GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
|GO:0008284||positive regulation of cell proliferation||PMID:16956745||IDA: Inferred from Direct Assay||P|
|This annotation made on page: PIG:RELX|
By: JmicG (group Team Mighty Morphin GO Annotators) on 2011-09-24 23:14:29 CDT.
|Team Mighty Morphin GO Annotators||5|
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|Entry Type||Challenging User,Group||Time/Date||Challenge Reason||Points/Assessment|
|Mkline||2012-03-26 10:59:55 CDT||You need to be an instructor to view these notes.||Acceptable|
|Bmcintosh||2011-11-23 15:23:15 CST|
The two cell types that are being studied are epithelial cells, so perhaps selecting: GO:0050673 epithelial cell proliferation or GO:0050679 positive regulation of epithelial cell proliferation may be closer to the mark.
In Fig 6 the authors also use an inhibitor (the ICI is an estrogen receptor antagonist). ICI+estrogen or ICI+Relaxin decreases the amount of cell proliferation, indicating that both estrogen and relaxin act via estrogen signaling. To capture this I would also add: Pig relaxin IMP GO:0033148 positive regulation of estrogen receptor signaling pathway (this will capture that there is cross talk between relaxin & estrogen in this system)
|Bmcintosh||2011-10-18 15:34:40 CDT||You need to be an instructor to view these notes.||Flagged|