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RAT:REL1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Rln1 (synonyms: Rln) | |
| Protein Name(s) | Prorelaxin 1
Relaxin B chain Relaxin A chain | |
| External Links | ||
| UniProt | P01347 | |
| EMBL | J00780 V01264 AY240029 | |
| PIR | A01614 | |
| RefSeq | NP_038199.1 | |
| UniGene | Rn.9830 | |
| Ensembl | ENSRNOT00000021315 | |
| GeneID | 25616 | |
| KEGG | rno:25616 | |
| UCSC | RGD:3579 | |
| CTD | 6013 | |
| RGD | 3579 | |
| eggNOG | NOG40989 | |
| GeneTree | ENSGT00510000048834 | |
| HOGENOM | HOG000236342 | |
| HOVERGEN | HBG003234 | |
| InParanoid | P01347 | |
| KO | K05255 | |
| OMA | LSEKCCQ | |
| OrthoDB | EOG7QZGC5 | |
| PhylomeDB | P01347 | |
| TreeFam | TF333404 | |
| Reactome | REACT_196378 REACT_246814 | |
| NextBio | 607371 | |
| PRO | PR:P01347 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | P01347 | |
| Genevestigator | P01347 | |
| GO | GO:0005576 GO:0005179 GO:0007188 GO:0060736 GO:0050878 GO:0010749 | |
| InterPro | IPR016179 IPR022353 IPR022421 | |
| Pfam | PF00049 | |
| PRINTS | PR02004 | |
| SMART | SM00078 | |
| SUPFAM | SSF56994 | |
| PROSITE | PS00262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042127 |
regulation of cell proliferation |
ECO:0000315 |
P |
In figure 4, the authors demonstrate that the neutralization of endogenous relaxin during late pregnancy has a negative effect on cervical epithelial and stromal cell proliferation. |
complete | |||||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
P |
In figure 6, the authors demonstrate that the neutralization of endogenous relaxin during late pregnancy increases apoptosis in cervical epithelial and stromal tissue. |
complete | |||||
|
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010749 |
regulation of nitric oxide mediated signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007188 |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050878 |
regulation of body fluid levels |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Lee, HY et al. (2005) The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Endocrinology 146 511-8 PubMed GONUTS page
- ↑ 2.0 2.1 Mookerjee, I et al. (2009) Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J. 23 1219-29 PubMed GONUTS page
- ↑ 3.0 3.1 Sunn, N et al. (2002) Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat. Proc. Natl. Acad. Sci. U.S.A. 99 1701-6 PubMed GONUTS page
