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GO:0008284positive regulation of cell proliferationPMID:16956745IDA: Inferred from Direct Assay P
This annotation made on page: PIG:RELX
By: JmicG (group Team Mighty Morphin GO Annotators) on 2011-09-24 23:14:29 CDT.

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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
Mkline2012-03-26 10:59:55 CDTYou need to be an instructor to view these notes.Acceptable
Bmcintosh2011-11-23 15:23:15 CST

The two cell types that are being studied are epithelial cells, so perhaps selecting: GO:0050673 epithelial cell proliferation or GO:0050679 positive regulation of epithelial cell proliferation may be closer to the mark.

In Fig 6 the authors also use an inhibitor (the ICI is an estrogen receptor antagonist). ICI+estrogen or ICI+Relaxin decreases the amount of cell proliferation, indicating that both estrogen and relaxin act via estrogen signaling. To capture this I would also add: Pig relaxin IMP GO:0033148 positive regulation of estrogen receptor signaling pathway (this will capture that there is cross talk between relaxin & estrogen in this system)

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Bmcintosh2011-10-18 15:34:40 CDTYou need to be an instructor to view these notes.Flagged