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Category:Team Mighty Morphin GO Annotators

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableMOUSE:REL1JmicG, Team Mighty Morphin GO Annotators2011-09-25 17:57:05 CDTGO:0060443 mammary gland morphogenesis (P)PMID:9886856ECO:0000315 mutant phenotype evidence used in manual assertion

In table 1, the authors demonstrate that homozygous relaxin knockout mice displayed altered mammary gland morphogenesis.

challenge
acceptableMOUSE:REL1JmicG, Team Mighty Morphin GO Annotators2011-09-25 17:57:05 CDTGO:0060618 nipple development (P)PMID:9886856ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 6, the authors demonstrate that homozygous relaxin knockout mice displayed abnormal nipple development after parturition.

challenge
acceptableMOUSE:REL1JmicG, Team Mighty Morphin GO Annotators2011-09-25 17:31:12 CDTGO:0042981 regulation of apoptosis (P)PMID:12861045ECO:0000315 mutant phenotype evidence used in manual assertion

In table 2, the authors demonstrate that homozygous relaxin knockout mice had more Bax and caspase-9 positive cells in the testis.

challenge
acceptableMOUSE:REL1JmicG, Team Mighty Morphin GO Annotators2011-09-25 17:21:34 CDTGO:0007283 spermatogenesis (P)PMID:12861045ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 2 E,F,G &H, the authors demonstrate that there is a reduction in mature spermatozoa formation in seminiferous tubules of homozygous relaxin knockout mice.

challenge
acceptableMOUSE:INSL3JmicG, Team Mighty Morphin GO Annotators2011-09-25 15:18:10 CDTGO:2000018 regulation of male gonad development (P)PMID:10319319ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 3 A&C, the authors demonstrate that homozygous mutant male mice, deficient in INSL3, exhibited bilateral cryptorchid testes located high in the abdomen.

challenge
acceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-24 23:14:29 CDTGO:0050679 positive regulation of epithelial cell proliferation (P)PMID:16956745ECO:0000314 direct assay evidence used in manual assertion

In figure 6, the authors demonstrate that porcine relaxin increases the proportion of cells that are positive for proliferating cell nuclear antigen, indicating cell proliferation.

challenge
acceptableHUMAN:REL2JmicG, Team Mighty Morphin GO Annotators2011-09-24 22:51:24 CDTGO:0048552 regulation of metalloenzyme activity (P)PMID:16049981ECO:0000314 direct assay evidence used in manual assertion

In figure 6A, the authors demonstrate that the addition of human relaxin increases the activity of matrix metalloproteinase activity in human prostate tumor cells.

challenge
acceptableHUMAN:REL2JmicG, Team Mighty Morphin GO Annotators2011-09-24 22:46:44 CDTGO:0045766 positive regulation of angiogenesis (P)PMID:16049981ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 8, the authors demonstrate that tumors, comprised of human prostate tumor cells, had greater microvessel density when made to overexpress human relaxin.

challenge
acceptableRAT:REL1JmicG, Team Mighty Morphin GO Annotators2011-09-24 22:26:01 CDTGO:0042127 regulation of cell proliferation (P)PMID:15498891ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 4, the authors demonstrate that the neutralization of endogenous relaxin during late pregnancy has a negative effect on cervical epithelial and stromal cell proliferation.

challenge
acceptableRAT:REL1JmicG, Team Mighty Morphin GO Annotators2011-09-24 22:25:18 CDTGO:0043066 negative regulation of apoptotic process (P)PMID:15498891ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 6, the authors demonstrate that the neutralization of endogenous relaxin during late pregnancy increases apoptosis in cervical epithelial and stromal tissue.

challenge
acceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-24 21:39:08 CDTGO:0001832 blastocyst growth (P)PMID:21272344ECO:0000314 direct assay evidence used in manual assertion

In table 4, the authors demonstrate that the addition of porcine relaxin during in vitro culture increases the number of cells in porcine blastocysts.

challenge
acceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-23 14:04:32 CDTGO:2000344 positive regulation of acrosome reaction (P)PMID:16926527ECO:0000314 direct assay evidence used in manual assertion

In figure 1, the authors demonstrate that the addition of porcine relaxin increased the proportion of live boar spermatozoa that had undergone the acrosome reaction.

challenge
unacceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-23 13:57:54 CDTGO:0034105 positive regulation of tissue remodeling (P)PMID:8319559ECO:0000314 direct assay evidence used in manual assertion

In figure 2, the authors show that porcine relaxin therapy in ovariectomized gilts restored collagen organization in the cervix during pregnancy.

challenge
acceptableHUMAN:REL2JmicG, Team Mighty Morphin GO Annotators2011-09-22 11:03:07 CDTGO:0010628 positive regulation of gene expression (P)PMID:11459784ECO:0000314 direct assay evidence used in manual assertion

In figure 1, the authors demonstrate that the addition of human relaxin stimulates the expression of pro-MMP-1 at both the mRNA and protein level.

challenge
acceptableCEREL:Q7YRI2SBowers, Team Mighty Morphin GO Annotators2011-09-21 22:43:32 CDTGO:0090290 positive regulation of osteoclast proliferation (P)PMID:11874237ECO:0000314 direct assay evidence used in manual assertion

The authors showed that treatment with PTHrP increased osteoclast proliferation. Figure 1.

challenge
acceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-21 16:47:52 CDTGO:0046326 positive regulation of glucose import (P)PMID:16926527ECO:0000314 direct assay evidence used in manual assertion

In figure 2, the authors demonstrate that the addition of porcine relaxin increases the glucose import in boar spermatozoa.

challenge
requireschangesHUMAN:RXFP1JmicG, Team Mighty Morphin GO Annotators2011-09-20 20:36:17 CDTGO:0030819 positive regulation of cAMP biosynthetic process (P)PMID:16569707ECO:0000314 direct assay evidence used in manual assertion

In figure 1, the authors demonstrate that human RXFP1 has a positive influence on cAMP production in the presence of its ligand.

challenge
acceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-20 18:33:12 CDTGO:0030317 sperm motility (P)PMID:16926527ECO:0000314 direct assay evidence used in manual assertion

In figure 1, the authors demonstrate that the addition of porcine relaxin increases the motility of boar spermatozoa.

challenge
acceptablePIG:RELXJmicG, Team Mighty Morphin GO Annotators2011-09-19 20:15:57 CDTGO:0001556 oocyte maturation (P)PMID:21272344ECO:0000314 direct assay evidence used in manual assertion

In table 2, the authors demonstrate that the addition of porcine relaxin during in vitro maturation reduced the the proportion of porcine oocytes that retained a germinal vesicle and increased the proportions of porcine oocytes that reach metaphase 2 (MII), both of which are characteristic of oocyte maturation.

challenge
acceptablePIG:F1RSS8JmicG, Team Mighty Morphin GO Annotators2011-09-19 19:51:44 CDTGO:0005886 plasma membrane (C)PMID:21251292ECO:0000314 direct assay evidence used in manual assertion

In figure 7, the authors demonstrate the presence of porcine RXFP2 on the plasma membrane of porcine oocytes and embryos using immunofluoresence.

challenge

Pages in category "Team Mighty Morphin GO Annotators"

The following 2 pages are in this category, out of 2 total.


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