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HUMAN:REL2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RLN2 | |
| Protein Name(s) | Prorelaxin H2
Relaxin B chain Relaxin A chain | |
| External Links | ||
| UniProt | P04090 | |
| EMBL | X00948 AL135786 BC126415 BC126419 S83200 AF104935 | |
| CCDS | CCDS6460.1 | |
| PIR | A05092 | |
| RefSeq | NP_005050.2 NP_604390.1 | |
| UniGene | Hs.127032 Hs.368996 | |
| PDB | 6RLX | |
| PDBsum | 6RLX | |
| ProteinModelPortal | P04090 | |
| SMR | P04090 | |
| STRING | 9606.ENSP00000371040 | |
| PhosphoSite | P04090 | |
| DMDM | 132281 | |
| PaxDb | P04090 | |
| PRIDE | P04090 | |
| DNASU | 6019 | |
| Ensembl | ENST00000381627 | |
| GeneID | 6019 | |
| KEGG | hsa:6019 | |
| UCSC | uc003ziz.2 uc003zja.2 | |
| CTD | 6019 | |
| GeneCards | GC09M005311 | |
| HGNC | HGNC:10027 | |
| MIM | 179740 | |
| neXtProt | NX_P04090 | |
| PharmGKB | PA34400 | |
| eggNOG | NOG40989 | |
| GeneTree | ENSGT00510000048834 | |
| HOGENOM | HOG000236342 | |
| HOVERGEN | HBG003234 | |
| InParanoid | P04090 | |
| KO | K05255 | |
| OMA | LSEKCCQ | |
| OrthoDB | EOG7QZGC5 | |
| PhylomeDB | P04090 | |
| TreeFam | TF333404 | |
| Reactome | REACT_19327 REACT_21314 | |
| EvolutionaryTrace | P04090 | |
| GenomeRNAi | 6019 | |
| NextBio | 23483 | |
| PRO | PR:P04090 | |
| Proteomes | UP000005640 | |
| Bgee | P04090 | |
| CleanEx | HS_RLN2 | |
| Genevestigator | P04090 | |
| GO | GO:0005576 GO:0007565 | |
| Gene3D | 1.10.100.10 | |
| InterPro | IPR016179 IPR022353 IPR022352 IPR022421 | |
| Pfam | PF00049 | |
| PRINTS | PR00276 PR02004 | |
| SMART | SM00078 | |
| SUPFAM | SSF56994 | |
| PROSITE | PS00262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
P |
In figure 1, the authors demonstrate that the addition of human relaxin stimulates the expression of pro-MMP-1 at both the mRNA and protein level. |
complete | |||||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045766 |
positive regulation of angiogenesis |
ECO:0000315 |
P |
In figure 8, the authors demonstrate that tumors, comprised of human prostate tumor cells, had greater microvessel density when made to overexpress human relaxin. |
complete | |||||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0048552 |
regulation of metalloenzyme activity |
ECO:0000314 |
P |
In figure 6A, the authors demonstrate that the addition of human relaxin increases the activity of matrix metalloproteinase activity in human prostate tumor cells. |
complete | |||||
|
involved_in |
GO:0050790 |
regulation of catalytic activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-744887 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Palejwala, S et al. (2001) Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology 142 3405-13 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Silvertown, JD et al. (2006) H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. Int. J. Cancer 118 62-73 PubMed GONUTS page
- ↑ Hudson, P et al. (1984) Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. EMBO J. 3 2333-9 PubMed GONUTS page
