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PIG:RELX

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Species (Taxon ID) Sus scrofa (Pig). (9823)
Gene Name(s) RLN
Protein Name(s) Prorelaxin

Relaxin B chain Relaxin A chain

External Links
UniProt P01348
EMBL K01088
J02792
PIR A90934
RefSeq NP_999037.1
UniGene Ssc.82485
PDB 1RLX
2RLX
3RLX
4RLX
PDBsum 1RLX
2RLX
3RLX
4RLX
MINT MINT-231177
PRIDE P01348
GeneID 396891
KEGG ssc:396891
CTD 100329416
eggNOG NOG40989
HOGENOM HOG000236342
HOVERGEN HBG003234
InParanoid P01348
KO K05255
Proteomes UP000008227
GO GO:0005576
InterPro IPR016179
IPR022353
IPR022421
Pfam PF00049
PRINTS PR02004
SMART SM00078
SUPFAM SSF56994
PROSITE PS00262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001832

blastocyst growth

PMID:21272344[1]

ECO:0000314

P

In table 4, the authors demonstrate that the addition of porcine relaxin during in vitro culture increases the number of cells in porcine blastocysts.

complete
CACAO 1951

GO:0001556

oocyte maturation

PMID:21272344[1]

ECO:0000314

P

In table 2, the authors demonstrate that the addition of porcine relaxin during in vitro maturation reduced the the proportion of porcine oocytes that retained a germinal vesicle and increased the proportions of porcine oocytes that reach metaphase 2 (MII), both of which are characteristic of oocyte maturation.

complete
CACAO 1952

GO:0034105

positive regulation of tissue remodeling

PMID:8319559[2]

ECO:0000314

P

In figure 2, the authors show that porcine relaxin therapy in ovariectomized gilts restored collagen organization in the cervix during pregnancy.

complete
CACAO 1953

GO:0030317

sperm motility

PMID:16926527[3]

ECO:0000314

P

In figure 1, the authors demonstrate that the addition of porcine relaxin increases the motility of boar spermatozoa.

complete
CACAO 1958

GO:0046326

positive regulation of glucose import

PMID:16926527[3]

ECO:0000314

P

In figure 2, the authors demonstrate that the addition of porcine relaxin increases the glucose import in boar spermatozoa.

complete
CACAO 1959

GO:2000344

positive regulation of acrosome reaction

PMID:16926527[3]

ECO:0000314

P

In figure 1, the authors demonstrate that the addition of porcine relaxin increased the proportion of live boar spermatozoa that had undergone the acrosome reaction.

complete
CACAO 2004

GO:0050679

positive regulation of epithelial cell proliferation

PMID:16956745[4]

ECO:0000314

P

In figure 6, the authors demonstrate that porcine relaxin increases the proportion of cells that are positive for proliferating cell nuclear antigen, indicating cell proliferation.

complete
CACAO 2051

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

PMID:16956745[4]

ECO:0000315

P

Fig. 6

complete

involved_in

GO:2000344

positive regulation of acrosome reaction

PMID:16926527[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001556

oocyte maturation

PMID:21272344[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001832

blastocyst growth

PMID:21272344[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030317

flagellated sperm motility

PMID:16926527[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

PMID:16926527[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

PMID:16956745[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016179
InterPro:IPR022421

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016179
InterPro:IPR022421

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Feugang, JM et al. (2011) In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos. Reprod. Biol. Endocrinol. 9 15 PubMed GONUTS page
  2. Winn, RJ et al. (1993) Hormonal control of the cervix in pregnant gilts. IV. Relaxin promotes changes in the histological characteristics of the cervix that are associated with cervical softening during late pregnancy in gilts. Endocrinology 133 121-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Miah, AG et al. (2006) Effect of relaxin on acrosome reaction and utilization of glucose in boar spermatozoa. J. Reprod. Dev. 52 773-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 Masters, RA et al. (2007) Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin. Domest. Anim. Endocrinol. 33 335-46 PubMed GONUTS page