSS8	2011-09-19 19:51:44 CDT	GO:0005886 plasma membrane (C)	PMID:21251292	ECO:0000314 direct assay evidence used in manual assertion	In figure 7, the authors demonstrate the presence of porcine RXFP2 on the plasma membrane of porcine oocytes and embryos using immunofluoresence.	challenge
acceptable	PIG:RELX	2011-09-24 21:39:08 CDT	GO:0001832 blastocyst growth (P)	PMID:21272344	ECO:0000314 direct assay evidence used in manual assertion	In table 4, the authors demonstrate that the addition of porcine relaxin during in vitro culture increases the number of cells in porcine blastocysts.	challenge
acceptable	PIG:RELX	2011-09-19 20:15:57 CDT	GO:0001556 oocyte maturation (P)	PMID:21272344	ECO:0000314 direct assay evidence used in manual assertion	In table 2, the authors demonstrate that the addition of porcine relaxin during in vitro maturation reduced the the proportion of porcine oocytes that retained a germinal vesicle and increased the proportions of porcine oocytes that reach metaphase 2 (MII), both of which are characteristic of oocyte maturation.	challenge
unacceptable	PIG:RELX	2011-09-23 13:57:54 CDT	GO:0034105 positive regulation of tissue remodeling (P)	PMID:8319559	ECO:0000314 direct assay evidence used in manual assertion	In figure 2, the authors show that porcine relaxin therapy in ovariectomized gilts restored collagen organization in the cervix during pregnancy.	challenge
acceptable	PIG:RELX	2011-09-20 18:33:12 CDT	GO:0030317 sperm motility (P)	PMID:16926527	ECO:0000314 direct assay evidence used in manual assertion	In figure 1, the authors demonstrate that the addition of porcine relaxin increases the motility of boar spermatozoa.	challenge
acceptable	PIG:RELX	2011-09-21 16:47:52 CDT	GO:0046326 positive regulation of glucose import (P)	PMID:16926527	ECO:0000314 direct assay evidence used in manual assertion	In figure 2, the authors demonstrate that the addition of porcine relaxin increases the glucose import in boar spermatozoa.	challenge
requireschanges	HUMAN:RXFP1	2011-09-20 20:36:17 CDT	GO:0030819 positive regulation of cAMP biosynthetic process (P)	PMID:16569707	ECO:0000314 direct assay evidence used in manual assertion	In figure 1, the authors demonstrate that human RXFP1 has a positive influence on cAMP production in the presence of its ligand.	challenge
acceptable	HUMAN:REL2	2011-09-22 11:03:07 CDT	GO:0010628 positive regulation of gene expression (P)	PMID:11459784	ECO:0000314 direct assay evidence used in manual assertion	In figure 1, the authors demonstrate that the addition of human relaxin stimulates the expression of pro-MMP-1 at both the mRNA and protein level.	challenge
acceptable	PIG:RELX	2011-09-23 14:04:32 CDT	GO:2000344 positive regulation of acrosome reaction (P)	PMID:16926527	ECO:0000314 direct assay evidence used in manual assertion	In figure 1, the authors demonstrate that the addition of porcine relaxin increased the proportion of live boar spermatozoa that had undergone the acrosome reaction.	challenge
acceptable	HUMAN:REL2	2011-09-24 22:46:44 CDT	GO:0045766 positive regulation of angiogenesis (P)	PMID:16049981	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 8, the authors demonstrate that tumors, comprised of human prostate tumor cells, had greater microvessel density when made to overexpress human relaxin.	challenge
acceptable	RAT:REL1	2011-09-24 22:26:01 CDT	GO:0042127 regulation of cell proliferation (P)	PMID:15498891	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 4, the authors demonstrate that the neutralization of endogenous relaxin during late pregnancy has a negative effect on cervical epithelial and stromal cell proliferation.	challenge
acceptable	RAT:REL1	2011-09-24 22:25:18 CDT	GO:0043066 negative regulation of apoptotic process (P)	PMID:15498891	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 6, the authors demonstrate that the neutralization of endogenous relaxin during late pregnancy increases apoptosis in cervical epithelial and stromal tissue.	challenge
acceptable	HUMAN:REL2	2011-09-24 22:51:24 CDT	GO:0048552 regulation of metalloenzyme activity (P)	PMID:16049981	ECO:0000314 direct assay evidence used in manual assertion	In figure 6A, the authors demonstrate that the addition of human relaxin increases the activity of matrix metalloproteinase activity in human prostate tumor cells.	challenge
acceptable	PIG:RELX	2011-09-24 23:14:29 CDT	GO:0050679 positive regulation of epithelial cell proliferation (P)	PMID:16956745	ECO:0000314 direct assay evidence used in manual assertion	In figure 6, the authors demonstrate that porcine relaxin increases the proportion of cells that are positive for proliferating cell nuclear antigen, indicating cell proliferation.	challenge
acceptable	MOUSE:INSL3	2011-09-25 15:18:10 CDT	GO:2000018 regulation of male gonad development (P)	PMID:10319319	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 3 A&C, the authors demonstrate that homozygous mutant male mice, deficient in INSL3, exhibited bilateral cryptorchid testes located high in the abdomen.	challenge
acceptable	MOUSE:REL1	2011-09-25 17:21:34 CDT	GO:0007283 spermatogenesis (P)	PMID:12861045	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 2 E,F,G &H, the authors demonstrate that there is a reduction in mature spermatozoa formation in seminiferous tubules of homozygous relaxin knockout mice.	challenge
acceptable	MOUSE:REL1	2011-09-25 17:31:12 CDT	GO:0042981 regulation of apoptosis (P)	PMID:12861045	ECO:0000315 mutant phenotype evidence used in manual assertion	In table 2, the authors demonstrate that homozygous relaxin knockout mice had more Bax and caspase-9 positive cells in the testis.	challenge
acceptable	MOUSE:REL1	2011-09-25 17:57:05 CDT	GO:0060443 mammary gland morphogenesis (P)	PMID:9886856	ECO:0000315 mutant phenotype evidence used in manual assertion	In table 1, the authors demonstrate that homozygous relaxin knockout mice displayed altered mammary gland morphogenesis.	challenge
acceptable	MOUSE:REL1	2011-09-25 17:57:05 CDT	GO:0060618 nipple development (P)	PMID:9886856	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 6, the authors demonstrate that homozygous relaxin knockout mice displayed abnormal nipple development after parturition.	challenge

acceptable:17
unacceptable:1
requires_changes:1
flagged:0

Annotations challenged by JmicG

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
acceptable	JmicG, Team Mighty Morphin GO Annotators	MOUSE:REL1	GO:0060443 - mammary gland morphogenesis (P)	PMID:9886856	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3
acceptable	JmicG, Team Mighty Morphin GO Annotators	MOUSE:REL1	GO:0060618 - nipple development (P)	PMID:9886856	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4
acceptable	JmicG, Team Mighty Morphin GO Annotators	RAT:REL1	GO:0043066 - negative regulation of apoptotic process (P)	PMID:15498891	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2
acceptable	JmicG, Team Mighty Morphin GO Annotators	HUMAN:REL2	GO:0045766 - positive regulation of angiogenesis (P)	PMID:16049981	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2
acceptable	JmicG, Team Mighty Morphin GO Annotators	HUMAN:REL2	GO:0048552 - regulation of metalloenzyme activity (P)	PMID:16049981	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2

0 annotations fixed by JmicG