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MOUSE:INSL3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Insl3 (synonyms: Rlf) | |
| Protein Name(s) | Insulin-like 3
Leydig insulin-like peptide Ley-I-L Relaxin-like factor Insulin-like 3 B chain Insulin-like 3 A chain | |
| External Links | ||
| UniProt | O09107 | |
| EMBL | X95603 S82815 AF136524 | |
| CCDS | CCDS22404.1 | |
| UniGene | Mm.476857 | |
| ProteinModelPortal | O09107 | |
| SMR | O09107 | |
| PaxDb | O09107 | |
| PRIDE | O09107 | |
| MGI | MGI:108427 | |
| eggNOG | NOG80279 | |
| HOGENOM | HOG000113077 | |
| HOVERGEN | HBG052133 | |
| InParanoid | O09107 | |
| PhylomeDB | O09107 | |
| PRO | PR:O09107 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_INSL3 MM_RLF | |
| Genevestigator | O09107 | |
| GO | GO:0005576 GO:0001701 GO:0008584 | |
| Gene3D | 1.10.100.10 | |
| InterPro | IPR016179 IPR022353 IPR022352 | |
| Pfam | PF00049 | |
| PRINTS | PR00276 | |
| SMART | SM00078 | |
| SUPFAM | SSF56994 | |
| PROSITE | PS00262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000018 |
regulation of male gonad development |
ECO:0000315 |
P |
In figure 3 A&C, the authors demonstrate that homozygous mutant male mice, deficient in INSL3, exhibited bilateral cryptorchid testes located high in the abdomen. |
complete | |||||
|
involved_in |
GO:2000018 |
regulation of male gonad development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823966 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823966 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823966 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090303 |
positive regulation of wound healing |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043950 |
positive regulation of cAMP-mediated signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010634 |
positive regulation of epithelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008584 |
male gonad development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2661997 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008584 |
male gonad development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002020 |
protease binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001701 |
in utero embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2661997 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001556 |
oocyte maturation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620117 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zimmermann, S et al. (1999) Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13 681-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
e
n
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0010634 ! positive regulation of epithelial cell migration
- GO:0043950 ! positive regulation of cAMP-mediated signaling
- GO:0090303 ! positive regulation of wound healing
- GO:0002020 ! protease binding
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